Science | Nature | Cell | View More
Natural Products
Guajadial D
Guajadial D
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Guajadial D
Price:
CAS No.: 1529775-04-9
Catalog No.: CFN89480
Molecular Formula: C30H34O5
Molecular Weight: 474.58 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The leaves of Psidium guajava.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • University of Otago (New Zealand)
  • The Institute of Cancer Research (United Kingdom)
  • Universidade Federal de Pernamb... (Brazil)
  • University of Zurich (Switzerland)
  • Molecular Biology Institute of ... (Spain)
  • Gyeongsang National University (Korea)
  • China Medical University (Taiwan)
  • University of Illinois at Chicago (USA)
  • Institute of Pathophysiology Me... (Austria)
  • University of Wuerzburg (Germany)
  • Chiang Mai University (Thailand)
  • More...
Package
Featured Products
Angoroside C

Catalog No: CFN98149
CAS No: 115909-22-3
Price: $98/20mg
Procyanidin B4

Catalog No: CFN91171
CAS No: 29106-51-2
Price: $288/10mg
Platycodigenin

Catalog No: CFN92207
CAS No: 22327-82-8
Price: $268/10mg
Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg
Maackiain

Catalog No: CFN99746
CAS No: 19908-48-6
Price: $100/20mg
Irisflorentin

Catalog No: CFN99788
CAS No: 41743-73-1
Price: $40/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Kaempferol

Catalog No: CFN98838
CAS No: 520-18-3
Price: $30/20mg
8-Prenylnaringenin

Catalog No: CFN92016
CAS No: 53846-50-7
Price: $108/10mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Guajadial D shows cytotoxicity against five human cancer cell lines.
In vitro:
J Agric Food Chem. 2017 Jun 21;65(24):4993-4999.
Meroterpenoids with Antitumor Activities from Guava (Psidium guajava).[Pubmed: 28578580 ]
Psidium guajava L., a species native to South America, has been widely cultivated in the tropical and subtropical areas of China for its popular fruits.
METHODS AND RESULTS:
The preliminary analysis by liquid chromatography-ultraviolet (LC-UV) indicated the presence of meroterpenoids in the fruits of P. guajava (guava). Subsequent fractionation of the petroleum ether extract resulted in the identification of two new meroterpenoids, psiguajavadials A (1) and B (2), together with 14 previously described meroterpenoids (3-16, including guajadial A, guajadial B , Guajadial C , Guajadial D, guajadial E and guajadial F). Their structures were fully elucidated by comprehensive spectroscopic techniques and theoretical calculations. All of the meroterpenoids showed cytotoxicities against five human cancer cell lines, with guajadial B (12) being the most effective having an IC50 value of 150 nM toward A549 cells. Furthermore, biochemical topoisomerase I (Top1) assay revealed that psiguajavadial A (1), psiguajavadial B (2), guajadial B (12), Guajadial C (14), and guajadial F (16) acted as Top1 catalytic inhibitors and delayed Top1 poison-mediated DNA damage. The flow cytometric analysis indicated that the new meroterpenoids psiguajavadials A (1) and B (2) could induce apoptosis of HCT116 cells.
CONCLUSIONS:
These data suggest that meroterpenoids from guava fruit could be used for the development of antitumor agents.
Guajadial D Description
Source: The leaves of Psidium guajava.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Eschweilenol C

Catalog No: CFN95363
CAS No: 211371-02-7
Price: $318/10mg
Pinocembrin 7-O-(4'',6''-hexahydro...

Catalog No: CFN95462
CAS No: 1825287-22-6
Price: $318/10mg
Kaempferol 3,5-O-diglucoside

Catalog No: CFN95487
CAS No: 205103-97-5
Price: $318/5mg
Prionanthoside

Catalog No: CFN95206
CAS No: 161842-81-5
Price: $318/5mg
Licoricesaponin H2

Catalog No: CFN95173
CAS No: 118441-85-3
Price: $218/10mg
Methyl ganoderate B

Catalog No: CFN95551
CAS No: 81907-65-5
Price: $413/5mg
New compound 19

Catalog No: CFN95538
CAS No: N/A
Price: $413/5mg
Isolappaol A

Catalog No: CFN95224
CAS No: 131400-96-9
Price: $333/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1071 mL 10.5356 mL 21.0713 mL 42.1425 mL 52.6782 mL
5 mM 0.4214 mL 2.1071 mL 4.2143 mL 8.4285 mL 10.5356 mL
10 mM 0.2107 mL 1.0536 mL 2.1071 mL 4.2143 mL 5.2678 mL
50 mM 0.0421 mL 0.2107 mL 0.4214 mL 0.8429 mL 1.0536 mL
100 mM 0.0211 mL 0.1054 mL 0.2107 mL 0.4214 mL 0.5268 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Bioprospect. 2013 Feb; 3(1): 14–19.
Guajadials C-F, four unusual meroterpenoids from Psidium guajava.[Reference: WebLink]

METHODS AND RESULTS:
Guajadial C, Guajadial D, Guajadial E, Guajadial F (1–4), four sesquiterpenoid-based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava.
CONCLUSIONS:
Their structures and relative configurations were established by extensive spectroscopic analysis. A possible biosynthetic pathway for 1–4 was also proposed.
Angoroside C

Catalog No: CFN98149
CAS No: 115909-22-3
Price: $98/20mg
Procyanidin B4

Catalog No: CFN91171
CAS No: 29106-51-2
Price: $288/10mg
Platycodigenin

Catalog No: CFN92207
CAS No: 22327-82-8
Price: $268/10mg
Saponin

Catalog No: CFN70204
CAS No: 8047-15-2
Price: $30/20mg
Maackiain

Catalog No: CFN99746
CAS No: 19908-48-6
Price: $100/20mg
Irisflorentin

Catalog No: CFN99788
CAS No: 41743-73-1
Price: $40/20mg
Saikosaponin D

Catalog No: CFN99989
CAS No: 20874-52-6
Price: $40/20mg
Stevenleaf

Catalog No: CFN99189
CAS No: 80321-63-7
Price: $ / mg
Kaempferol

Catalog No: CFN98838
CAS No: 520-18-3
Price: $30/20mg
8-Prenylnaringenin

Catalog No: CFN92016
CAS No: 53846-50-7
Price: $108/10mg
Tags: buy Guajadial D | Guajadial D supplier | purchase Guajadial D | Guajadial D cost | Guajadial D manufacturer | order Guajadial D | Guajadial D distributor