ChemFaces is a professional high-purity natural products manufacturer.
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1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $144.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Faculty of Chem. & Nat. Resource ...2014...Tumour Biol.2015, 36(12):9385-93Mediators Inflamm. 2016, 2016:6189590Free Radic Biol Med.2017, 112:191-199Food Chem.2017, 221:1135-1144J Hematol Oncol.2018, 11(1):112PLoS One.2018, 13(3):e0193386European Journal of Integrative M...2018...
Molecules.2018, 23(2)Food and Fermentation Industries...2018...Drug Invention Today...2019...Asian Pac J Cancer Prev....2019...Molecules.2019, 24(24):E4536Phytother Res.2019, 33(7):1784-1793Toxicol Res.2019, 35(4):371-387Int J Cosmet Sci.2019, 41(1):12-20
Biochem Biophys Res Commun....2019...J Mol Recognit.2020, 33(2):e2819Front Microbiol.2020, 11:583594.BMC Complement Med Ther. ...2020...Molecules.2020, 25(11):2599. Molecules.2020, 25(9):2081.Chem Biol Interact.2020, 328:109200.
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Our products had been exported to the following research institutions and universities, And still growing.
Pennsylvania State University (USA)CSIRO - Agriculture Flagship (Australia)Osmania University (India)University of Padjajaran (Indonesia)
University of Bonn (Germany)Mahidol University (Thailand)University of Pretoria (South Africa)Helmholtz Zentrum München (Germany)
Ain Shams University (Egypt)Universidade Federal de Santa C... (Brazil)Uniwersytet Gdański (Poland)
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Galanthaminone
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
BMC Complement Altern Med.2019, 19(1):11Journal of Apiculture2019, 34(2):131-136Food Analytical Methods2017, 10:3225–3234Industrial Crops and Products2018, 353-362J Appl Toxicol.2020, 40(7):965-978.The Journal of Internal Korean Medicine2015, 36(4):486-497Nutrients.2020, 12(3):595.Appl Microbiol Biotechnol.2016, 100(9):3965-77Korean J Acupunct2020, 37:104-121Environ Toxicol.2019, 34(12):1354-1362
Related Screening Libraries
| Description: |
Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. |
| Targets: |
AChR | IL Receptor |
| In vitro: |
| European Journal of Drug Metabolism and Pharmacokinetics,1987,12(1):25-30. | | In vitro metabolism of galanthamine hydrobromide (Nivalin®) by rat and rabbit liver homogenate[Reference: WebLink] | The metabolism of galanthamine hydrobromide (Nivalin®) was investigated in rat and rabbit liver homogenates.
METHODS AND RESULTS:
Experiments were carried out varying several parameters of incubation: substrate (galanthamine hydrobromide, galanthamine, Galanthaminone and epigalanthamine), cofactor enrichment (NADPH, NADP/G-6-P, NAD), pH (7.4 and 9.3), time of incubation. Substrates and metabolites were identified and quantitatively determined by GC/MS. In vitro metabolism in rat liver homogenate was negligible. The experiments with rabbit liver homogenate indicated, that galanthamine was actively metabolised the major metabolites being the oxidised product — Galanthaminone, and the isomer of galanthamine — epigalantamine.
CONCLUSIONS:
The experimental results show that the metabolism of galanthamine is substrate and product stereoselective. |
|
| In vivo: |
| Clin Pharmacol Ther. 1991 Oct;50(4):420-8. | | Pharmacokinetics of galanthamine in humans and corresponding cholinesterase inhibition.[Pubmed: 1914378] |
METHODS AND RESULTS:
Measurements were done to determine the plasma concentrations of galanthamine and two of its metabolites, as well as the corresponding inhibition of acetylcholinesterase activity in erythrocytes after applying 5 and 10 mg galanthamine hydrobromide as a constant-rate intravenous infusion for 30 minutes and single oral doses of 10 mg in eight healthy male volunteers.
The data obtained revealed first-order pharmacokinetics, complete oral bioavailability, and a mean terminal half-life of 5.68 hours (95% confidence interval, 5.17 to 6.25 hours). Renal clearance accounted for only 25% of the total plasma clearance (CL = 0.34 L.kg-1.hr-1). Only negligible quantities of the putative metabolites, epigalanthamine and Galanthaminone, were detected in blood and urine. The inhibition of acetylcholinesterase activity was closely correlated with the pharmacokinetics of galanthamine, a median maximal value of 53% being achieved by applying 10 mg galanthamine intravenously.
CONCLUSIONS:
Analysis of in vitro and ex vivo concentration responses revealed no differences, indicating that no metabolites of galanthamine exert additional inhibition of acetylcholinesterase activity. |
|
Galanthaminone Description
| Source: |
The bulbs of Lycoris radiata |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.5051 mL |
17.5254 mL |
35.0508 mL |
70.1016 mL |
87.6271 mL |
| 5 mM |
0.701 mL |
3.5051 mL |
7.0102 mL |
14.0203 mL |
17.5254 mL |
| 10 mM |
0.3505 mL |
1.7525 mL |
3.5051 mL |
7.0102 mL |
8.7627 mL |
| 50 mM |
0.0701 mL |
0.3505 mL |
0.701 mL |
1.402 mL |
1.7525 mL |
| 100 mM |
0.0351 mL |
0.1753 mL |
0.3505 mL |
0.701 mL |
0.8763 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Pharmaceutical Bulletin 12(6), 696-705, 1964 | | Galanthamine Chemistry. V. Formation of Hydroxyapogalanthamine from Galanthaminone and the Synthesis of its Trimethyl Ether.[Reference: WebLink] |
METHODS AND RESULTS:
Treatment of Galanthaminone with hydriodic acid gave hydroxyapogalanthamine, the structure of which has been elucidated by degradation to the known diphenic acid (IV). The trimethyl ether of hydroxyapogalanthamine has been synthesized by two methods, confirming the structure of this important transformation product of Galanthaminone.
CONCLUSIONS:
Based on this and other chemical evidence it has been concluded that galanthamine is represented by formula (III). |
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