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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $175.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Antiviral Res.2021, 193:105142. Drug Des Devel Ther.2020, 14:5189-5204.Molecules.2019, 24(23):E4303J Vet Sci.2020, 21(3):e39.Biosci Biotechnol Biochem....2020...Front Aging Neurosci.2018, 10:269Agriculture2022, 12(2),227.Antioxidants (Basel).2020, 9(2):E99
Phytomedicine.2015, 22(4):498-503J Food Biochem.2019, 43(9):e12970Curr Top Med Chem....2020...J of the Society of Cosmetic Scie...2018...Front Plant Sci.2018, 9:1424AMB Express2020. 10(1):126.Dicle Tip Dergisi2020, 47(2),423-430.J Med Food.2016, 19(12):1155-1165
J Appl Biol Chem.2021, 64(3),263?268Nutrients.2019, 11(6):E1380J Food Sci Technol.2022, 59(1):212-219.Biomed Pharmacother.2020, 125:109784.HIV Med.2021, 22(8):690-704.Asian J Beauty Cosmetol...2020...Toxicol Res.2019, 35(4):371-387
Our products had been exported to the following research institutions and universities, And still growing.
Georgia Institute of Technology (USA)Copenhagen University (Denmark)University of Auckland (New Zealand)National Cancer Center Research... (Japan)
Sapienza University of Rome (Italy)University of Illinois (USA)Utah State University (USA)Universidad de Ciencias y Artes... (Mexico)
Lund University (Sweden)Medical University of Gdansk (Poland)University of Queensland (Australia)
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Braz J Med Biol Res.2021, 54(12):e11183.iScience.2020, 23(2):100849.Chemistry of Plant Materials.2016, 33-46Acta Chromatographica2021, 00960.Drug Chem Toxicol.2020, 1-14. J Ethnopharmacol.2021, 267:113615.Appl. Sci. 2021, 11(17),7829Antioxidants (Basel).2020, 9(2):E99J Nat Med.2022, 76(1):59-67. Mol Cells.2018, 41(8):771-780
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Coumarins Compound Library
|| Reference standards.|
| Chinese Traditional and Herbal Drugs, 2011,42(1):96-102. |
|Absorption and transportation characteristic of six linear furocoumarins in a model of Caco-2 cell monolayer in human intestine.[Reference: WebLink]|
|To study the absorption and transportation characteristic of xanthotoxol (1), xanthotoxin (2), imperatorin (3), isoimperatorin (4), cnidilin (5), and isopimpinellin (6), which were classified as the linear type furocoumarins, in a model of Caco-2 cell monolayers in human intestinal epithelium. Methods: Caco-2 (the human colon adenocarcinoma cell lines) cell monolayer was used as an intestinal epithelial cell model. The permeability of the six coumarins from apical side (AP side) to basolateral side (BL side) or from BL side to AP side was evaluated. The concentration of the six coumarins was measured by HPLC coupled with UV detector. Transportation parameters and permeability coefficients (Papp) were then calculated, and P app values were compared with the reported values for model compounds, Propranolol and Atenolol. Based on the absorption and transportation characteristic of coumarins 1-6, and psoralen (7), bergaptol (8), bergaptol-O-β-D-glucopyranoside (Bergaptol-beta-glucopyranoside
,9), bergapten (10), nodakenin (11), nodakenetin (12), decuroside V (13), umbelliferone (14), osthole (15), angelol-A (16), and angelol-B (17) in a model of Caco-2 cell monolayer, the relationship of absorption and transportation with diversed chemical structures and lipophilicity was reviewed. In the Caco-2 cell monolayer model, the Papp magnitudes of the linear furocoumarins 1-6 were 10-5 cm/s in the bi-directional transport, which was identical with Propranolol. And the permeability of Caco-2 cell monolayer is mainly via passive absorption. |
The above-mentioned linear furocoumarins 1-6 are well-absorbed compounds. The results show that a significant Sigmoid dependence of permeability on 1g Papp AP→BL and 1g D at pH 7.35 of all 1-17 furocoumarins can be absorbed across intestinal epithelial cells by passive diffusion mechanism.
||The roots of Rhodomyrtus tomentosa
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2498-502. |
|Isolation of two new coumarin glycosides from Notopterygium forbesii and evaluation of a Chinese crude drug, qiang-huo, the underground parts of N. incisum and N. forbesii, by high-performance liquid chromatography.[Pubmed: 2285981 ]|
METHODS AND RESULTS:
From the ether extract of the underground part of Notopterygium forbesii, two new coumarin glycosides, bergaptol-O-beta-D-glucopyranoside(Bergaptol-beta-glucopyranoside) and 6'-O-trans-feruloylnodakenin, were isolated along with known compounds including seven furanocoumarins, two dihydrofuranocoumarins, a sterol glucoside and two phenolic compounds. Analysis of their contents by high-performance liquid chromatography (HPLC) revealed that the underground part of N. forbesii contained large amounts of p-hydroxphenethyl anisate (0.7%), bergaptol glucoside (0.2%), nodakenin (2%) and 6'-O-trans-feruloylnodakenin (0.7%) and a lesser amount of notopterol (0.08%), while that of N. incisum contained a large amount of notopterol (1.2%) and less amounts of the others.
The characteristic difference in chemical composition between the two species enabled us to identify the respective botanical sources of a Chinese crude drug, Qiang-huo derived from N. incisum and N. forbesii by HPLC.