ChemFaces is a professional high-purity natural products manufacturer.
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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $28.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Cell Prolif.2021, 54(8):e13083.Acta Pharmaceutica Hungarica...2016...Int J Mol Sci.2021, 22(2):770.J Nat Med.2018, 72(3):734-744J Ethnopharmacol.2020, 254:112733. J Mass Spectrom.2022, 57(2):e4810.Biol Pharm Bull.2018, 41(11):1645-1651Plant Pathology2022, 13527
Acta horticulturae2017, 1158:257-268Chung Shan Medical University...2020...J Am Soc Mass Spectrom....2021...Molecules.2016, 21(6)Phytomedicine.2018, 41:62-66Plants (Basel).2020, 9(11):1422.Int J Mol Sci.2020, 21(9):3144.Neurochem Int.2018, 121:114-124
China Pharmacy2015, 26(27)Food Addit Contam Part A Chem Ana...2020...The Journal of Animal & Plant Sci...2020...Vojnosanit Pregl2016, 75(00):391-391Biochem Pharmacol. 2020, 177:114014.Phytomedicine.2021, 83:153483. BMC Complement Altern Med....2019...
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Our products had been exported to the following research institutions and universities, And still growing.
Monash University Malaysia (Malaysia)University of Bordeaux (France)Universidad Industrial de Santa... (Colombia)Anna University (India)
University of Hull (United Kingdom)Amity University (India)CSIRO - Agriculture Flagship (Australia)University of Lodz (Poland)
University of Cincinnati (USA)University of Parma (Italy)University of British Columbia (Canada)
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Syringin
Inquire / Order:
manager@chemfaces.com
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service@chemfaces.com
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+86-27-84254680
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Free Radic Biol Med.2016, 97:307-319Biochemical Systematics and Ecology2018, 81J Ethnopharmacol.2017, 209:305-316Pharmaceutics2022, 14(2),376.Int J Mol Sci.2018, 19(9):E2681Int J Mol Sci.2019, 20(14):E3538Russian J Bioorganic Chemistry 2021, 47:1411-1417.Molecules.2019, 24(10):E1926Separations2021, 8(1), 1.Molecules.2020, 25(9):2081.
Related Screening Libraries
| Description: |
Syringin (Eleutheroside B) has neuroprotective, tonic, adaptogenic, antitumour, anti- platelet aggregation, anti-inflammatory, antinociceptive ,and immune-modulating properties. It reduced the expression levels of inducible NO synthase (iNOS) ,COX,TNF-α, Beta Amyloid, and Caspase. |
| Targets: |
TNF-α | Beta Amyloid | Caspase | COX | NOS |
| In vitro: |
| Arch Pharm Res. 2010 Apr;33(4):531-8. | | Syringin from stem bark of Fraxinus rhynchophylla protects Abeta(25-35)-induced toxicity in neuronal cells.[Pubmed: 20422361] | The medicinal herb Jinpi, derived from the dried stem barks of Fraxinus rhynchophylla belonging to Oleaceae is widely used as a variety of Korean folk remedies for anti-inflammatory, febricide, antidiarrhea, and antileukorrhea diseases.
METHODS AND RESULTS:
In the course of screening antidementia agents from natural products, F. rhynchophylla showed significant inhibitory activity toward Abeta(25-35)-induced neuronal cell death. An active principle was isolated and identified as Syringin.When the neuroblastoma cells were exposed to 50 microM Abeta(25-35), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction rate (survival rate) decreased to 60.21 +/- 2.16% over control while Syringin treated ones recovered cell viability up to 79.12 +/- 1.39% at 20 microM. In addition, 20 microM Syringin almost completely removed Abeta(25-35)-induced reactive oxygen species. The neuroprotective effect of Syringin seemed to be originated from the reduction of apoptosis since decrease in caspase-3 activity and expression, reduction in cleaved PARP, and DNA fragmentation were observed.
