Science | Nature | Cell | View More
Natural Products
Trametenolic acid
Trametenolic acid
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Trametenolic acid
Price: $318 / 10mg
CAS No.: 24160-36-9
Catalog No.: CFN92366
Molecular Formula: C30H48O3
Molecular Weight: 456.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The sclerotium of Poria cocos(Schw.)Wolf
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $206.7 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Monash University (Australia)
  • Universite de Lille1 (France)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Kyung Hee University (Korea)
  • Molecular Biology Institute of ... (Spain)
  • Institute of Chinese Materia Me... (China)
  • University of Bordeaux (France)
  • S.N.D.T. Women's University (India)
  • University of Stirling (United Kingdom)
  • Gyeongsang National University (Korea)
  • University of Wuerzburg (Germany)
  • More...
Package
Featured Products
Prunasin

Catalog No: CFN97566
CAS No: 99-18-3
Price: $223/5mg
Isovalerylshikonin

Catalog No: CFN95222
CAS No: 52387-14-1
Price: $318/10mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
1,2,3,6-Tetragalloylglucose

Catalog No: CFN00447
CAS No: 79886-50-3
Price: $238/10mg
Alisol C

Catalog No: CFN92545
CAS No: 30489-27-1
Price: $318/5mg
Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg
8-Gingerol

Catalog No: CFN99131
CAS No: 23513-08-8
Price: $118/20mg
Corylin

Catalog No: CFN98902
CAS No: 53947-92-5
Price: $90/20mg
Delphinidin-3-O-galactoside chloride

Catalog No: CFN92037
CAS No: 28500-00-7
Price: $238/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.
Targets: Tyrosinase
Trametenolic acid Description
Source: The sclerotium of Poria cocos(Schw.)Wolf
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Elgonica dimer A

Catalog No: CFN95445
CAS No: 132210-48-1
Price: $368/5mg
Leachianol F

Catalog No: CFN95147
CAS No: 164123-50-6
Price: $318/5mg
Complanatoside C

Catalog No: CFN95144
CAS No: N/A
Price: $318/5mg
Obovatol

Catalog No: CFN95054
CAS No: 83864-78-2
Price: $318/5mg
Kaempferol 3-O-beta-(6''-p-coumaro...

Catalog No: CFN95089
CAS No: 111957-48-3
Price: $338/10mg
Polygalin J

Catalog No: CFN95175
CAS No: N/A
Price: $318/5mg
Epischisandrone

Catalog No: CFN95212
CAS No: 98619-26-2
Price: $413/5mg
Hainanic acid B

Catalog No: CFN95526
CAS No: 1637737-46-2
Price: $413/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1896 mL 10.9481 mL 21.8962 mL 43.7924 mL 54.7405 mL
5 mM 0.4379 mL 2.1896 mL 4.3792 mL 8.7585 mL 10.9481 mL
10 mM 0.219 mL 1.0948 mL 2.1896 mL 4.3792 mL 5.4741 mL
50 mM 0.0438 mL 0.219 mL 0.4379 mL 0.8758 mL 1.0948 mL
100 mM 0.0219 mL 0.1095 mL 0.219 mL 0.4379 mL 0.5474 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Evid Based Complement Alternat Med. 2014;2014:259836.
Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells.[Pubmed: 25197307]

METHODS AND RESULTS:
In cells testing, betulin and Trametenolic acid decreased tyrosinase activity and melanin content, while inotodiol and lanosterol significantly increased tyrosinase activity and melanin content, showing an AC⁡50 of 9.74 and 8.43 μM, respectively. Nicotinie acid, 3β,22,25-trihydroxy-lanosta-8-ene, had a little or no effect on tyrosinase. Betulin exhibited a mode of noncompetitive inhibition with a K I = K IS of 0.4 μM on tyrosinase activity showing an IC50 of 5.13 μM and being more effective than kojic acid (6.43 μM), and Trametenolic acid exhibited a mode of mixed inhibition with a K I of 0.9 μM, K IS of 0.5 μM, and an IC50 of 7.25 μM.
CONCLUSIONS:
We proposed betulin and Trametenolic acid as a new candidate of potent tyrosinase inhibitors and inotodiol and lanosterol as accelerators that could be used as therapeutic agent.
Structure Identification:
Phytochem Anal. 2011 Sep-Oct;22(5):419-23.
Rapid isolation and purification of inotodiol and trametenolic acid from Inonotus obliquus by high-speed counter-current chromatography with evaporative light scatting detection.[Pubmed: 21433158]
Inotodiol and Trametenolic acid are considered to be the main bioactive compounds of the fruiting body of the mushroom. These compounds show various biological activities, including anti-tumour, anti-viral, hypoglycaemic, anti-oxidant and cyto-protective. However, effective methods for isolating and purifying inotodiol and Trametenolic acid from the fruiting body of Inonotus obliquus are not currently available. To develop a suitable preparative method in order to isolate inotodiol and Trametenolic acid from a complex Inonotus obliquus extract by preparative high-speed counter-current chromatography (HSCCC).
CONCLUSIONS:
Inotodiol and Trametenolic acid were rapidly isolated and purified from the chloroform extract of Inonotus obliquus (Fr.) by HSCCC with evaporative light scatting detection (ELSD).The target compounds were finally isolated and purified with a solvent system of hexane:ethyl acetate:methanol:water (1:0.4:1:0.4, v/v/v/v). In a single operation, 100 mg of the I. obliquus extracts yielded 13.0 mg of inotodiol and 7.0 mg of Trametenolic acid. The entire separation and purification process took less than 5 h. The purities of obtained inotodiol and Trametenolic acid were 97.51 and 94.04%, respectively.
CONCLUSIONS:
HSCCC-ELSD was an efficient and rapid method for the separation and purification of inotodiol and Trametenolic acid from I. obliquus.
Prunasin

Catalog No: CFN97566
CAS No: 99-18-3
Price: $223/5mg
Isovalerylshikonin

Catalog No: CFN95222
CAS No: 52387-14-1
Price: $318/10mg
Procyanidin B3

Catalog No: CFN99559
CAS No: 23567-23-9
Price: $238/10mg
Ganoderenic acid A

Catalog No: CFN92236
CAS No: 100665-40-5
Price: $318/10mg
1,2,3,6-Tetragalloylglucose

Catalog No: CFN00447
CAS No: 79886-50-3
Price: $238/10mg
Alisol C

Catalog No: CFN92545
CAS No: 30489-27-1
Price: $318/5mg
Chrysosplenetin

Catalog No: CFN97026
CAS No: 603-56-5
Price: $138/20mg
8-Gingerol

Catalog No: CFN99131
CAS No: 23513-08-8
Price: $118/20mg
Corylin

Catalog No: CFN98902
CAS No: 53947-92-5
Price: $90/20mg
Delphinidin-3-O-galactoside chloride

Catalog No: CFN92037
CAS No: 28500-00-7
Price: $238/10mg
Tags: buy Trametenolic acid | Trametenolic acid supplier | purchase Trametenolic acid | Trametenolic acid cost | Trametenolic acid manufacturer | order Trametenolic acid | Trametenolic acid distributor