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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $174.2 / In-stock||Other Packaging
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More articles cited ChemFaces products.
J Biol Chem.2014, 289(3):1723-31The Korea Society of Pha.2014, 300-314Plant Cell,Tissue & Organ Culture...2016...Int J Oncol.2016, 49(4):1497-504Sci Rep.2016, 6:25094Semyung University2017, 149407Aquaculture2017, 481:94-102Nat Chem Biol.2018, 14(8):760-763
BMC Pharmacol Toxicol.2018, 19(1):5Molecules.2018, 23(9):E2121Anal Bioanal Chem....2018...Biochem Biophys Res Commun....2018...Biochem Biophys Res Commun....2018...Front Pharmacol.2018, 9:236Journal of Life Science2018, 917-922Front Immunol. 2020, 11:62.
Int J Mol Sci.2020, 21(24):9369.Anal Bioanal Chem....2020...J Biosci.2020, 45:46.J of Pharmaceutical Analysis...2020...Biomed Chromatogr.2020, e5021.Food Research2021, 5(1):65-71Journal of Apicultural Research...2021...
Our products had been exported to the following research institutions and universities, And still growing.
Melbourne University (Australia)University of Indonesia (Indonesia)National Cancer Institute (USA)Nicolaus Copernicus Uniwersity (Poland)
CSIRO - Agriculture Flagship (Australia)Chang Gung University (Taiwan)Kyung Hee University (Korea)University of Beira Interior (Portugal)
Universiti Malaysia Pahang (Malaysia)University of Brasilia (Brazil)University of Padjajaran (Indonesia)
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1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Exp Mol Med.2020, 52(4):629-642.BMC Complement Altern Med.2018, 18(1):303Front Pharmacol.2020, 11:251.J Cancer.2019, 10(23):5843-5851J. of Med. Plant Research.2013, 90-151Nat Prod Sci.2019, 25(3):238Tropical J. of Pha. Research2017, 16(3):543-552Journal of Apicultural Research2021, 60(1)Acta Physiologiae Plantarum2015, 37:1736J Med Food.2016, 19(12):1155-1165
Related Screening Libraries
|| 3,3',4',5,6,7,8-Heptamethoxyflavone(HMF) has neuroprotective, chemopreventive, anti-allergic, anti-inflammatory, immunomodulatory, anti-aging and photoprotective effects; it inhibits collagenase activity and induces type I procollagen synthesis in HDFn cells, and against nitric oxide (NO) carcinogenesis.
||TNF-α | IL Receptor | gp120/CD4 | NO | MMP(e.g.TIMP) | MAPK | ERK | JNK | TGF-β/Smad|
|Int J Mol Sci. 2018 Feb 22;19(2). pii: E620. |
|3,5,6,7,8,3',4'-Heptamethoxyflavone, a Citrus Flavonoid, Inhibits Collagenase Activity and Induces Type I Procollagen Synthesis in HDFn Cells.[Pubmed: 29470423]|
|Citrus fruits contain various types of flavonoids with powerful anti-aging and photoprotective effects on the skin, and have thus been attracting attention as potential, efficacious skincare agents. |
METHODS AND RESULTS:
Here, we aimed to investigate the chemical composition of Citrus unshiu and its protective effects on photoaging. We isolated and identified a bioactive compound, 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), from C. unshiu peels using ethanol extraction and hexane fractionation. HMF inhibited collagenase activity and increased type I procollagen content in UV-induced human dermal fibroblast neonatal (HDFn) cells. HMF also suppressed the expression of matrix metalloproteinases 1 (MMP-1) and induced the expression of type I procollagen protein in UV-induced HDFn cells. Additionally, HMF inhibited ultraviolet B (UVB)-induced phosphorylation of the mitogen-activated protein kinases (MAPK) cascade signaling components-ERK, JNK, and c-Jun-which are involved in the induction of MMP-1 expression. Furthermore, HMF affected the TGF-β/Smad signaling pathway, which is involved in the regulation of type I procollagen expression. In particular, HMF induced Smad3 protein expression and suppressed Smad7 protein expression in UV-induced HDFn cells in a dose-dependent manner.
