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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $388.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Food Science and Biotechnology...2015...Nat Plants.2016, 3:16205Current Pharmaceutical Analysis...2017...Exp Parasitol.2017, 183:160-166Evid Based Complement Alternat Me...2017...The Japan Society for Analytical ...2017...Industrial Crops and Products...2017...Drug Test Anal.2018, 10(10):1579-1589
BMC Pharmacol Toxicol.2018, 19(1):5Plant Cell Physiol.2018, 59(1):128-141J Nat Med.2018, 72(3):734-744Nutr Res Pract2019, 13:e45Microb Pathog.2019, 131:128-134Med Sci Monit.2019, 25:9499-9508The Malaysian journal of patholog...2019...J Clin Med.2019, 8(10):E1664
Planta Med.2019, 85(4):347-355Genes Genomics.2020, 10.1007Plos One.2020, 10.1371J Mol Recognit.2020, 33(2):e2819Nutrients.2020, 12(11):3448. Pharmacol Res.2020, 161:105205.Institut Pasteur Korea...2020...
Our products had been exported to the following research institutions and universities, And still growing.
Florida A&M University (USA)University of Padjajaran (Indonesia)Auburn University (USA)University of Hawaii Cancer Center (USA)
S.N.D.T. Women's University (India)Universidad Veracuzana (Mexico)University of Parma (Italy)Tokyo Woman's Christian University (Japan)
Subang Jaya Medical Centre (Malaysia)Hamdard University (India)Center for protein Engineering ... (Belgium)
Ganoderic acid H
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
China Pharmacy2015, 26(27)J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36Antioxidants (Basel).2020, 9(4):284.Anal Bioanal Chem. 2016, 408(15)Acta Pharmaceutica Hungarica2016, 86:35-40J Bone Miner Res.2017, 32(12):2415-2430Int J Biol Macromol.2020, 169:342-351J Sci Food Agric.2018, 98(3):1153-1161Molecular & Cellular Toxicology2017, 13(3):271-278J Mol Recognit.2020, 33(2):e2819
Related Screening Libraries
||Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4. |
||NF-kB | AP-1 | CDK|
|Int J Mol Med. 2008 May;21(5):577-84. |
|Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling.[Pubmed: 18425349]|
|Structurally related lanostane-type triterpenes, ganoderic acid A, F and H (GA-A, GA-F, Ganoderic acid H), were identified in an oriental medicinal mushroom Ganoderma lucidum. |
METHODS AND RESULTS:
In the present study we evaluated the effect of GA-A, Ganoderic acid H and GA-F on highly invasive human breast cancer cells. We showed that GA-A and Ganoderic acid H suppressed growth (cell proliferation and colony formation) and invasive behavior (adhesion, migration and invasion) of MDA-MB-231 cells. Our results suggest that GA-A and Ganoderic acid H mediate their biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4 and the suppression of secretion of uPA, respectively. Furthermore, the activity of ganoderic acids is linked to the hydroxylation in the position 7 and 15 (GA-A) and 3 (Ganoderic acid H) in their triterpene lanostane structure.
In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers.
Ganoderic acid H Description
||The fruit body of Ganoderma lucidum.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Nat Prod Res. 2014;28(24):2264-72. |
|Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth.[Pubmed: 25032738]|
|The response surface methodology was used to optimise the extraction conditions of Ganoderma lucidum based on a Box-Behnken design. |
METHODS AND RESULTS:
A quadratic model sufficiently simulated the response of Ganoderic acid H with a determination coefficient (R(2)) of 0.98. The optimal condition for extracting triterpenoids was determined to be 100.00% ethanol at 60.22°C for 6.00 h, under which the yield of the reference triterpenoid Ganoderic acid H increased from 0.88 to 2.09 mg/g powder. Following extraction, triterpenoid-enriched fraction was further isolated into 23 fractions, and 7 fractions were identified as ganoderic acids A, B, D, G, H and I and ganoderenic acid D. Of the seven triterpenoids, ganoderenic acid D was most cytotoxic with IC50 values of 0.14 ± 0.01, 0.18 ± 0.02 and 0.26 ± 0.03 mg/mL in Hep G2, Hela and Caco-2 cells, respectively. While ganoderic acids A, G and H were relatively non-cytotoxic.
The variation of inhibitory effects for these triterpenoids was likely related to their chemical structures.