Info: More News
Science | Nature | Cell | View More
Natural Products
Neochamaejasmine A
Neochamaejasmine A
Information
CAS No. 90411-13-5 Price $418 / 5mg
Catalog No.CFN92151Purity>=98%
Molecular Weight542.5Type of CompoundFlavonoids
FormulaC30H22O10Physical DescriptionPowder
Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
Citing Use of our Products
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $480.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Kazusa DNA Research Institute (Japan)
  • Cornell University (USA)
  • Amity University (India)
  • University of Wisconsin-Madison (USA)
  • Universit?t Basel (Switzerland)
  • University of Cincinnati (USA)
  • University of Zurich (Switzerland)
  • Indian Institute of Science (India)
  • Donald Danforth Plant Science C... (USA)
  • Shanghai Institute of Biochemis... (China)
  • More...
  • Package
    Featured Products
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $338/20mg
    Angustifoline

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Mulberrofuran H

    Catalog No: CFN92414
    CAS No: 89199-99-5
    Price: $533/5mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $/mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Linderane

    Catalog No: CFN98175
    CAS No: 13476-25-0
    Price: $70/20mg
    Norwogonin

    Catalog No: CFN92218
    CAS No: 4443-09-8
    Price: $318/20mg

    Neochamaejasmine A

    Neochamaejasmine A
    Product Name Neochamaejasmine A
    CAS No.: 90411-13-5
    Catalog No.: CFN92151
    Molecular Formula: C30H22O10
    Molecular Weight: 542.5 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: p21 | Caspase
    Source: The roots of Stellera chamaejasme Linn.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $418 / 5mg
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
    product package
  • Food and Chemical Toxicology2020, 111221
  • Univerzita Karlova2022, 173245.
  • Appl. Sci.2020, 10(5),1713.
  • Nutrients.2021, 13(10):3414.
  • Nutr Metab (Lond).2019, 16:31
  • Front Pharmacol.2019, 10:1226
  • PLoS One.2018, 13(3):e0193386
  • Front Pharmacol.2022, 13:906763.
  • Toxicol Res.2019, 35(4):371-387
  • Front Immunol.2020, 11:598556.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
    Biological Activity
    Description: Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery.
    Targets: p21 | Caspase
    In vitro:
    J. Nat. Prod., 2008, 71(5):842-6.
    Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells.[Pubmed: 18380477 ]
    Neochamaejasmine A ( 1), a biflavonoid isolated from the roots of a traditional Chinese medicine, Stellera chamaejasme L., was shown to inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells.
    METHODS AND RESULTS:
    Treatment of LNCaP cells with low doses of 1 (< or =6.25 microg/mL) suppressed DNA-binding activities of the transcription factors NFkappaB and AP-1 to the promoter of cyclin D and also inhibited expression of the cell cycle regulatory proteins cyclin D, proliferating cell nuclear antigen, and nucleolin, thus arresting cells in G 1 phase of the cell cycle. A lengthy exposure with higher doses of 1 (> or =12.5 microg/mL) revealed the production of reactive oxygen species, dissipation of the mitochondrial membrane potential, up-regulation of cyclin-dependent kinase inhibitor p21, and induction of cell apoptosis. An aggregation of Fas-procaspase 8-procaspase 3 and p21-procaspase 3 proteins by coimmunoprecipitation, immunoblotting analysis, and MALDI-mass spectrometry indicated the involvement of Fas and p21 in 1-mediated cytotoxicity, and pretreatment of cells with antisense FasL oligonucleotides partially abolished apoptosis.
    CONCLUSIONS:
    Thus, 1 blocked cell cycle progression at the G 1 phase by activating the p21 protein and ultimately promoting the Fas-caspase 8-caspase 3 apoptotic machinery.
    Neochamaejasmine A Description
    Source: The roots of Stellera chamaejasme Linn.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Caohuoside E

    Catalog No: CFN95016
    CAS No: 174286-23-8
    Price: $318/5mg
    Batatasin V

    Catalog No: CFN95320
    CAS No: 65817-45-0
    Price: $318/5mg
    Apigenin 7-O-(6''-O-malonylglucosi...

    Catalog No: CFN95163
    CAS No: 86546-87-4
    Price: $318/5mg
    Peucenidin

    Catalog No: CFN95272
    CAS No: 33044-93-8
    Price: $318/5mg
    Grosvenorin 2''-glucoside

    Catalog No: CFN95282
    CAS No: N/A
    Price: $318/5mg
    4,4-di(4-hydroxy-3-methoxyphenly)-...

    Catalog No: CFN95200
    CAS No: 913643-31-9
    Price: $368/5mg
    2-Phenylethyl-beta-glucopyranoside

    Catalog No: CFN95429
    CAS No: 18997-54-1
    Price: $318/10mg
    N-trans-p-Coumaroyltyrosine

    Catalog No: CFN95279
    CAS No: 77201-66-2
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8433 mL 9.2166 mL 18.4332 mL 36.8664 mL 46.0829 mL
    5 mM 0.3687 mL 1.8433 mL 3.6866 mL 7.3733 mL 9.2166 mL
    10 mM 0.1843 mL 0.9217 mL 1.8433 mL 3.6866 mL 4.6083 mL
    50 mM 0.0369 mL 0.1843 mL 0.3687 mL 0.7373 mL 0.9217 mL
    100 mM 0.0184 mL 0.0922 mL 0.1843 mL 0.3687 mL 0.4608 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Isoliquiritin apioside

    Catalog No: CFN90800
    CAS No: 120926-46-7
    Price: $338/20mg
    Angustifoline

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Mulberrofuran H

    Catalog No: CFN92414
    CAS No: 89199-99-5
    Price: $533/5mg
    3-O-Feruloylquinic acid

    Catalog No: CFN92393
    CAS No: 1899-29-2
    Price: $/mg
    Chrysin 6-C-glucoside 8-C-arabinos...

    Catalog No: CFN92285
    CAS No: 185145-34-0
    Price: $368/5mg
    Linderane

    Catalog No: CFN98175
    CAS No: 13476-25-0
    Price: $70/20mg
    Norwogonin

    Catalog No: CFN92218
    CAS No: 4443-09-8
    Price: $318/20mg
    Tags: buy Neochamaejasmine A | Neochamaejasmine A supplier | purchase Neochamaejasmine A | Neochamaejasmine A cost | Neochamaejasmine A manufacturer | order Neochamaejasmine A | Neochamaejasmine A distributor