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    Natural Products
    Oroxin A
    Information
    CAS No. 57396-78-8 Price $178 / 20mg
    Catalog No.CFN99712Purity>=98%
    Molecular Weight432.38Type of CompoundFlavonoids
    FormulaC21H20O10Physical DescriptionYellow powder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $75.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Oroxin A

    Oroxin A
    Product Name Oroxin A
    CAS No.: 57396-78-8
    Catalog No.: CFN99712
    Molecular Formula: C21H20O10
    Molecular Weight: 432.38 g/mol
    Purity: >=98%
    Type of Compound: Flavonoids
    Physical Desc.: Yellow powder
    Targets: XO
    Source: The roots of Scutellaria baicalensis.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Price: $178 / 20mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
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  • J of Food Quality2020, 8851285.
  • Phytother Res.2016, 30(12):2020-2026
  • Molecules.2018, 23(7):E1817
  • Front Immunol.2018, 9:2655
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  • ACS Omega.2021, 6(36):23460-23474.
  • Nutrients.2018, 10(7)
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  • J Ethnopharmacol.2022, 282:114574.
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anticancer Compound Library
  • Inhibitors Compound Library
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  • Biological Activity
    Description: Oroxin A is a xanthine oxidase (XO) inhibitor, it exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress signaling pathway, and increasing key ER stress genes and expression levels.
    Targets: XO
    In vitro:
    Anticancer Drugs. 2016 Mar;27(3):204-15.
    Oroxin A inhibits breast cancer cell growth by inducing robust endoplasmic reticulum stress and senescence.[Pubmed: 26599214 ]
    Breast cancer is a major cause of cancer death among women. Although various anticancer drugs have been used in clinics, drugs that are effective against advanced and metastatic breast cancer are still lacking and in great demand.
    METHODS AND RESULTS:
    In this study, we found that Oroxin A, an active component isolated from the herb Oroxylum indicum (L.) Kurz, effectively inhibited the growth of human breast cancer cells MDA-MB-231 and MCF7 by inducing endoplasmic reticulum (ER) stress-mediated senescence. Oroxin A caused breast cancer cell cycle arrest at the G2/M stage, and reorganization of microtubules and actin cytoskeleton accompanied by a decrease in cellular mitosis. ER-specific probe ER-Tracker Red and confocal microscope imaging showed that ER-Tracker Red-positive cells increased in an Oroxin A dosage-dependent manner. In addition, Oroxin A increased cell population with high β-Gal activity and SAHF-positive staining; these data suggest that Oroxin A induces breast cancer cell ER stress and senescence. Mechanistic studies showed that Oroxin A led to a significant increase in intracellular reactive oxygen species levels, promoted expression of ER stress markers ATF4 and GRP78, and increased the phosphorylation of a key stress-response signaling protein p38, resulting in an ER stress-mediated senescence.
    CONCLUSIONS:
    Taken together, our data indicate that Oroxin A exerts its antibreast cancer effects by inducing ER stress-mediated senescence, activating the key stress p38 signaling pathway, and increasing key ER stress genes ATF4 and GRP78 expression levels.
    Oroxin A Description
    Source: The roots of Scutellaria baicalensis.
    Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3128 mL 11.5639 mL 23.1278 mL 46.2556 mL 57.8195 mL
    5 mM 0.4626 mL 2.3128 mL 4.6256 mL 9.2511 mL 11.5639 mL
    10 mM 0.2313 mL 1.1564 mL 2.3128 mL 4.6256 mL 5.782 mL
    50 mM 0.0463 mL 0.2313 mL 0.4626 mL 0.9251 mL 1.1564 mL
    100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4626 mL 0.5782 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Yao Xue Xue Bao. 2006 Apr;41(4):380-4.
    [Qualitative and quantitative determination of the main components of huanglianjiedu decoction by HPLC-UV/MS].[Pubmed: 16856488]
    To establish a comprehensive HPLC analytical method of Huanglianjiedu decoction.
    METHODS AND RESULTS:
    This study was performed by HPLC-UV/MS to identify the chemical constituents of the whole and individual herbs of the "Huanglianjiedu decoction". Zorbax Extend C18 (150 mm x 4. 6 mm ID, 5 microm) column was used; the mobile phase was composed of acetonitrile (A) and water (B, with 0.5% acetic acid) with gradient elution; the flow rate was 1.0 mL x min(-1) and the column temperature was setup at 25 degrees C. The detection wavelength was 254 nm. The chromatogram of Huanglianjiedu decoction showed 21 main peaks. Peaks 1, 2, 5 and 18 were from Gardenia jasminoides Ellis, Peaks 8, 13, 14, 15, 16, 17, 19 and 21 from Scutellaria baicalensis Georgi. While 10 from Coptis chinensis Franch and 20 from Phellodendron amurense Rupr., Peaks 3, 4, 6, 9, 11 and 12 came from them together. Peak 7 presented in the chromatograms of the herbs except Gardenia jasminoides Ellis. By comparison of the retention time, the on-line UV spectra and MS spectra, 11 peaks were identified as 5 (geniposide), 9 (jatrorrhizine), 10 (coptisine), 11 (palmatine), 12 (berberine), 13 (baicalin), 15 (Oroxin A), 17 (wogonoside), 19 (baicalein), 20 (obaculactone), 21 (wogonin), then eight of them were quantified by HPLC-UV.
    CONCLUSIONS:
    The method could represent the characteristics of Huanglianjiedu decoction, and it could be used to evaluate the quality and quantity of Huanglianjiedu decoction. It distinguished between Coptis chinensis Franch and Phellodendron amurense Rupr. by HPLC for the first time.
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