ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
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Sent to Email: info@chemfaces.com
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Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $229.0 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Molecules. 2013, 18(7):7376-88Phytomedicine.2015, 22(4):498-503Korean J. of Food Sci. and Tech...2016...Nat Prod Sci.2016, 22(2)Biomed Chromatogr.2016, 30(10):1573-81J of the Korean Society of Food S...2016...Evid Based Complement Alternat Me...2018...Molecules.2018, 23(2)
Korean J Environ Agric....2018...World J Mens Health.2019, 10.5534Biomed Pharmacother.2019, 116:108987Front Neurosci.2019, 13:1091Nutr Metab (Lond).2019, 16:31Asian J Beauty Cosmetol...2019...BMC Complement Altern Med....2019...J Ethnopharmacol.2019, 244:112074
Pak J Pharm Sci.2019, 32(6):2879-2885Phytomedicine.2019, 61:152813Dent Mater J.2020, 39(4):690-695Int J Mol Sci.2020, 21(8):2790.Int J Mol Sci.2020, 21(9):3239.Food Chem.2020, 327:126992.Antioxidants (Basel).2020, 9(11):1121.
More...
Our products had been exported to the following research institutions and universities, And still growing.
Seoul National University (Korea)University of Bonn (Germany)Chang Gung University (Taiwan)Siksha O Anusandhan University (India)
National Cancer Center Research... (Japan)Uniwersytet Gdański (Poland)Shanghai University of TCM (China)Instituto Politécnico de Bragan?a (Portugal)
University of Fribourg (Switzerland)Korea Institute of Oriental Med... (Korea)John Innes Centre (United Kingdom)
More...
Glucoliquiritin
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
BMC Complement Altern Med.2019, 19(1):325Nutrients.2017, 10(1)J Ethnopharmacol.2019, 236:31-41Drug Invention Today2019, 12(6):1303-1306University of Central Lancashire2017, 20472Drug Dev Res.2020, doi: 10.1002Appl Microbiol Biotechnol.2018, 102(12):5105-5120Microb Pathog.2019, 131:128-134Inflammation.2021, doi: 10.1007J Biomed Sci.2020, 27(1):60.
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Flavonoids Compound Library |
| Description: |
Reference standards. |
Glucoliquiritin Description
| Source: |
The roots of Glycyrrhiza glabra L. |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.7227 mL |
8.6133 mL |
17.2265 mL |
34.4531 mL |
43.0663 mL |
| 5 mM |
0.3445 mL |
1.7227 mL |
3.4453 mL |
6.8906 mL |
8.6133 mL |
| 10 mM |
0.1723 mL |
0.8613 mL |
1.7227 mL |
3.4453 mL |
4.3066 mL |
| 50 mM |
0.0345 mL |
0.1723 mL |
0.3445 mL |
0.6891 mL |
0.8613 mL |
| 100 mM |
0.0172 mL |
0.0861 mL |
0.1723 mL |
0.3445 mL |
0.4307 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Kinase Assay: |
| Biological & Pharmaceutical Bulletin, 2005, 28(10):2000-2002. | | CYP3A4 inhibitors isolated from Licorice.[Reference: WebLink] | The extract of licorice (Glycyrrhiza uralensis FISHER, Leguminosae) showed CYP3A4 inhibitory activity with the IC50 value of 0.022 mg/ml.
METHODS AND RESULTS:
Bioassay-guided purification afforded nine compounds, 3-(p-hydroxyphenyl)propionic acid (1), isoliquiritigenin (2), (3R)-vestitol (3), licopyranocoumarin (4), 4-hydroxyguaiacol apioglucoside (5), liquiritin (6), liquiritigenin 7,4'-diglucoside (7), liquiritin apioside (8), and Glucoliquiritin apioside (9).
CONCLUSIONS:
Among these compounds, 3, 7, and 5 showed potent CYP3A4 inhibitory activities with IC50 values of 3.6, 17, and 20 microM, respectively. Glycyrrhizin (10), a main constituent of licorice, however, was inactive for CYP3A4 inhibition.
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