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    Natural Products
    Eleutheroside D
    Information
    CAS No. 79484-75-6 Price $368 / 10mg
    Catalog No.CFN98510Purity>=98%
    Molecular Weight742.72Type of CompoundLignans
    FormulaC34H46O18Physical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $316.5 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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  • Package
    Featured Products
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    Eleutheroside D

    Eleutheroside D
    Product Name Eleutheroside D
    CAS No.: 79484-75-6
    Catalog No.: CFN98510
    Molecular Formula: C34H46O18
    Molecular Weight: 742.72 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Source: The root barks of Eleutherococcus senticosus
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $368 / 10mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • J of L. Chroma.&Related Tech2017, 252-258
  • PLoS One.2017, 12(3):e0173585
  • Front Pharmacol.2021, 12:607403.
  • Nutrients.2021, 13(12):4364.
  • Molecules.2019, 24(10):E1930
  • Int J Mol Sci.2018, 19(9):E2681
  • Food Chem.2022, 378:131975.
  • Inflammation.2021, doi: 10.1007
  • Research Square2021, March 3rd.
  • Phytomedicine.2019, 57:95-104
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cardioprotective Compound Library
  • Lignans Compound Library
  • Biological Activity
    Description: Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
    In vivo:
    Chinese General Practice, 2009, 12(4):292-4.
    Protective Effect of Eleutheroside Preconditioning to Myocardial Ischemic Reperfusion Injury in Isolated Rats[Reference: WebLink]
    To investigate the protective effect of eleutherosid preconditioning to myocardial ischemic-reperfusion injury(IRI) in isolated rats and the dose-effect relationship between eleutheroside preconditioning and the myocardial protection.
    METHODS AND RESULTS:
    Male rat hearts,which were isolated and perfused with Langendorff apparatus,were randomly divided into 5 groups,6 in each.The isolated hearts were subjected to 25 min ischemia and then followed by 30 min reperfusion after 15min stabilization in control group(C).In the eleutheroside preconditioned groups(P1,P2,P3,P4),the hearts were perfused with eleutheroside(30 mg/kg,40 mg/kg,60 mg/kg and 80mg/kg,respectively) for 10 min before ischemia-reperfusion.Left ventricular developed pressure(LVDP),left ventricular end diastolic pressure(LVEDP),maximal rate of increase /decrease of left ventricular pressure(±dp/d tMax),and coronary blood flow(CF) were monitored continuously.And an arrhythmias score was used to quantify the arrhythmias during reperfusion.After reperfusing 30 min reperfusion,as compared with group C,① P2 and P3 groups might increase LVDP、+dp/dtMax and-dp/dtMax more significantly(P0.05);②P2 and P3 groups might raise CF more significantly(P0.01);③P2 and P3 groups had lower arrhythmia scores(P0.05).
    CONCLUSIONS:
    Eleutheroside preconditioning has a dose-effect on IRI of isolated rat hearts.
    Evid Based Complement Alternat Med . 2013;2013:934183.
    Eleutheroside E, An Active Component of Eleutherococcus senticosus, Ameliorates Insulin Resistance in Type 2 Diabetic db/db Mice[Pubmed: 23690865]
    Abstract Eleutheroside E (EE), a principal component of Eleutherococcus senticosus (ES), has anti-inflammatory and protective effects in ischemia heart. However, it is unknown whether it ameliorates insulin resistance and reduces hyperglycemia in diabetes. This study investigated the effect of EE-containing ES extracts, as well as EE, on hyperglycemia and insulin resistance in db/db mice. EE increased the insulin-provoked glucose uptake in C2C12 myotubes. Moreover, EE improved TNF- α -induced suppression of glucose uptake in 3T3-L1 adipocytes. Five-week-old db/db mice were fed a diet consisting of ES extract or EE for 5 weeks. Both were effective in improving serum lipid profiles and significantly decreased blood glucose and serum insulin levels. ES and EE supplementation effectively attenuated HOMA-IR. Glucose tolerance and insulin tolerance tests showed that EE increased insulin sensitivity. Immunohistochemical staining indicated that ES and EE protected pancreatic alpha and beta cells from diabetic damage. In addition, ES and EE improved hepatic glucose metabolism by upregulating glycolysis and downregulating gluconeogenesis in obese type 2 diabetic mice. These data suggest that EE mediates the hyperglycemic effects of ES by regulating insulin signaling and glucose utilization. The beneficial effects of EE may provide an effective and powerful strategy to alleviate diabetes.
    Eleutheroside D Description
    Source: The root barks of Eleutherococcus senticosus
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3464 mL 6.732 mL 13.464 mL 26.928 mL 33.6601 mL
    5 mM 0.2693 mL 1.3464 mL 2.6928 mL 5.3856 mL 6.732 mL
    10 mM 0.1346 mL 0.6732 mL 1.3464 mL 2.6928 mL 3.366 mL
    50 mM 0.0269 mL 0.1346 mL 0.2693 mL 0.5386 mL 0.6732 mL
    100 mM 0.0135 mL 0.0673 mL 0.1346 mL 0.2693 mL 0.3366 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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