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    Natural Products
    Ecgonine
    Ecgonine
    Information
    CAS No. 481-37-8 Price
    Catalog No.CFN00189Purity>=98%
    Molecular Weight185.22Type of CompoundAlkaloids
    FormulaC9H15NO3Physical DescriptionOil
    Download     COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Ecgonine

    Ecgonine
    Product Name Ecgonine
    CAS No.: 481-37-8
    Catalog No.: CFN00189
    Molecular Formula: C9H15NO3
    Molecular Weight: 185.22 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Oil
    Source: The herbs of Erythroxylum coca
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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  • Int J Immunopathol Pharmacol.2019, 33:2058738419857537
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Markers Compound Library
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  • Biological Activity
    Description: Ecgonine is a promising marker of cocaine ingestion.
    In vivo:
    J Anal Toxicol. 2010 Mar;34(2):57-63.
    Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.[Pubmed: 20223096]

    METHODS AND RESULTS:
    Urinary excretion of Ecgonine (EC) was compared to that of cocaine, benzoylEcgonine, Ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylEcgonine, para-hydroxybenzoylEcgonine, and norbenzoylEcgonine, following controlled administration of oral, intravenous, intranasal, and smoked cocaine. Urine EC concentrations peaked later than all other analytes and had longer detection times than the other minor metabolites. With a 50 ng/mL cutoff concentration and following low doses of 10 to 45 mg cocaine by multiple routes, detection times extended up to 98 h. Maximum concentrations (Cmax) were 6-14 mole % of those for benzoylEcgonine, Cmax increased with dose, time to maximum concentration (Tmax) was independent of dose, and route of administration did not have a significant impact on Cmax or Tmax for metabolites.
    CONCLUSIONS:
    EC is an analyte to consider for identifying cocaine use due to its stability in urine and long detection times.
    Ecgonine Description
    Source: The herbs of Erythroxylum coca
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.399 mL 26.9949 mL 53.9898 mL 107.9797 mL 134.9746 mL
    5 mM 1.0798 mL 5.399 mL 10.798 mL 21.5959 mL 26.9949 mL
    10 mM 0.5399 mL 2.6995 mL 5.399 mL 10.798 mL 13.4975 mL
    50 mM 0.108 mL 0.5399 mL 1.0798 mL 2.1596 mL 2.6995 mL
    100 mM 0.054 mL 0.2699 mL 0.5399 mL 1.0798 mL 1.3497 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Anal Bioanal Chem. 2013 Dec;405(30):9805-16.
    Determination of ecgonine and seven other cocaine metabolites in human urine and whole blood by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry.[Pubmed: 24202193]
    Ecgonine is suggested to be a promising marker of cocaine (COC) ingestion.
    METHODS AND RESULTS:
    A combined mass spectrometry (MS) and tandem MS (MS/MS) method was developed to simultaneously determine Ecgonine and seven other metabolites of cocaine in human urine and whole blood with ultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. The compounds were extracted from as little as 100 ╬╝L of sample by solid-phase extraction with a 96-well ╬╝Elution solid-phase extraction plate. The protonated molecules or fragment ions at accurate mass acquired in MS mode were used to quantify specific analytes, following by dedicated MS/MS identification. The assay was linear in the range from 5 to 50-100 ng/mL for urine samples, except for Ecgonine methyl ester (10-200 ng/mL) and Ecgonine (40-400 ng/mL), and was linear from 1-2 to 50 ng/mL for whole blood samples, except for Ecgonine methyl ester (20-1,000 ng/mL) and Ecgonine (40-2,000 ng/mL).
    CONCLUSIONS:
    The validated method was successfully applied to the analysis of real samples derived from forensic cases, and the results verified that, on the basis of data from four positive samples, Ecgonine is a promising marker of cocaine ingestion.
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