ChemFaces is a professional high-purity natural products manufacturer.
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2. Pharmacological research
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $229.0 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Antioxidants (Basel).2021, 10(10):1620.Clin Transl Med.2021, 11(5):e392.Tumour Biol.2015, 36(9):7027-34J of Physics Conference Series...2019...University of Stuttgart2021, 11682.J Sci Food Agric.2021, Aug 21.Analytical sci. & Tech...2020...Neuropharmacology.2018, 131:68-82
J Pharmaceutical and Biomedical A...2022...Comparative Clinical Pathology ...2021...Cell Mol Biol(Noisy-le-grand)...2019...Sci Rep.2018, 8:9267Biomed Pharmacother.2022, 145:112410. BMC Complement Med Ther. ...2020...J Insect Sci.2020, 20(5):18. Environ Toxicol.2020, doi: 10.1002
Evid Based Complement Alternat Me...2018...Front Pharmacol.2020, 11:683.Food and Chemical Toxicology...2020...Aging (Albany NY)....2021...Mie University2019, 10076.J Pharm Biomed Anal.2022, 207:114398. Food Chem Toxicol.2020, 135:110863
Our products had been exported to the following research institutions and universities, And still growing.
National Cancer Institute (USA)Uniwersytet Jagielloński w Kra... (Poland)University of Stirling (United Kingdom)University of Hawaii Cancer Center (USA)
The Vancouver Prostate Centre (... (Canada)Leibniz-Institut für Pflanzenb... (Germany)Universitas islam negeri Jakarta (Indonesia)University of Beira Interior (Portugal)
Universit?t Basel (Switzerland)University of Zurich (Switzerland)Kitasato University (Japan)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Saudi Pharm J.2019, 27(1):145-153Pharmaceuticals (Basel).2021, 14(3):260.Appl. Sci.2020, 10,1304Biomolecules.2020, 10(2):E184Phytomedicine.2019, 59:152785Int J Mol Sci.2018, 19(2)Ulm University Medical Center2020, doi: 10.18725.Sci Rep.2017, 7:40345J Nat Med.2020, 74(1):65-75FASEB J.2019, 33(8):9685-9694
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Coumarins Compound Library
|| Reference standards.|
||The roots of Angelica decursiva
||DMSO, Pyridine, Methanol, Ethanol, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chem Pharm Bull (Tokyo). 1990 Sep;38(9):2498-502. |
|Isolation of two new coumarin glycosides from Notopterygium forbesii and evaluation of a Chinese crude drug, qiang-huo, the underground parts of N. incisum and N. forbesii, by high-performance liquid chromatography.[Pubmed: 2285981]|
METHODS AND RESULTS:
From the ether extract of the underground part of Notopterygium forbesii, two new coumarin glycosides, bergaptol-O-beta-D-glucopyranoside and 6'-O-trans-feruloylnodakenin(6'-Feruloylnodakenin), were isolated along with known compounds including seven furanocoumarins, two dihydrofuranocoumarins, a sterol glucoside and two phenolic compounds. Analysis of their contents by high-performance liquid chromatography (HPLC) revealed that the underground part of N. forbesii contained large amounts of p-hydroxphenethyl anisate (0.7%), bergaptol glucoside (0.2%), nodakenin (2%) and 6'-O-trans-feruloylnodakenin (0.7%) and a lesser amount of notopterol (0.08%), while that of N. incisum contained a large amount of notopterol (1.2%) and less amounts of the others.
The characteristic difference in chemical composition between the two species enabled us to identify the respective botanical sources of a Chinese crude drug, Qiang-huo derived from N. incisum and N. forbesii by HPLC.
| Chinese Traditional and Herbal Drugs, 2009. |
|Absorption and transportation characteristic of dihydrofurocoumarins from Rhizome et Radix Notopterygii in a model of Caco-2 cell monolayers.[Reference: WebLink]|
|To study the absorption and transportation characteristic of nodakenetin (NANI), nodakenin (ND), decuroside V (DEV), and forbesoside [6′-O-(trans-feruloyl)-nodakenin, 6'-Feruloylnodakenin FDE] isolated from Rhizome et Radix Notopterygii, which were classified four linear dihydrofurocouma-rins, in human intestinal epithelium. |
METHODS AND RESULTS:
Caco-2 (the human colon adenocarcinoma cell lines) cell monolayers were used as an intestinal epithelial cell model. The permeability of the four coumarins from apical side (AP side) to basolateral side (BL side) or from BL side to AP side was evaluated. The concentration of the four coumarins was measured by HPLC coupled with UV detector. Transportation parameters and permeability coefficients (Papp) were then calculated, and Papp values were compared with the reported values for model compounds, propranolol, and atenolol. The Papp values of NANI in the bi-directional transportation were quantitative degree of 1×106cm/s, which laid between propranolol often used as a control substance for high permeability and Atenolol often used as a control substance for poor permeability. Whereas Papp values of ND, DEV, and FDE were quantitative degree of 1×107cm/s, which was comparable with the Papp values of atenolol. The absorption and transportation of four coumarins were positive correlation to the concentration of 25-400 μmol/L.
Four linear dihydrofurocoumarins can be absorbed across intestinal epithelial cells by passive diffusion mechanism. The NANI is moderately, while ND, DEV, and FDE are poorly absorbed compounds.