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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $16.9 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Exp Parasitol.2015, 153:160-4The Journal of Internal Korean Me...2015...Inflammation.2015, 38(4):1502-16Evid Based Complement Alternat Me...2016...J. of The Korean Society of Food ...2017...Aquaculture2017, 481:94-102Nutrients.2018, 10(7)Nat Chem Biol.2018, 14(8):760-763
Molecules.2018, 23(10):E2638Sci Rep.2018, 8(1)Sci Rep.2018, 8:15059Nutrients.2019, 11(11):E2694Mol Microbiol.2019, 112(1):317-332Nat Prod Sci.2019, 25(3):238Psychopharmacology (Berl).2020, 10.1007Drug Chem Toxicol.2020, 1-14.
Nutrients.2020, 12(11):3448. LWT2020, 130:109535BioResources J.2020, 15(3).Evid Based Complement Alternat Me...2020...Evid Based Complement Alternat Me...2020...Int J Mol Sci.2020, 21(9):3392. Drug Dev Res.2020, doi: 10.1002
Our products had been exported to the following research institutions and universities, And still growing.
Institute of Tropical Disease U... (Indonesia)University of Otago (New Zealand)The University of Newcastle (Australia)Institute of Pathophysiology Me... (Austria)
Universidad Miguel Hernández (Spain)Periyar University (India)Medizinische Universit?t Wien (Austria)FORTH-IMBB (Greece)
National Cancer Institute (USA)Agricultural Research Organizat... (Israel)Universidad Veracuzana (Mexico)
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University of Central Lancashire2017, 20472Int J Mol Sci.2019, 21(1):E265BioResources J.2020, 15(3).J Sep Sci.2018, 41(7):1682-1690Plant Cell, Tissue and Organ Culture (PCTOC)2020, 143, 45-60(2020)Pharmaceutics.2020, 12(9):845.J of Dentistry & Oral Health2019, 2641-1962Front Plant Sci.2020, 10:1705PLoS One.2018, 13(3):e0193386Plants (Basel).2020, 9(11):1422.
Related Screening Libraries
||Daidzin is a potent, selective aldehyde dehydrogenase 2 (ALDH2,IC50 = 80 nM) inhibitor, which has antiallergic anti-oxidant, anti-carcinogenic, antithrombotic,and anti-atherosclerotic activities, It has preventive effect on bone loss in ovariectomized rats appears to be due to suppression of bone turnover. A mixture of daidzin and glycitin has anti-obese and anti-diabetic effects.|
||IL Receptor | ALDH2|
|Biosci Biotechnol Biochem. 2015 Jan;79(1):117-23. |
|Anti-obese and anti-diabetic effects of a mixture of daidzin and glycitin on C57BL/6J mice fed with a high-fat diet.[Pubmed: 25209298]|
METHODS AND RESULTS:
We investigated the effects of a mixture of Daidzin and glycitin, which are the glycoside-form isoflavones of daidzein and glycitein, respectively, on body weight, lipid levels, diabetic markers, and metabolism in a high-fat diet (HF) fed C57BL/6J mice for 92 days. The mice were divided into basic diet group (CON), HF group, and HF companied with the isoflavone mixture group (HFISO). Results showed that mice in HFISO had a significantly lower body weight and adipose tissue compared to HF group. Blood glucose, serum HbA1c, and serum insulin also showed lower levels in HFISO group. In addition, higher hepatic GSH level and lower serum 8-hydroxy-2'-deoxyguanosine (8-OHdG) level were found in HFISO group mice.
This suggests that the regulation of oxidative stress by Daidzin and glycitin was closely related to the suppression of adipose tissue and the progression of diabetes.
|J Hepatol. 2014 Dec 24. pii: S0168-8278(14)00943-X. |
|Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.[Pubmed: 25543082]|
|Effective therapies for alcoholic liver disease are currently unavailable. The present study tested the efficacy of Alda-1, a specific aldehyde dehydrogenase 2 (ALDH2) activator, in treating alcoholic liver disease.
