ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Life (Basel).2021, 11(7):616. Phytomedicine.2019, 56:48-56Environ Toxicol.2021, 36(9):1848-1856.HIV Med.2021, 22(8):690-704.Toxins (Basel).2019, 11(10):E575Biomed Pharmacother.2022, 145:112410. Int J Biol Macromol.2020, 169:342-351Medicinal Chemistry Research ...2021...
Front Pharmacol.2021, 12:770667.Agronomy 2021, 11(3),502.LWT-Food Science and Technology...2017...Phytomedicine.2019, 59:152785Int J Mol Med.2015, 35(5):1237-45Neurotox Res.2020, 38(1):163-174.Appl. Sci. 2021, 11(8),3437.Metabolites.2020, 10(11):440.
Molecules.2019, 24(7):E1290Biochem Biophys Res Commun....2018...Nutrients.2021, 13(3):978. Food Research2021, 5(1):65-71J.Acta Agriculturae Scandinavica...2017...Food Res Int.2018, 106:909-919Evid Based Complement Alternat Me...2018...
Our products had been exported to the following research institutions and universities, And still growing.
Universidad de Buenos Aires (Argentina)Universidad Industrial de Santa... (Colombia)Instituto de Investigaciones Ag... (Chile)Monash University Sunway Campus (Malaysia)
Chinese University of Hong Kong (China)St. Jude Children Research Hosp... (USA)Sapienza University of Rome (Italy)Seoul National University (Korea)
CSIRO - Agriculture Flagship (Australia)University of the Basque Country (Spain)The Australian National University (Australia)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Internoational J of Toxicology2020, 10.1177.Journal of Food Hygiene and Safety2019, 34(5):413-420Anal Sci.2019, 35(12):1317-1325Tropical J. of Pha. Research2017, 16(3):543-552Chemistry of Vegetable Raw Materials2019, 3:119-127Natural Product Communications2020, doi: 10.1177.Eur J Neurosci.2021, 53(11):3548-3560.Biochemical Systematics and Ecology2018, 81Korean Herb. Med. Inf. 2016, 4(1):35-42J Korean Society of Food Science & Nutrition2021, 50(9): 962-970
Related Screening Libraries
||Ecgonine is a promising marker of cocaine ingestion.|
|J Anal Toxicol. 2010 Mar;34(2):57-63. |
|Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.[Pubmed: 20223096]|
METHODS AND RESULTS:
Urinary excretion of Ecgonine (EC) was compared to that of cocaine, benzoylEcgonine, Ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylEcgonine, para-hydroxybenzoylEcgonine, and norbenzoylEcgonine, following controlled administration of oral, intravenous, intranasal, and smoked cocaine. Urine EC concentrations peaked later than all other analytes and had longer detection times than the other minor metabolites. With a 50 ng/mL cutoff concentration and following low doses of 10 to 45 mg cocaine by multiple routes, detection times extended up to 98 h.
Maximum concentrations (Cmax) were 6-14 mole % of those for benzoylEcgonine, Cmax increased with dose, time to maximum concentration (Tmax) was independent of dose, and route of administration did not have a significant impact on Cmax or Tmax for metabolites.
EC is an analyte to consider for identifying cocaine use due to its stability in urine and long detection times.
||The herbs of Erythroxylum coca
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Anal Bioanal Chem. 2013 Dec;405(30):9805-16. |
|Determination of ecgonine and seven other cocaine metabolites in human urine and whole blood by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry.[Pubmed: 24202193]|
|Ecgonine is suggested to be a promising marker of cocaine (COC) ingestion.
METHODS AND RESULTS:
A combined mass spectrometry (MS) and tandem MS (MS/MS) method was developed to simultaneously determine Ecgonine and seven other metabolites of cocaine in human urine and whole blood with ultra-high-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. The compounds were extracted from as little as 100 μL of sample by solid-phase extraction with a 96-well μElution solid-phase extraction plate. The protonated molecules or fragment ions at accurate mass acquired in MS mode were used to quantify specific analytes, following by dedicated MS/MS identification. The assay was linear in the range from 5 to 50-100 ng/mL for urine samples, except for Ecgonine methyl ester (10-200 ng/mL) and Ecgonine (40-400 ng/mL), and was linear from 1-2 to 50 ng/mL for whole blood samples, except for Ecgonine methyl ester (20-1,000 ng/mL) and Ecgonine (40-2,000 ng/mL).
The validated method was successfully applied to the analysis of real samples derived from forensic cases, and the results verified that, on the basis of data from four positive samples, Ecgonine is a promising marker of cocaine ingestion.