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    Natural Products
    Glycyrrhizic acid ammonium salt
    Information
    CAS No. 53956-04-0 Price $40 / 20mg
    Catalog No.CFN99153Purity>=98%
    Molecular Weight839.96Type of CompoundTriterpenoids
    FormulaC42H65NO16Physical DescriptionWhite powder
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    Glycyrrhizic acid ammonium salt

    Glycyrrhizic acid ammonium salt
    Product Name Glycyrrhizic acid ammonium salt
    CAS No.: 53956-04-0
    Catalog No.: CFN99153
    Molecular Formula: C42H65NO16
    Molecular Weight: 839.96 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: White powder
    Targets: ROS
    Source: The roots of Glycyrrhiza glabra L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $40 / 20mg
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Wound-healing Compound Library
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  • Biological Activity
    Description: Glycyrrhizic acid ammonium salt has wound healing activity.
    Targets: ROS
    In vivo:
    Eksp Klin Farmakol. 2014;77(9):38-42.
    Study of the influence of original multicomponent gels on the process of pathological scar formation using new methodological approach.[Pubmed: 25365869]
    A new method of the quantitative macroscopic assessment of the process of a complex infected wound healing has been created. It was verified by example of the influence of original multicomponent gels consisting of cycloferon, amino acid glycine, glycyram (Glycyrrhizic acid ammonium salt), and vegetable oils on the process of infected wound healing and pathological scar formation. Simultaneously, the wound healing was monitored by the conventional histomorphological method. The proposed gels more effectively prevent the formation of pathological scars in comparison to reference preparation Contractubex.
    Evid Based Complement Alternat Med . 2015;2015:272474.
    Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway[Pubmed: 25866535]
    Abstract The present study aimed to investigate the therapeutic effect of monoammonium glycyrrhizinate (MAG) on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice and possible mechanism. Acute lung injury was induced in BALB/c mice by intratracheal instillation of LPS, and MAG was injected intraperitoneally 1 h prior to LPS administration. After ALI, the histopathology of lungs, lung wet/dry weight ratio, protein concentration, and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined. The levels of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the BALF were measured by ELISA. The activation of NF-κB p65 and IκB-α of lung homogenate was detected by Western blot. Pretreatment with MAG attenuated lung histopathological damage induced by LPS and decreased lung wet/dry weight ratio and the concentrations of protein in BALF. At the same time, MAG reduced the number of inflammatory cells in lung and inhibited the production of TNF-α and IL-1β in BALF. Furthermore, we demonstrated that MAG suppressed activation of NF-κB signaling pathway induced by LPS in lung. The results suggested that the therapeutic mechanism of MAG on ALI may be attributed to the inhibition of NF-κB signaling pathway. Monoammonium glycyrrhizinate may be a potential therapeutic reagent for ALI.
    Pharm Biol . 2016;54(6):931-7.
    Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver[Pubmed: 26987268]
    Abstract Context: Drug-induced liver injury (DILI) is associated with altering expression of hepatobiliary membrane transporters. Monoammonium glycyrrhizin (MAG) is commonly used for hepatic protection and may have a correlation with the inhibition effect of multidrug resistance-associated protein 2 (Mrp2). Objective: This study evaluates the dynamic protective effect of MAG on rifampicin (RIF)- and isoniazid (INH)-induced hepatotoxicity in rats. Materials and methods: Male Wistar rats were randomly divided into four groups of 15 rats. Liver injury was induced by co-treatment with RIF (60 mg/kg) and INH (60 mg/kg) by gavage administration; MAG was orally pretreated at the doses of 45 or 90 mg/kg 3 h before RIF and INH. Rats in each group were sacrificed at 7, 14, and 21 d time points after drug administration. Results: Liver function, histopathological analysis, and oxidative stress factors were significantly altered in each group. The expression of Mrp2 was significantly increased 230, 760, and 990% at 7, 14, and 21 time points, respectively, in RIF- and INH-treated rats. Compared with the RIF and INH groups, Mrp2 was reduced and Ntcp was significantly elevated by 180, 140, and 160% in the MAG high-dose group at the three time points, respectively. The immunoreaction intensity of Oatp1a4 was increased 170, 190, and 370% in the MAG low-dose group and 160, 290, and 420% in the MAG high-dose group at the three time points, respectively, compared with the RIF and INH groups. Discussion and conclusion: These results indicated that MAG has a protective effects against RIF- and INH-induced hepatotoxicity. The underlying mechanism may have correlation with its effect on regulating the expression of hepatobiliary membrane transporters. Keywords: Anti-tuberculosis agent; glycyrrhizin acid; hepatoprotective; liver injury.
    Glycyrrhizic acid ammonium salt Description
    Source: The roots of Glycyrrhiza glabra L.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.1905 mL 5.9527 mL 11.9053 mL 23.8107 mL 29.7633 mL
    5 mM 0.2381 mL 1.1905 mL 2.3811 mL 4.7621 mL 5.9527 mL
    10 mM 0.1191 mL 0.5953 mL 1.1905 mL 2.3811 mL 2.9763 mL
    50 mM 0.0238 mL 0.1191 mL 0.2381 mL 0.4762 mL 0.5953 mL
    100 mM 0.0119 mL 0.0595 mL 0.1191 mL 0.2381 mL 0.2976 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Animal Research:
    Ijrpbsonline Com., 2011.
    Pharmacological Investigation on the Wound Healing Effects of Glycyrrhizic Acid Ammonium Salt in Rats.[Reference: WebLink]
    Wound healing process involves several steps, which involves coagulation, inflammation, formation of granulation tissue, matrix formation, remodeling of connective tissue, collagenisation and aquisation of wound strength.Wound healing activity of GA was Glycyrrhizic acid ammonium salt (GA) studied in terms of 1) % wound contraction, 2) epithelization, 3) wound breaking strength in incision and excision wound models. In the standard group the rats were treated with 0.0005% w/w fluticasone ointment for 10 days in incision model and for 16 days in excision model. In the test group, the rats were treated with 2% w/w GA ointment for 10 days in incision model and for 16 days in excision model.
    CONCLUSIONS:
    In this study we have demonstrated the effect of Glycyrrhizic acid ammonium salt on excision and incision wound healing models that GA show increase the % wound contraction, epithelization and wound breaking strength as compared to control group
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