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    Natural Products
    Kadsuracoccinic acid A
    Kadsuracoccinic acid A
    Information
    CAS No. 1016260-22-2 Price
    Catalog No.CFN99029Purity>=98%
    Molecular Weight468.7 Type of CompoundTriterpenoids
    FormulaC30H44O4Physical DescriptionPowder
    Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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    Kadsuracoccinic acid A

    Kadsuracoccinic acid A
    Product Name Kadsuracoccinic acid A
    CAS No.: 1016260-22-2
    Catalog No.: CFN99029
    Molecular Formula: C30H44O4
    Molecular Weight: 468.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Source: The herbs of Kadsura coccinea
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
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  • J Ethnopharmacol.2017, 198:91-97
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  • Biological Activity
    Description: Kadsuracoccinic acid A has anticancer activity, it induces significant cleavage arrest. Kadsuracoccinic acid A may be related to the preservation of the progression of the M phase.
    Kadsuracoccinic acid A Description
    Source: The herbs of Kadsura coccinea
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1336 mL 10.6678 mL 21.3356 mL 42.6712 mL 53.339 mL
    5 mM 0.4267 mL 2.1336 mL 4.2671 mL 8.5342 mL 10.6678 mL
    10 mM 0.2134 mL 1.0668 mL 2.1336 mL 4.2671 mL 5.3339 mL
    50 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8534 mL 1.0668 mL
    100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4267 mL 0.5334 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    J Nat Prod. 2008 Apr;71(4):739-41.
    Kadsuracoccinic acids A-C, ring-A seco-lanostane triterpenes from Kadsura coccinea and their effects on embryonic cell division of Xenopus laevis.[Pubmed: 18271558]

    METHODS AND RESULTS:
    Three new 3,4- seco-lanostanes, Kadsuracoccinic acid A - C ( 1- 3), were isolated from the medicinal plant Kadsura coccinea, in addition to the known compounds kadsuric acid ( 4) and micranoic acid A ( 5). The structures of 1- 3 were elucidated by analysis of their 2D-NMR spectroscopic data. Furthermore, the relative conformation of 1 was confirmed by an X-ray crystallographic study.
    CONCLUSIONS:
    This is the first report of a 3,4- seco-lanostane-type triterpene with a 17(20)-ene functional group. Treatment of cultured individual Xenopus laevis cells with 1 at the blastular stage arrested cleavage of these cells with an IC 50 of 0.32 microg/mL.
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