(-)-Isocorypalmine | CAS:483-34-1 | Manufacturer ChemFaces

(-)-Isocorypalmine

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Product Name	(-)-Isocorypalmine
Price:	$348 / 10mg
CAS No.:	483-34-1
Catalog No.:	CFN90582
Molecular Formula:	C₂₀H₂₃NO₄
Molecular Weight:	341.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The tubers of Corydalis yanhusuo W. T. Wang.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $131.5 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

(-)-Isocorypalmine has significant antifungal activity. l-isocorypalmine acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.

Targets:

cAMP | Antifection | Dopamine Receptor

In vitro:

FEBS Lett . 2014 Jan 3;588(1):198-204.

Cloning and characterization of canadine synthase involved in noscapine biosynthesis in opium poppy[Pubmed: 24316226]

Abstract Noscapine biosynthesis in opium poppy is thought to occur via N-methylcanadine, which would be produced through 9-O-methylation of (S)-scoulerine, methylenedioxy bridge formation on (S)-tetrahydrocolumbamine, and N-methylation of (S)-canadine. Only scoulerine 9-O-methyltransferase has been functionally characterized. We report the isolation and characterization of a cytochrome P450 (CYP719A21) from opium poppy that converts (S)-tetrahydrocolumbamine to (S)-canadine. Recombinant CYP719A21 displayed strict substrate specificity and high affinity (Km=4.63±0.71 μM) for (S)-tetrahydrocolumbamine. Virus-induced gene silencing of CYP719A21 caused a significant increase in (S)-tetrahydrocolumbamine accumulation and a corresponding decrease in the levels of putative downstream intermediates and noscapine in opium poppy plants. Keywords: BIA; Benzylisoquinoline alkaloid; CID; CPR; CYP; Cytochrome P450; ESI; GAPDH; LC–MS/MS; Methylenedioxy bridge; Noscapine biosynthesis; Papaver somniferum; SOMT; TNMT; TRV; VIGS; Virus-induced gene silencing; benzylisoquinoline alkaloid; collision-induced dissociation; cytochrome P450; cytochrome P450 reductase; electrospray ionization; glyceraldehyde 3-phosphate dehydrogenase; liquid chromatography–tandem mass spectrometry; scoulerine 9-O-methyltransferase; tetrahydroprotoberberine N-methyltransferase; tobacco rattle virus; virus-induced gene silencing.

In vivo:

Drug Alcohol Depen., 2013, 133(2):693- 703.

L-isocorypalmine reduces behavioral sensitization and rewarding effects of cocaine in mice by acting on dopamine receptors.[Pubmed: 24080315 ]

We previously reported isolation of l-isocorypalmine (l-ICP), a mono-demethylated analog of l-tetrahydropalmatine (l-THP), from the plant Corydalis yanhusuo. Here we characterized its in vitro pharmacological properties and examined its effects on cocaine-induced behaviors in mice.
METHODS AND RESULTS:
Receptor binding, cAMP and [(35)S]GTPγS assays were used to examine pharmacological actions of l-ICP in vitro. Effects of l-ICP on cocaine-induced locomotor hyperactivity and sensitization and conditioned place preference (CPP) in mice were investigated. HPLC was employed to analyze metabolites of l-ICP in mouse serum. Among more than 40 targets screened, l-ICP and l-THP bound only to dopamine (DA) receptors. l-ICP was a high-affinity partial agonist of D1 and D5 receptors and a moderate-affinity antagonist of D2, D3 and D4 receptors, whereas l-THP bound to only D1 and D5 receptors, with lower affinities than l-ICP. At 10mg/kg (i.p.), l-ICP inhibited spontaneous locomotor activity for a shorter time than l-THP. Pretreatment with l-ICP reduced cocaine-induced locomotor hyperactivities. Administration of l-ICP before cocaine once a day for 5 days reduced cocaine-induced locomotor sensitization on days 5 and 13 after 7 days of withdrawal. Pretreatment with l-ICP before cocaine daily for 6 days blocked cocaine-induced CPP, while l-ICP itself did not cause preference or aversion. HPLC analysis showed that l-ICP was the main compound in mouse serum following i.p. injection of l-ICP.
CONCLUSIONS:
l-ICP likely acts as a D1 partial agonist and a D2 antagonist to produce its in vivo effects and may be a promising agent for treatment of cocaine addiction.

(-)-Isocorypalmine Description

Source:	The tubers of Corydalis yanhusuo W. T. Wang.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antifungal Compound Library Anti-cocaine addiction Compound Library Antagonists Compound Library Activators Compound Library Alkaloids Compound Library Dopamine Receptor Inhibitor Library cAMP Inhibitor Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9291 mL	14.6456 mL	29.2912 mL	58.5823 mL	73.2279 mL
5 mM	0.5858 mL	2.9291 mL	5.8582 mL	11.7165 mL	14.6456 mL
10 mM	0.2929 mL	1.4646 mL	2.9291 mL	5.8582 mL	7.3228 mL
50 mM	0.0586 mL	0.2929 mL	0.5858 mL	1.1716 mL	1.4646 mL
100 mM	0.0293 mL	0.1465 mL	0.2929 mL	0.5858 mL	0.7323 mL

CFN95590	N-Methyltetrahydrocolumbamine	92758-34-4	356.4	C₂₁H₂₆NO₄+
CFN98384	Corydalmine	30413-84-4	341.4	C₂₀H₂₃NO₄
CFN98810	Canadine	5096-57-1	339.4	C₂₀H₂₁NO₄
CFN99195	Rotundine	10097-84-4	355.42	C₂₁H₂₅NO₄
CFN99553	Tetrahydropalmatine	2934-97-6	355.42	C₂₁H₂₅NO₄
CFN96484	Corynoxidine	57906-85-1	371.4	C₂₁H₂₅NO₅
CFN89271	Epicorynoxidine	58000-48-9	371.43	C₂₁H₂₅NO₅
CFN95204	N-Methylcorydalmine	81010-29-9	355.4	C₂₁H₂₅NO₄
CFN90188	D-Tetrahydropalmatine	3520-14-7	355.41	C₂₁H₂₅NO₄
CFN90416	Tetrahydrocoptisine	7461-02-1	323.12	C₁₉H₁₇NO₄