ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Orders via your E-mail:
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $365.7 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Korean Journal of Pharmacognosy...2014...Phytochemistry Letters2015, 243-247Appl Microbiol Biotechnol....2016...Molecules.2016, 21(6)Anal Bioanal Chem. 2016, 408(15)Int J Oncol.2016, 49(4):1497-504Braz J Med Biol Res. 2016, 49(7)Eur J Pharm Sci.2016, 94:33-45
Korean J. of Horticultural Sci. &...2017...Malaysian J of Fundamental and Ap...2018...Korean J of Medicinal Crop Scienc...2018...Biofactors.2018, 44(2):168-179Nutrients.2019, 11(11):E2694BMC Complement Altern Med....2019...Environ Toxicol.2019, 34(12):1354-1362Oxid Med Cell Longev2020, 12
Food Chem.2020, 313:126079Molecules.2020 ,25(16):3697.Advances in Traditional Medicine...2020...Oncol Lett.2020, 20(4):122.Int J Mol Sci.2020, 21(24):9369.Antioxidants (Basel).2020, 9(6):526.ACS Synth Biol.2020, 9(9):2282-2290.
Our products had been exported to the following research institutions and universities, And still growing.
Cornell University (USA)Kyung Hee University (Korea)University of Minnesota (USA)Mahatma Gandhi University (India)
Universidad de Antioquia (Colombia)Biotech R&D Institute (USA)Centralised Purchases Unit (CPU... (India)Colorado State University (USA)
University of Indonesia (Indonesia)Medical University of Gdansk (Poland)University of Bordeaux (France)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Biochem Biophys Res Commun.2020, 522(1):40-46Exp Parasitol.2015, 153:160-4Biofactors.2018, 44(2):168-179US20170000760 A12016, 42740Braz J Med Biol Res. 2016, 49(7)Molecules.2019, 24(24):E4536Food Chem.2019, 274:345-350Appl Microbiol Biotechnol.2016, 100(9):3965-77J Ethnopharmacol.2019, 235:406-414Food Chem.2019, 278:683-691
Related Screening Libraries
|Size /Price /Stock
||10 mM * 100 uL in DMSO / Inquiry / In-stock |
10 mM * 1 mL in DMSO / Inquiry / In-stock
||Triterpenoids Compound Library
||Isocucurbitacin D exhibited the highest activities of improved the LDL uptake rate.|
|J Nat Prod., 2020 Dec 24;83(12):3536-3544. |
|Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives[Pubmed: 33269591]|
|In the ongoing efforts to discover natural cholesterol-lowering compounds, dihydrocucurbitacin B, isolated from Trichosanthes cucumeroides roots, was found to promote LDL uptake by upregulating LDLR protein in a PCSK9-dependent process. In this study, an in-depth investigation of T. cucumeroides roots afforded 27 cucurbitacins (1-27), including seven new cucurbitacins (1-7), and their structures were elucidated by spectroscopic data analyses. In order to gain insight into their structure-activity relationship, cucurbitacin derivatives (B1-11 and DB1-11) were synthesized. Evaluation of lipid-lowering activities of these cucurbitacins by an LDL uptake assay in HepG2 cells revealed that most of the compounds improved the LDL uptake rate, among which hexanorIsocucurbitacin D (6) and Isocucurbitacin D (21) exhibited the highest activities (rates of 2.53 and 2.47, respectively), which were comparable to that of the positive control, nagilactone B (rate of 2.07). According to a mechanistic study by Western blot analysis, compounds 6 and 21 dose-dependently increased LDLR protein levels and reduced PCSK9 protein levels, representing promising new lipid-lowering drug candidates.|
Isocucurbitacin D Description
||The herbs of Trichosanthes cucumeroides
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.