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    Natural Products
    Luteolin 7-diglucuronide
    Luteolin 7-diglucuronide
    Information
    CAS No. 96400-45-2 Price
    Catalog No.CFN70468Purity>=98%
    Molecular Weight638.5Type of CompoundFlavonoids
    FormulaC27H26O18Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Luteolin 7-diglucuronide

    Luteolin 7-diglucuronide
    Product Name Luteolin 7-diglucuronide
    CAS No.: 96400-45-2
    Catalog No.: CFN70468
    Molecular Formula: C27H26O18
    Molecular Weight: 638.5 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Powder
    Targets: NADPH oxidase | TGF-尾
    Source: The herbs of Aloysia triphylla
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price:
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    Description: Luteolin-7-diglucuronide( L7DG) is pharmacologically effective in protecting the heart against developing ISO-induced injury and fibrosis, justifying further evaluation of L7DG as a cardioprotective agent to treat related cardiovascular diseases.
    Targets: NADPH oxidase | TGF-β
    Luteolin 7-diglucuronide Description
    Source: The herbs of Aloysia triphylla
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5662 mL 7.8309 mL 15.6617 mL 31.3234 mL 39.1543 mL
    5 mM 0.3132 mL 1.5662 mL 3.1323 mL 6.2647 mL 7.8309 mL
    10 mM 0.1566 mL 0.7831 mL 1.5662 mL 3.1323 mL 3.9154 mL
    50 mM 0.0313 mL 0.1566 mL 0.3132 mL 0.6265 mL 0.7831 mL
    100 mM 0.0157 mL 0.0783 mL 0.1566 mL 0.3132 mL 0.3915 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Ning B B , Zhang Y , Wu D D , et al. Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice[J]. Acta Pharmacologica Sinica, 2017, 38(3):331-341.
    Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.[Reference: WebLink]
    Myocardial injury and ensuing fibrotic alterations impair normal heart architecture and cause cardiac dysfunction. Oxidative stress has been recognized as a key player in the pathogenesis of cardiac injury and progression of cardiac dysfunction, and promoting fibrosis.
    METHODS AND RESULTS:
    In the current study we investigated whether Luteolin 7-diglucuronide (L7DG), a naturally occurring antioxidant found in edible plants, could attenuate isoproterenol (ISO)-induced myocardial injury and fibrosis in mice and the underlying mechanisms. Myocardial injury and fibrosis were induced in mice via injection of ISO (5 mg·kg-1·d-1, ip) for 5 or 10 d. Two treatment regimens (pretreatment and posttreatment) were employed to administer L7DG (5-40 mg·kg-1·d-1, ip) into the mice. After the mice were euthanized, morphological examinations of heart sections revealed that both L7DG pretreatment and posttreatment regimens significantly attenuated ISO-induced myocardial injury and fibrosis. But the pretreatment regimen caused better protection against ISO-induced myocardial fibrosis than the posttreatment regimen. Furthermore, L7DG pretreatment blocked ISO-stimulated expression of the genes (Cyba, Cybb, Ncf1, Ncf4 and Rac2) encoding the enzymatic subunits of NADPH oxidase, which was the primary source of oxidant production in mammalian cells. Moreover, L7DG pretreatment significantly suppressed ISO-stimulated expression of collagen genes Col1a1, Col1a2, Col3a1, and Col12a1 and non-collagen extracellular matrix genes fibrillin-1, elastin, collagen triple helix repeat containing 1 and connective tissue growth factor. In addition, L7DG pretreatment almost reversed ISO-altered expression of microRNAs that were crosstalking with TGFβ-mediated fibrosis, including miR-29c-3p, miR-29c-5p, miR-30c-3p, miR-30c-5p and miR-21.
    CONCLUSIONS:
    The current study demonstrated for the first time that L7DG is pharmacologically effective in protecting the heart against developing ISO-induced injury and fibrosis, justifying further evaluation of L7DG as a cardioprotective agent to treat related cardiovascular diseases.
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