These findings suggest a role for Citrusunshiu in the preparation of skincare products in future.
|J Agric Food Chem. 2008 Oct 22;56(20):9399-403. |
|Anti-inflammatory activity of an orange peel polymethoxylated flavone, 3',4',3,5,6,7,8-heptamethoxyflavone, in the rat carrageenan/paw edema and mouse lipopolysaccharide-challenge assays.[Pubmed: 18816060 ]|
|The anti-inflammatory properties of 3',4',3,5,6,7,8-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), a citrus polymethoxylated flavone, were studied in the bacterial lipopolysaccharide (LPS)-challenge/tumor necrosis factor-alpha (TNFalpha) response in mice and in the carrageenan/paw edema assay in rats. |
METHODS AND RESULTS:
In each of these trials, HMF administered by intraperitoneal (ip) injection exhibited anti-inflammatory activity, whereas HMF administered orally (po) produced no effects. The inhibition observed in the LPS-challenge/TNFalpha assay correlated with the HMF levels in the blood sera of mice dosed (ip) with either 33 or 100 mg/kg body weight. Low levels of HMF (0.035 +/- 0.024 ppm) were detected in the blood sera of mice dosed orally [100 mg of HMF (suspended in vegetable oil)/kg], whereas ip injection led to higher levels (0.517 +/- 0.051 ppm). This may account for the different levels of anti-inflammatory effects observed in mice following ip vs oral HMF administration. HMF metabolites, including a number of mono- and di-demethylated HMF metabolites and their glucuronic acid conjugates, were also detected, but results of these studies suggest that the glucuronidated metabolites of HMF are inactive in these inflammation models.
|Cancer Lett. 2001 Feb 10;163(1):7-9. |
|Cancer chemopreventive activity of 3,5,6,7,8,3',4'-heptamethoxyflavone from the peel of citrus plants.[Pubmed: 11163102]|
METHODS AND RESULTS:
Nobiletin and 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HPT), isolated from the peel of Citrus plants, were examined for the anti-tumor-initiating activity on two-stage carcinogenesis of mouse skin tumors induced by a nitric oxide donor, (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexenamide, as an initiator and 12-O-tetradecanoylphorbol-13-acetate as a promoter.
HPT exhibited the remarkable anti-tumor-initiating effect on mouse skin and it suggested the possibility of HPT being a chemopreventive agent against nitric oxide (NO) carcinogenesis.
||The peels of Citrus nobilis Lour.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Neurochem Int. 2014 May;70:30-8. |
|3,5,6,7,8,3',4'-Heptamethoxyflavone, a citrus flavonoid, on protection against memory impairment and neuronal cell death in a global cerebral ischemia mouse model.[Pubmed: 24657445 ]|
METHODS AND RESULTS:
The present study evaluated the effects of treatment with the citrus flavonoid, 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF) on protection against memory impairment and neuronal death in a global cerebral ischemia mouse model. The results showed that HMF, administrated for three days immediately after ischemic surgery, protected against ischemia-induced memory dysfunction, rescued neuronal cell death in the CA1 cell layer, increased the production of BDNF, stimulated the autophosphorylation of CaMK II and suppressed microglial activation in the hippocampus.
These results suggest that HMF has a neuroprotective effect after brain ischemia by inducing BDNF production and anti-inflammatory effects.
|Biomed Res. 2016;37(2):95-9. |
|3,5,6,7,8,3',4'-Heptamethoxyflavone reduces interleukin-4 production in the spleen cells of mice.[Pubmed: 27108879 ]|
|In our previous studies, we reported anti-inflammatory functions of 3,5,6,7,8,3',4'-heptamethoxyflavone (3,3',4',5,6,7,8-heptamethoxyflavone ,HMF), which is a polymethoxyflavone rich in various citrus fruits. |
METHODS AND RESULTS:
Here, we investigated the immunomodulatory function of HMF in mice. HMF administration (50 mg/kg, i.p., 2 times/week) tended to reduce the production of antigen-specific IgE induced by ovalbumin in combination with aluminum hydroxide gel. Fluorescence-activated cell sorting analysis revealed the reduction of interleukin-4(+)CD4(+) spleen cells and sustained presence of interferon-γ(+)CD4(+) spleen cells in mice administered HMF, whereas the ratio of CD4(+)CD8(-) versus CD4(-)CD8(+) spleen cells was not affected. Interleukin-4 release from CD3/CD28-stimulated spleen cells of mice administered HMF was reduced, whereas interferon-γ release was not affected.
These results suggest that HMF has an immunomodulatory function via reduced interleukin-4 expression.