Dehydroabietinol | CAS:3772-55-2 | Manufacturer ChemFaces

Dehydroabietinol

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Description:

Dehydroabietinol inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).

Targets:

Antifection

In vitro:

Planta Med. 2002 Jun;68(6):547-9.

Possible artefacts in the in vitro determination of antimalarial activity of natural products that incorporate into lipid bilayer: apparent antiplasmodial activity of dehydroabietinol, a constituent of Hyptis suaveolens.[Pubmed: 12094303]

METHODS AND RESULTS:
Dehydroabietinol isolated from Hyptis suaveolens (L.) Poit. was found to inhibit growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM). However, erythrocytes exposed to Dehydroabietinol were transformed in a dose-dependent manner towards spherostomatocytic forms with concomitant formation of endovesicles, as disclosed by transmission electron microscopy. The erythrocyte shape alterations caused by Dehydroabietinol correlated well with its apparent IC 50 value.
CONCLUSIONS:
Thus, Dehydroabietinol incorporates into the erythrocyte membrane, and since invasion and survival of Plasmodium parasites is known to depend on the function of the erythrocyte membrane, the observed antiplasmodial effect of Dehydroabietinol is presumably an indirect effect on the host cell. Because of these findings, microscopic investigations should be generally used to support claims of antimalarial effects of apolar natural products.

Dehydroabietinol Description

Source:	The barks of Pinus yunnanensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dehydroabietinol
Price:
CAS No.:	3772-55-2
Catalog No.:	CFN98609
Molecular Formula:	C₂₀H₃₀O
Molecular Weight:	286.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The barks of Pinus yunnanensis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antimalaric Compound Library Diterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4904 mL	17.452 mL	34.904 mL	69.808 mL	87.26 mL
5 mM	0.6981 mL	3.4904 mL	6.9808 mL	13.9616 mL	17.452 mL
10 mM	0.349 mL	1.7452 mL	3.4904 mL	6.9808 mL	8.726 mL
50 mM	0.0698 mL	0.349 mL	0.6981 mL	1.3962 mL	1.7452 mL
100 mM	0.0349 mL	0.1745 mL	0.349 mL	0.6981 mL	0.8726 mL

CFN98609	Dehydroabietinol	3772-55-2	286.5	C₂₀H₃₀O
CFN98438	7-Oxodehydroabietinol	33980-71-1	300.4	C₂₀H₂₈O₂
CFN97123	Daturabietatriene	65894-41-9	302.5	C₂₀H₃₀O₂
CFN99330	Abiesadine I	1210347-50-4	402.5	C₂₄H₃₄O₅
CFN98434	Abieta-8,11,13-triene-7,15,18-triol	337527-10-3	318.5	C₂₀H₃₀O₃
CFN98064	15,18-Dihydroxyabieta-8,11,13-trien-7-one	213329-45-4	316.4	C₂₀H₂₈O₃