Fulvine | CAS:6029-87-4 | Manufacturer ChemFaces

Fulvine

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Description:

Fulvine is a hepatotoxic pyrrolizidine alkaloid. An aqueous solution of Fulvine can produce an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.

In vitro:

Toxicol Lett. 1984 May;21(2):185-9.

Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols.[Pubmed: 6426098]

METHODS AND RESULTS:
Arylthiols - in contrast to n-alkylthiols, cysteine and reduced glutathione--dehydrogenated monocrotaline, Fulvine, their N-oxides and retronecine to activated pyrrole derivatives.
CONCLUSIONS:
All thiols used failed to dehydrogenate N-methyl derivatives of monocrotaline and Fulvine.

In vivo:

Exp Pathol (Jena). 1976;12(6):329-35.

Cytotoxicity of the pyrrolizidine alkaloid fulvine to pancreatic acinar cells in the rat. Light microscopic, histochemical and ultrastructural studies.[Pubmed: 1010013]

Veno-occlusive disease of the liver is caused by the hepatotoxic pyrrolizidine alkaloid Fulvine which is found in the plant Crotolaria fulva.
METHODS AND RESULTS:
Histological, histochemical and electronmicroscopic studies carried out in Wistar rats showed that an aqueous solution of Fulvine produced an acute pancreatopathy with interstitial oedema and secondary hypoxic dystrophy of the acinar cells, when administered at doses of 10 and 20 mg/kg body weight.

Fulvine Description

Source:	The herbs of Senecio oryzetorum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Fulvine
Price:
CAS No.:	6029-87-4
Catalog No.:	CFN00370
Molecular Formula:	C₁₆H₂₃NO₅
Molecular Weight:	309.36 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Senecio oryzetorum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatotoxicity Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2325 mL	16.1624 mL	32.3248 mL	64.6496 mL	80.812 mL
5 mM	0.6465 mL	3.2325 mL	6.465 mL	12.9299 mL	16.1624 mL
10 mM	0.3232 mL	1.6162 mL	3.2325 mL	6.465 mL	8.0812 mL
50 mM	0.0646 mL	0.3232 mL	0.6465 mL	1.293 mL	1.6162 mL
100 mM	0.0323 mL	0.1616 mL	0.3232 mL	0.6465 mL	0.8081 mL

CFN00357	Crobarbatine	49679-23-4	295.33	C₁₅H₂₁NO₅
CFN00358	Crocandine	72855-83-5	311.38	C₁₆H₂₅NO₅
CFN00359	Isocrocandine	72903-70-9	311.30	C₁₆H₂₅NO₅
CFN00361	Cropodine	83601-85-8	327.37	C₁₆H₂₅NO₆
CFN00365	Crotaleschenine	120154-95-2	309.36	C₁₆H₂₃NO₅
CFN00367	Dicrotaline	480-87-5	281.31	C₁₄H₁₉NO₅
CFN00370	Fulvine	6029-87-4	309.36	C₁₆H₂₃NO₅
CFN00411	Retusine	480-86-4	311.38	C₁₆H₂₅NO₅
CFN98135	Crotaline	315-22-0	325.36	C₁₆H₂₃NO₆