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3. Inhibitors
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $96.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Life (Basel).2022, 12(10):1630.Molecular & Cellular Toxicology...2017...J Nat Prod.2018, 81(4):966-975Front Plant Sci.2022, 13: 905275.Eur Endod J.2020, 5(1):23-27.Biomedicine & Pharmacotherapy...2020...Advances in Traditional Medicine...2020...US20170000760 A12016, 42740
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Subang Jaya Medical Centre (Malaysia)Johannes Gutenberg University M... (Germany)Aveiro University (Portugal)Sanford Burnham Prebys Medical ... (USA)
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5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
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Molecules.2018, 23(2)Biochem Biophys Res Commun.2018, 495(1):1271-1277J Ethnopharmacol.2017, 206:73-77Nat Prod Sci.2018, 24(2):109-114Cell Biochem Funct.2018, 36(6):303-311Biology (Basel).2020, 9(11):363. Biochem Biophys Res Commun.2019, 518(4):732-738Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.Appl Microbiol Biotechnol.2016, 100(9):3965-77Advances in Traditional Medicine2020, 10.1007
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
| Description: |
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity. |
| In vitro: |
| Biol Pharm Bull. 2004 Jan;27(1):138-40. | | 5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum.[Pubmed: 14709919 ] |
METHODS AND RESULTS:
A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH)[5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA)
], from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC(50) value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice.
CONCLUSIONS:
Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents. |
|
5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) Description
| Source: |
The rhizomes of Curcuma longa L. |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.0451 mL |
15.2253 mL |
30.4507 mL |
60.9013 mL |
76.1267 mL |
| 5 mM |
0.609 mL |
3.0451 mL |
6.0901 mL |
12.1803 mL |
15.2253 mL |
| 10 mM |
0.3045 mL |
1.5225 mL |
3.0451 mL |
6.0901 mL |
7.6127 mL |
| 50 mM |
0.0609 mL |
0.3045 mL |
0.609 mL |
1.218 mL |
1.5225 mL |
| 100 mM |
0.0305 mL |
0.1523 mL |
0.3045 mL |
0.609 mL |
0.7613 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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