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    Natural Products
    Dihydrowithaferin A
    Dihydrowithaferin A
    Information
    CAS No. 5589-41-3 Price $268 / 5mg
    Catalog No.CFN91055Purity>=98%
    Molecular Weight472.6Type of CompoundSteroids
    FormulaC28H40O6Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $268 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Dihydrowithaferin A

    Dihydrowithaferin A
    Product Name Dihydrowithaferin A
    CAS No.: 5589-41-3
    Catalog No.: CFN91055
    Molecular Formula: C28H40O6
    Molecular Weight: 472.6 g/mol
    Purity: >=98%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Source: The herbs of Physali alkekengi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $268 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Steroids Compound Library
  • Biological Activity
    Description: 2, 3-Dihydrowithaferin A in the diet may prevent or decrease the growth of tumors in human.
    In vitro:
    Life Sci. 2003 Nov 21;74(1):125-32.
    Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.[Pubmed: 14575818]
    Ayurvedic medicines prepared in India consist of Withania somnifera roots as one of the main ingredients. It is consumed as a dietary supplement around the world. The leaves of W. somnifera were used in the treatment of tumors and inflammation in several Asian countries.
    METHODS AND RESULTS:
    We have isolated twelve withanolides such as withaferin A (1), sitoindoside IX (2), 4-(1-hydroxy-2, 2-dimethylcyclpropanone)-2, 3-Dihydrowithaferin A (3), 2, 3-Dihydrowithaferin A (4), 24, 25-dihydro-27-desoxywithaferin A (5), physagulin D (1-->6)-beta-D-glucopyranosyl- (1-->4)-beta-D-glucopyranoside (6), 27-O-beta-D-glucopyranosylphysagulin D (7), physagulin D (8), withanoside IV (9), and 27-O-beta-D-glucopyranosylviscosalactone B (10), 4, 16-dihydroxy-5beta, 6beta-epoxyphysagulin D (11), viscosalactone B (12) from the leaves of this species. Compounds 1-12 and diacetylwithaferin A (13) were tested for their antiproliferative activity on NCI-H460 (Lung), HCT-116 (Colon), SF-268 (Central Nervous System; CNS and MCF-7 (Breast) human tumor cell lines. The inhibitory concentration to afford 50% cell viability (IC50) for these compounds was determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay. Withaferin A and its derivatives exhibited inhibitory concentrations (50%) ranging from 0.24 +/- 0.01 to 11.6 +/- 1.9 microg/mL. Viscosalactone B (12) showed the 50% inhibition at concentrations ranging from 0.32 +/- 0.05 to 0.47 +/- 0.15 microg/mL whereas its 27-O-glucoside derivative (10) exhibited IC50 between 7.9 +/- 2.9 and 17.3 +/- 3.9 microg/ml. However, Physagulin D type withanolides showed either weak or no activity at 30 microg/mL.
    CONCLUSIONS:
    Therefore, incorporation of withanolides in the diet may prevent or decrease the growth of tumors in human.
    Dihydrowithaferin A Description
    Source: The herbs of Physali alkekengi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.116 mL 10.5798 mL 21.1595 mL 42.3191 mL 52.8989 mL
    5 mM 0.4232 mL 2.116 mL 4.2319 mL 8.4638 mL 10.5798 mL
    10 mM 0.2116 mL 1.058 mL 2.116 mL 4.2319 mL 5.2899 mL
    50 mM 0.0423 mL 0.2116 mL 0.4232 mL 0.8464 mL 1.058 mL
    100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.4232 mL 0.529 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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