|Natural Product Research and Development, 2010. |
|Sesquiterpenoids from Tibetan Folk Drug Pulicaria insignis.[Reference: WebLink]|
METHODS AND RESULTS:
Eleven known sesquiterpenoids were isolated from the Tibetan Folk Drug Pulicaria insignis.On the basis of MS and NMR data,they were identified as Xanthanolide(1),(3αR,4αR,5R,7αS,9αS)-5-Hydroxy -5-methyl-3,8-dimethylenedecahydroazulenofuran-2(3H)-one(2),10α-hydroxy-14H-inuviscolide(3),(3R,3αR,4αS,7αS,8S,9αS)-3,4α,8-Trimethyldecahydroazulenofuran-2,5-dione(4),8-Epi-conferti(5),(3αR,5S,11αS,E)-5-Hydroxy-10-methyl-3,6-dimethylene-3α,4,5,6,7,8,11,11α,-octahydrocyclodeca[α] furan-2(3H)-one(6),(3αR,8αR,9αR)-5,8α-Dimethyl-3-methylene-3α,4,8,8α,9,9α-hexahydronaphtho furan-2,6(3H,7H)-dione(7),Pterodonoic acid(8),8-Epi-isovangustin(9),(3αR,4αS,8R,8αR,9αR)-8 -Hydroxy-5,8α-dimethyl-3-methylene-3,3α,4,4α,8,8α,9,9α-octahydronaphthofuran-2(7H)-one(10) (5S,8αR,9αR)-3-(Hydroxymethyl)-5,8α-dimethyl-6,7,8,8α,9,9α-hexahydronaphthofuran-2(5H) one(11).
All compounds were isolated from this plant for the first time,and the 13C NMR data of compounds 6 and 9 were shawed in this paper.