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    Cordifolioside A
    Cordifolioside A
    Information
    CAS No. 155179-20-7 Price $368 / 10mg
    Catalog No.CFN95040Purity>=98%
    Molecular Weight504.5Type of CompoundPhenylpropanoids
    FormulaC22H32O13Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $265.0 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Cordifolioside A

    Cordifolioside A
    Product Name Cordifolioside A
    CAS No.: 155179-20-7
    Catalog No.: CFN95040
    Molecular Formula: C22H32O13
    Molecular Weight: 504.5 g/mol
    Purity: >=98%
    Type of Compound: Phenylpropanoids
    Physical Desc.: Powder
    Targets: Immunology & Inflammation related
    Source: The herbs of Tinospora cordifolia
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $368 / 10mg
    Inquire / Order: manager@chemfaces.com
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Phenylpropanoids Compound Library
  • Immunology & Inflammation related Inhibitor Library
  • Biological Activity
    Description: Cordifolioside A possesses immunomodulatory activity, it has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.
    Targets: Immunology & Inflammation related
    In vitro:
    J Ethnopharmacol. 2012 Jun 14;141(3):918-26.
    Immunomodulatory active compounds from Tinospora cordifolia.[Pubmed: 22472109]
    Tinospora cordifolia mentioned as "Rasayana" is extensively used in various herbal preparations for the treatment of different ailments for its general tonic, antiperiodic, antispasmodic, antiinflammatory, antiarthritic, antiallergic and antidiabetic properties. It is extensively used in Ayurveda due to its potential in improving the immune system and the body resistance against infections. The aim of the study was to isolate and characterise the immunomodulatory active compounds of Tinospora cordifolia.
    METHODS AND RESULTS:
    The immunomodulatory activity of different extracts, fractions and isolated compounds in relation to phagocytosis and reactive oxygen species production in human neutrophil cells have been investigated using the PMN phagocytic function studies, NBT, NO and chemiluminescence assay. The results obtained indicate that ethyl acetate, water fractions and hot water extract exhibited significant immunomodulatory activity with an increase in percentage phagocyctosis. Chromatographic purification of these fraction led to the isolation of a mixture of two compounds 2, 3 isolated for the first time from natural source and five known compounds 1, 4-7 which were characterized as 11-hydroxymustakone (2), N-methyl-2-pyrrolidone (3), N-formylannonain (1), Cordifolioside A (4), magnoflorine (5), tinocordiside (6), syringin (7) by nuclear magnetic resonance (NMR) and mass spectrometry (MS) and comparing the spectral data with reported one. Cordifolioside A and syringin have been reported to possess immunomodulatory activity. Other five compounds showed significant enhancement in phagocytic activity and increase in nitric oxide and reactive oxygen species generation at concentration 0.1-2.5 μg/ml.
    CONCLUSIONS:
    Seven immunomodulatory active compounds belonging to different classes have been isolated and characterised indicating that the immunomodulatory activity of Tinospora cordifolia may be attributed to the synergistic effect of group of compounds.
    In vivo:
    Indian J Pharmacol. 2013 May-Jun;45(3):237-43.
    Radioprotective and cytoprotective activity of Tinospora cordifolia stem enriched extract containing cordifolioside-A.[Pubmed: 23833365]
    The present study was undertaken to evaluate the radioprotective and cytoprotective potential of Cordifolioside A, a primary active constituent of n-butanol fraction of Tinospora Cordifolia (NBTC) against 4 Gy-γ radiation in mice and cyclophosphamide induced genotoxicity.
    METHODS AND RESULTS:
    Presence of Cordifolioside A in NBTC stem ethanolic extract was confirmed by high performance thin layer chromatography (HPTLC) analysis. Radioprotective activity was evaluated at 80 and 120 mg/kg, intraperitoneal (i.p.) dose of NBTC administered 15 days prior to whole body radiation exposure by observing survival rate, change in body weight, hematology, spleen colony forming unit (CFU), and micronucleus (MN) expression. Cytoprotective activity of NBTC was evaluated at 5, 10, and 15 mg/ml concentrations on Allium cepa root meristem growth against cyclophosphamide. HPTLC analysis of standard Cordifolioside A, and NBTC confirmed the presence of cordifolioside-A in NBTC with the retention factor value of 0.86. Administration of NBTC (120 mg/kg, i.p.) produced significant protection against radiation in terms of increased survival rate, body weight retention, hematological parameters, spleen CFU assay (P < 0.01), and decreased MN expression (P < 0.01). Cytoprotectivity was observed maximally at 10 mg/ml NBTC concentration with significant increase in root growth (P < 0.01), non-toxic mitotic index (MI) (65.9%) and lesser chromosomal aberrations (15.4%). NBTC at 10 mg/ml concentration showed very few C-anaphase compared to aberrations like fragmentation, C-anaphase, multipolarity and sticky chromosome in cyclophosphamide alone.
    CONCLUSIONS:
    The results suggest that enriched NBTC containing Cordifolioside A has a potential in vivo radioprotective effect as well as in vitro cytoprotective activity.
    Cordifolioside A Description
    Source: The herbs of Tinospora cordifolia
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9822 mL 9.9108 mL 19.8216 mL 39.6432 mL 49.554 mL
    5 mM 0.3964 mL 1.9822 mL 3.9643 mL 7.9286 mL 9.9108 mL
    10 mM 0.1982 mL 0.9911 mL 1.9822 mL 3.9643 mL 4.9554 mL
    50 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.7929 mL 0.9911 mL
    100 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.3964 mL 0.4955 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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