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    Natural Products
    Durantoside I
    Durantoside I
    Information
    CAS No. 53526-67-3 Price
    Catalog No.CFN97726Purity>=98%
    Molecular Weight552.53Type of CompoundIridoids
    FormulaC26H32O13Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Durantoside I

    Durantoside I
    Product Name Durantoside I
    CAS No.: 53526-67-3
    Catalog No.: CFN97726
    Molecular Formula: C26H32O13
    Molecular Weight: 552.53 g/mol
    Purity: >=98%
    Type of Compound: Iridoids
    Physical Desc.: Powder
    Source: The herbs of Duranta repens
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
    Inquire / Order: manager@chemfaces.com
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  • Int J Mol Med.2016, 37(2):501-8
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
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  • Biological Activity
    Description: Durantoside I has inhibitory activity on the growth of lettuce seedling. It also displays DPPH scavenging activity.
    In vitro:
    Industrial Crops & Products,2015, 76(1):653-9.
    Phytochemical and phytotoxic investigation of the flowers from Citharexylum spinosum L.[Reference: WebLink]
    The aim of this study was to assess the phytotoxic potential of flowers of Citharexylum spinosum, as well as to isolate the main bioactive compounds.
    METHODS AND RESULTS:
    Results showed that the ethyl acetate extract induced the highest reduction, showing 100% inhibition of lettuce growth at 6000 ppm. This bioactive ethyl acetate extract was subjected to bio-guided chromatographic separation yielding the acetylated form of a new iridoid glucoside, designated as spinoside (1) together with two acetylated forms (2a) and (2b) of its known analogue Durantoside I (2).
    CONCLUSIONS:
    Their structures were established via their acetylated derivatives by means of spectroscopic and chemical data. The most inhibitory compound on the growth of lettuce seedling was identified to be the durantoside-I tetraacetylated (2b).
    J. Pharm. Res.,2013,7(2):162-6.
    New protein glycation inhibitory free radical scavenging compound from Duranta repens L.[Reference: WebLink]
    Hyperglycemia induced oxidative stress, increased generation of free radicals and free radicals mediated glycation of protein molecules are important events aggravating development of a number of diabetic complications. To identify antiglycation principles with free radicals scavenging activities from traditional oriental medicinal plants.
    METHODS AND RESULTS:
    Biological activity ABTS+ radical scavenging in particular, guided isolation of active compounds was performed from methanolic extract of traditional oriental medicinal plants Duranta repense. Isolated compounds were further studied for their DPPH radical scavenging activity and advanced glycation end-products inhibitory potentials in vitro. Activity guided isolation from methanolic extract of D. repens led to the identification of five iridoids namely Caryoptoside (1), Duraterectoside A (2), Durantoside III (3), Durantoside I (4), Lamiide (7) and two lignans namely (+) 5′Methoxyisolariciresinol (5), (−)5′Methoxyisolariciresinol (6). All the compounds scavenged ABTS+ radical, Caryoptoside (1) and (+) 5′Methoxyisolariciresinol (5) being most potent ABTS+ scavenger (IC50 = 6.0 and 3.1 μg/mL respectively). Only (+) 5′Methoxyisolariciresinol (5) displayed DPPH scavenging activity (IC50 = 70.5 μg/mL). Despite being potent ABTS+ scavenges, iridoid compounds rather augmented glucose induced formation of advanced glycation end-products in bovine serum albumin protein. (+) 5′Methoxyisolariciresinol (5) displayed both, the potent ABTS+ and DPPH scavenging activity however, showed mild (10%) antiglycation activity. On the other hand, (−) isomer of lignin 5′Methoxyisolariciresinol (6) that displayed moderate ABTS+ scavenging activity (IC50 = 42.6 μg/mL) potently inhibited (45%) glucose induced glycation of bovine serum albumin (BSA) protein.
    CONCLUSIONS:
    Methanol extract of D. repense possess potent antioxidant compounds. Iridoids augmented glucose induced glycation of BSA. Lignans displayed antiglycation activity. The (−) isomer of lignan 5′Methoxyisolariciresinol (6) was five times more potent in inhibiting glucose induced generation of AGEs in BSA.
    Durantoside I Description
    Source: The herbs of Duranta repens
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.8099 mL 9.0493 mL 18.0986 mL 36.1971 mL 45.2464 mL
    5 mM 0.362 mL 1.8099 mL 3.6197 mL 7.2394 mL 9.0493 mL
    10 mM 0.181 mL 0.9049 mL 1.8099 mL 3.6197 mL 4.5246 mL
    50 mM 0.0362 mL 0.181 mL 0.362 mL 0.7239 mL 0.9049 mL
    100 mM 0.0181 mL 0.0905 mL 0.181 mL 0.362 mL 0.4525 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochemistry. 1995 Jul;39(4):829-33.
    Iridoid glucosides from the leaves and stems of Duranta erecta.[Pubmed: 7626266]

    METHODS AND RESULTS:
    From the leaves of Duranta erecta, four new iridoid glucosides, duranterectosides A, B, C and D, were isolated along with Durantoside I and Durantoside II, lamiide, lamiidoside and verbascoside. Duranterectoside A was also isolated from the stems together with Durantoside I, II and III, and lamiidoside. The structures of the new compounds were elucidated based on the spectroscopic evidence.
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