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1. Reference standards
2. Pharmacological research
3. Inhibitors
Neochamaejasmine A
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $480.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Braz J Med Biol Res. 2016, 49(7)Nutrients.2021, 13(8):2901.Eur Endod J.2020, 5(1):23-27.Industrial Crops and Products...2022...Nutr Res Pract.2020, 14(5):478-489.Front Pharmacol.2021, 12:765521.Front Pharmacol.2021, 12:652860. Molecules.2020, 25(21):5091.
Mol Divers.2022, s11030-022-10586-3.Int J Mol Sci.2021, 22(14):7324.Int J Mol Sci.2022, 23(13):7115. The University of Manitoba2021, 35690.Nat Commun.2019, 10(1):5169Phytochemistry Letters2015, 243-247iScience.2020, 23(2):100849.Food Funct.2022, 13(13):6923-6933.
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Neochamaejasmine A
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Food and Chemical Toxicology2020, 111221Univerzita Karlova2022, 173245.Appl. Sci.2020, 10(5),1713.Nutrients.2021, 13(10):3414.Nutr Metab (Lond).2019, 16:31Front Pharmacol.2019, 10:1226PLoS One.2018, 13(3):e0193386Front Pharmacol.2022, 13:906763.Toxicol Res.2019, 35(4):371-387Front Immunol.2020, 11:598556.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery. |
| Targets: |
p21 | Caspase |
| In vitro: |
| J. Nat. Prod., 2008, 71(5):842-6. | | Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells.[Pubmed: 18380477 ] | Neochamaejasmine A ( 1), a biflavonoid isolated from the roots of a traditional Chinese medicine, Stellera chamaejasme L., was shown to inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells.
METHODS AND RESULTS:
Treatment of LNCaP cells with low doses of 1 (< or =6.25 microg/mL) suppressed DNA-binding activities of the transcription factors NFkappaB and AP-1 to the promoter of cyclin D and also inhibited expression of the cell cycle regulatory proteins cyclin D, proliferating cell nuclear antigen, and nucleolin, thus arresting cells in G 1 phase of the cell cycle. A lengthy exposure with higher doses of 1 (> or =12.5 microg/mL) revealed the production of reactive oxygen species, dissipation of the mitochondrial membrane potential, up-regulation of cyclin-dependent kinase inhibitor p21, and induction of cell apoptosis. An aggregation of Fas-procaspase 8-procaspase 3 and p21-procaspase 3 proteins by coimmunoprecipitation, immunoblotting analysis, and MALDI-mass spectrometry indicated the involvement of Fas and p21 in 1-mediated cytotoxicity, and pretreatment of cells with antisense FasL oligonucleotides partially abolished apoptosis.
CONCLUSIONS:
Thus, 1 blocked cell cycle progression at the G 1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery. |
|
Neochamaejasmine A Description
| Source: |
The roots of Stellera chamaejasme Linn. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.8433 mL |
9.2166 mL |
18.4332 mL |
36.8664 mL |
46.0829 mL |
| 5 mM |
0.3687 mL |
1.8433 mL |
3.6866 mL |
7.3733 mL |
9.2166 mL |
| 10 mM |
0.1843 mL |
0.9217 mL |
1.8433 mL |
3.6866 mL |
4.6083 mL |
| 50 mM |
0.0369 mL |
0.1843 mL |
0.3687 mL |
0.7373 mL |
0.9217 mL |
| 100 mM |
0.0184 mL |
0.0922 mL |
0.1843 mL |
0.3687 mL |
0.4608 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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