ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
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4. Contact information
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $171.4 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Breast Cancer.2015, 18(2):112-118Korean Journal of Pharmacognosy....2015...Chem Biol Interact.2016, 260:168-175Phytochemistry Letters2017, 449-455Plant J.2017, 90(3):535-546BMC Plant Biol.2018, 18(1):122Korean Journal of Medicinal Crop ...2018...Front Pharmacol.2018, 9:756
Clin Transl Oncol.2019, 10.1007Journal of Ginseng Research...2019...Front Microbiol.2019, 10:2806Chem Biol Interact.2019, 315:108910Toxicol In Vitro.2019, 59:161-178Planta Med.2019, 85(3):217-224Appl. Sci.2020, 10(23), 8729Front Immunol. 2020, 11:62.
PLoS One.2020, 15(2):e0220084.Int J Mol Sci.2020, 21(9):3239.Eur Rev Med Pharmacol Sci....2020...J of l. Chroma.&Related Tech...2020...Korean Journal of Pharmacognosy....2020...J of Applied Biological Chem....2020...J Agric Food Chem....2020...
Our products had been exported to the following research institutions and universities, And still growing.
CSIRO - Agriculture Flagship (Australia)University of Limpopo (South Africa)Stanford University (USA)Melbourne University (Australia)
University of Padjajaran (Indonesia)University of Maryland (USA)National Hellenic Research Foun... (Greece)University of Mysore (India)
Yale University (USA)Mahidol University (Thailand)Institute of Tropical Disease U... (Indonesia)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Adaptive Medicine 2020, 12(1): 4-10Curr Eye Res.2018, 43(1):27-34Food Res Int.2017, 96:40-45Molecules.2018, 23(12):E3103Plant J.2017, 90(3):535-546Journal of Functional Foods2019, 52:430-441J Biosci.2020, 45:46.African J. Agricultural Research 2017, 12(13):1164-1168J of Essential Oil Research2019, 1677272Genes Genomics.2020, 10.1007
Related Screening Libraries
||Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9.|
|Planta Med. 1989 Apr;55(2):166-8. |
|Hinokiflavone, a cytotoxic principle from Rhus succedanea and the cytotoxicity of the related biflavonoids.[Pubmed: 2526343]|
|Hinokiflavone (1) was isolated as the cytotoxic principle from the drupes of Rhus succedanea L.
METHODS AND RESULTS:
A comparison of the cytotoxicity of 1 and other related biflavonoids, including amentoflavone (2), robustaflavone (3), agathisflavone (4), rhusflavone (5), rhusflavanone (6) and its hexaacetate (7), succedaneaflavanone (8) and its hexaacetate (9), cupressuflavone (10), neorhusflavanone (11), volkensiflavone (12) and its hexamethyl ether (13), spicataside (14) and its nonaacetate (15), morelloflavone (16) and its heptaacetate (17) and heptamethyl ether (18), GB-1a (19) and its hexamethyl ether (20) and 7"-O-beta-glucoside (21), and GB-2a (22), indicates that an ether linkage between two units of apigenin as seen in 1 is structurally required for significant cytotoxicity. Compounds 13 and 20 also demonstrated significant cytotoxicity.
||The leaves of Platycladus orientalis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Mol Graph Model. 2014 Apr;49:25-37. |
|Discovery of potent inhibitor for matrix metalloproteinase-9 by pharmacophore based modeling and dynamics simulation studies.[Pubmed: 24473069]|
|Matrix metalloproteinase-9 (MMP-9) is an attractive target for anticancer therapy.
METHODS AND RESULTS:
In the present study ligand based pharmacophore modeling was performed to elucidate the structural elements for a diverse class of MMP-9 inhibitors. The pharmacophore model was validated through Güner-Henry (GH) scoring method. The final pharmacophore model consisted of three hydrogen bond acceptors (HBA), and two ring aromatic regions (RA). This model was utilized to screen the natural compound database to seek novel compounds as MMP-9 inhibitors. The identified hits were validated using molecular docking and molecular dynamics simulation studies. Finally, one compound named Hinokiflavone from Juniperus communis had high binding free energy of -26.54kJ/mol compared with the known inhibitors of MMP-9. Cytotoxicity for Hinokiflavone was evaluated by MTT assay. Inhibition of MMP-9 in the presence of Hinokiflavone was detected by gelatin zymography and gelatinolytic inhibition assay.
Results revealed that the natural compounds derived based on the developed pharmacophore model would be useful for further design and development of MMP-9 inhibitors.