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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $365.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Chem Biol Interact.2018, 283:59-74Plant Physiol Biochem.2019, 144:355-364Biomedicines.2021, 9(8):954.Molecules.2022, 27(21):7643. Biotechnol Bioeng....2020...J Cell Mol Med.2022, 26(23):5807-5819.Vietnam J. Chemistry2022, 60(2):211-222J Breast Cancer.2015, 18(2):112-118
Molecules.2018, 23(12):E3103Korean j.of Pharm.2017, 70-76Phytother Res.2022, 10.1002:ptr.7602.Eur Endod J.2020, 5(1):23-27.J Traditional Thai Medical Res....2022...J Korean Society of Food Science ...2021...Huazhong Agricultural University...2022...Int J Mol Sci.2020, 21(9):3239.
Food Bioscience2022, 50:102187.Evid Based Complement Alternat Me...2017...Nutrients.2018, 10(7)World J Mens Health.2019, 10.5534Phytother Res.2019, 33(4):1104-1113Molecules.2022, 27(5):1675Plants2022, 11(3),294.
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Our products had been exported to the following research institutions and universities, And still growing.
Helmholtz Zentrum München (Germany)Calcutta University (India)University of Fribourg (Switzerland)University of Vienna (Austria)
Kazusa DNA Research Institute (Japan)Institute of Chinese Materia Me... (China)Korea Intitute of Science and T... (Korea)University of Illinois at Chicago (USA)
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Isophysalin A
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manager@chemfaces.com
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+86-27-84254680
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LWT-Food Sci Technol2020, 109163JPC-Journal of Planar Chromatography 2017, 30(2)Chem Pharm Bull (Tokyo).2019, 67(11):1242-1247Plants (Basel).2021, 10(2):278. Environ Toxicol.2021, doi: 10.1002J Nat Prod.2018, 81(4):966-975Agriculture2022, 12(2),227.Allergol Immunopathol (Madr).2022, 1;50(4):23-30.PLoS One.2022, 17(6):e0268505. Appl. Sci.2020, 10(20),7374.
Related Screening Libraries
Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
|
Description: |
Isophysalin A exhibits anti-inflammatory activitiy, it exhibits conjugating abilities with glutathione and also shows significant nitric oxide (NO) production inhibiting activities. |
Targets: |
NO | IkB | IKK |
Isophysalin A Description
Source: |
The herbs of Physalis alkekengi |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
1.8993 mL |
9.4967 mL |
18.9934 mL |
37.9867 mL |
47.4834 mL |
5 mM |
0.3799 mL |
1.8993 mL |
3.7987 mL |
7.5973 mL |
9.4967 mL |
10 mM |
0.1899 mL |
0.9497 mL |
1.8993 mL |
3.7987 mL |
4.7483 mL |
50 mM |
0.038 mL |
0.1899 mL |
0.3799 mL |
0.7597 mL |
0.9497 mL |
100 mM |
0.019 mL |
0.095 mL |
0.1899 mL |
0.3799 mL |
0.4748 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Kinase Assay: |
Steroids. 2012 Apr;77(5):441-7. | Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors.[Pubmed: 22197662] | Michael reaction acceptors (MRAs) are a class of active molecules that are directly or indirectly involved in various cellular processes, including the regulation of many signaling pathways. METHODS AND RESULTS: In this study, the inducible nitric oxide synthase (iNOS) assay was used to demonstrate that the dichloromethane extract of Physalis alkekengi var. franchetii (DCEP) possesses anti-inflammatory activity that might be attributed to the modification of key cysteine residues in IKKβ by the MRAs in DCEP. To isolate these MRAs, glutathione (GSH) was employed, and a simple ultra-performance liquid chromatography/tandem mass spectrometry (UPLC-MS/MS) screening method was developed to investigate the GSH conjugates with potential MRAs. Five physalins, including one new compound Isophysalin A (2), together with four known steroidal compounds, physalin A (1), physalin O (3), physalin L (4) and physalin G (5), were isolated to evaluate the GSH conjugating abilities, and it was indicated that compounds 1, 2 and 3, which had a common α,β-unsaturated ketone moiety, exhibited conjugating abilities with GSH and also showed significant nitric oxide (NO) production inhibiting activities.
CONCLUSIONS:
The anti-inflammatory activities of compounds 1, 2 and 3 might be attributed to their targeting multiple cysteine residues on IKKβ; therefore, the alkylation of IKKβ by compound 1 was further studied by micrOTOF-MS. The result showed that six cysteine residues (C(59), C(179), C(299), C(370), C(412), and C(618)) were alkylated, which indicated that IKKβ is a potential target for the anti-inflammatory activity of physalin A. |
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