METHODS AND RESULTS:
Male C57BL/6J mice were exposed to alcohol for a time-course study on aldehyde metabolism. The specificity and efficacy of Alda-1 on activating hepatic ALDH2 and aldehyde clearance were determined by acute treatments. Then, mice were fed alcohol for 8 weeks with Alda-1 administration for the last 10 days to test the therapeutic potential of Alda-1. Lastly, H4IIEC3 cells were treated with ethanol, acetaldehyde, or 4-hydroxynonenal to define the link between aldehydes and hepatotoxicity.
Alcohol feeding for 8 weeks induced hepatic ALDH2 dysfunction and aldehyde accumulation. One dose of Alda-1 administration elevated hepatic ALDH activity, which was blocked by the specific ALDH2 inhibitor, Daidzin. Alda-1 accelerated acetaldehyde clearance after acute alcohol intoxication. Alda-1 treatment in the 8-week alcohol feeding model reversed liver damage along with reduction of hepatic aldehydes. Alda-1 re-activated transcription factors, upregulated fatty acid oxidation enzymes, and reversed steatosis. Alcohol-induced endoplasmic reticulum stress and apoptotic cell death were also attenuated by Alda-1. Acetaldehyde or 4-hydroxynonenal treatment to H4IIEC3 cells inactivated transcription factors and induced endoplasmic reticulum stress and apoptosis, while ethanol per se showed limited effects.
Pharmacological activation of ALDH2 by Alda-1 reversed alcoholic steatosis and apoptosis through accelerating aldehyde clearance. This study indicates that ALDH2 is a promising molecular target and Alda-1 has therapeutic potential for treating alcoholic liver disease.
|Biol Pharm Bull. 2002 Oct;25(10):1328-32. |
|Antithrombotic and antiallergic activities of daidzein, a metabolite of puerarin and daidzin produced by human intestinal microflora.[Pubmed: 12392089]|
|To evaluate the antithrombotic activities of puerarin and Daidzin from the rhizome of Pueraria lobata, in vitro and ex vivo inhibitory activities of these compounds and their metabolite, daidzein, were measured. These compounds inhibited ADP- and collagen-induced platelet aggregation. Daidzein was the most potent. However, when puerarin and Daidzin were intraperitoneally administered, their antiaggregation activities were weaker than when these compounds were administered orally.
When in vivo antithrombotic activities of these compounds against collagen and epinephrine were measured, these compounds showed significant protection from death due to pulmonary thrombosis in mice.
METHODS AND RESULTS:
To evaluate the antiallergic activity of puerarin, Daidzin, and daidzein, their inhibitory effects on the release of beta-hexosaminidase from RBL 2H3 cells and on the passive cutaneous anaphylaxis (PCA) reaction in mice were examined. Daidzein exhibited potent inhibitory activity on the beta-hexosaminidase release induced by DNP-BSA and potently inhibited the PCA reaction in rats. Daidzein administered intraperitoneally showed the strongest inhibitory activity and significantly inhibited the PCA reaction at doses of 25 and 50mg/kg with inhibitory activity of 37 and 73%, respectively. The inhibitory activity of intraperitoneally administered daidzein was stronger than those of intraperitoneally and orally administered puerarin and Daidzin.
Therefore we believe that puerarin and Daidzin in the rhizome of Pueraria lobata are prodrugs, which have antiallergic and antithrombotic activities, produced by intestinal microflora.
||The roots of Pueraria lobata.
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Mol Cell Endocrinol. 2013 Aug 25;376(1-2):107-13. |
|Identification of daidzein as a ligand of retinoic acid receptor that suppresses expression of matrix metalloproteinase-9 in HaCaT cells.[Pubmed: 23791815 ]|
|Cell lines:CV-1 cells|
Concentrations: 0.5, 1, 10, 50, and 100 μM
Incubation Time: 24 h
CV-1 cells are transfected with 100 ng ERE-Luc and 50 ng ER-RARα or ER-RARγ. Transfected cells are treated with the indicated isoflavone at 0.5, 1, 10, 50, and 100 μM for 24 h. The β-Gal activity is used to normalize luciferase activity.
|Biol Pharm Bull. 1998 Jan;21(1):62-6. |
|Preventive effects of the plant isoflavones, daidzin and genistin, on bone loss in ovariectomized rats fed a calcium-deficient diet.[Pubmed: 9477170]|
|Animal Models: Ovx rats |
Formulation: 40% ethanol solution
Dosages:50 mg/kg/d for 4 weeks