CONCLUSIONS:
These results suggest that F. rhynchophylla and Syringin are expected to be useful for preventing Abeta(25-35)-induced neuronal cell damage. |
|
| In vivo: |
| Fundam Clin Pharmacol. 2015 Apr;29(2):178-84. | | Syringin may exert sleep-potentiating effects through the NOS/NO pathway.[Pubmed: 25377727] | Sleep is essential for basic survival as well as for optimal physical and cognitive performance in both human beings and animals.
METHODS AND RESULTS:
To investigate the effect of Syringin on sleep of anesthetized mice and the potential mechanisms, 35 male Kunming mice were randomly divided into six experimental groups (n = 5) and one control group (n = 5). Sleep latency and sleep duration, as well as nitric oxide (NO) content and nitric oxide synthase (NOS) activity, were determined after Syringin administration. The NO precursor l-Arginine (l-Arg) or NOS inhibitor NG-Nitro-l-arginine methyl ester (l-NAME) was administered alone or in combination with Syringin, and time for sleep latency and duration was recorded. After intragastric administration of Syringin, sleep latency decreased in a dose- and time-dependent manner, concomitant with increased sleep duration. The optimal sleep performance was obtained when Syringin was given at a dose of 80 mg/kg for eight consecutive days. Syringin significantly reduced NO concentration and NOS activity. Administration of l-Arg prolonged sleep latency and shortened sleep duration, and the effects were fully reversed by Syringin coadministration. Administration of L-NAME induced a significant reduction in sleep latency and a corresponding increase in sleep duration, and coadministration of Syringin further enhanced the effects.
CONCLUSIONS:
The finding of our study demonstrated that Syringin could exert sleep-potentiating effects on anesthetized mice in a time- and dose-dependent manner, and these effects may be intimately correlated with the NO/NOS pathway. |
|
Syringin Description
| Source: |
The fruits of Syringa vulgaris |
| Solvent: |
DMSO, Pyridine, Methanol, Ethanol, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.6853 mL |
13.4264 mL |
26.8528 mL |
53.7057 mL |
67.1321 mL |
| 5 mM |
0.5371 mL |
2.6853 mL |
5.3706 mL |
10.7411 mL |
13.4264 mL |
| 10 mM |
0.2685 mL |
1.3426 mL |
2.6853 mL |
5.3706 mL |
6.7132 mL |
| 50 mM |
0.0537 mL |
0.2685 mL |
0.5371 mL |
1.0741 mL |
1.3426 mL |
| 100 mM |
0.0269 mL |
0.1343 mL |
0.2685 mL |
0.5371 mL |
0.6713 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Animal Research: |
| Planta Med. 2004 Nov;70(11):1027-32. | | Anti-inflammatory and antinociceptive effects of sinapyl alcohol and its glucoside syringin.[Pubmed: 15549657] | In the present study, Syringin, isolated by activity-guided fractionation of the ethyl acetate (EtOAc) extracts of the stem bark of Magnolia sieboldii, and sinapyl alcohol, the hydrolysate of Syringin, were evaluated for anti-inflammatory and antinociceptive activities.
METHODS AND RESULTS:
Sinapyl alcohol (20, 30 mg/kg/day, p. o.) inhibited increased vascular permeability by acetic acid in mice and reduced acute paw edema by carrageenan in rats more so than Syringin. When analgesic activity was measured using the acetic acid-induced writhing test and the hot plate test, sinapyl alcohol was much more potent than Syringin in a mouse model. In addition, sinapyl alcohol more potently inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor (TNF)-alpha production by macrophages than Syringin. Consistent with these observations, the expression levels of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 was reduced by sinapyl alcohol in a concentration-dependent manner.
CONCLUSIONS:
These results suggest that the anti-inflammatory and antinociceptive effects of Syringin after oral administration may be attributed to its in vivo transformation to sinapyl alcohol. | | J Appl Toxicol. 2014 Mar;34(3):265-71. | | Hepatoprotective effects of syringin on fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide in mice.[Pubmed: 23620140] | Animal Models: BALB/c mice
Formulation: ---
Dosages:10, 30 and 100 mg/kg
Administration: i.p.
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