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    Natural Products
    Grosvenorin
    Grosvenorin
    Information
    CAS No. 156980-60-8 Price $288 / 10mg
    Catalog No.CFN99772Purity>=98%
    Molecular Weight740.7Type of CompoundFlavonoids
    FormulaC33H40O19Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $204.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
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    Grosvenorin

    Grosvenorin
    Product Name Grosvenorin
    CAS No.: 156980-60-8
    Catalog No.: CFN99772
    Molecular Formula: C33H40O19
    Molecular Weight: 740.7 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: Antifection
    Source: The fruits of Siraitia grosuenorii
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $288 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Asian J Beauty Cosmetol2019, 17(3):287-294
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  • Molecules.2020, 25(21):5091.
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
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  • Biological Activity
    Description: Grosvenorine exhibits good antibacterial and antioxidant activities, with its metabolites possessing more potent activities, intestinal bacteria play an important role in the gastrointestinal metabolism of grosvenorine and significantly affect its pharmacological activities.
    Targets: Antifection
    In vitro:
    Chem Biodivers. 2015 Nov;12(11):1652-64.
    The Gastrointestinal Tract Metabolism and Pharmacological Activities of Grosvenorine, a Major and Characteristic Flavonoid in the Fruits of Siraitia grosvenorii.[Pubmed: 26567944 ]
    Grosvenorine is the major flavonoid compound of the fruits of Siraitia grosvenorii (Swingle) C. Jeffrey, a medical plant endemic to China.
    METHODS AND RESULTS:
    In the present study, for the first time, the Grosvenorine metabolism in an in vitro simulated human gastrointestinal tract (including artificial gastric juice, artificial intestinal juice and intestinal flora), as well as its pharmacological activities (including anti-complement, antibacterial and antioxidant activities), was investigated. The results showed that Grosvenorine was metabolized by human intestinal flora; its four metabolites were isolated by semi-preparative HPLC and identified by NMR as kaempferitrin, afzelin, α-rhamnoisorobin, and kaempferol. Further pharmacological evaluation showed that Grosvenorine exhibited good antibacterial and antioxidant activities, with its metabolites possessing more potent activities. Although Grosvenorine did not present obvious anticomplement activity, its metabolites showed interesting activities.
    CONCLUSIONS:
    This study revealed that intestinal bacteria play an important role in the gastrointestinal metabolism of Grosvenorine and significantly affect its pharmacological activities.
    Grosvenorin Description
    Source: The fruits of Siraitia grosuenorii
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.3501 mL 6.7504 mL 13.5007 mL 27.0015 mL 33.7519 mL
    5 mM 0.27 mL 1.3501 mL 2.7001 mL 5.4003 mL 6.7504 mL
    10 mM 0.135 mL 0.675 mL 1.3501 mL 2.7001 mL 3.3752 mL
    50 mM 0.027 mL 0.135 mL 0.27 mL 0.54 mL 0.675 mL
    100 mM 0.0135 mL 0.0675 mL 0.135 mL 0.27 mL 0.3375 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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