Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Lanosterol
    Lanosterol
    Information
    CAS No. 79-63-0 Price $288 / 10mg
    Catalog No.CFN92368Purity>=98%
    Molecular Weight426.7Type of CompoundTriterpenoids
    FormulaC30H50OPhysical DescriptionPowder
    Download Manual    COA    MSDS    SDFSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $187.2 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Washington State University (USA)
  • Universidade de Franca (Brazil)
  • Universiti Putra Malaysia(UPM) (Malaysia)
  • Aveiro University (Portugal)
  • Tohoku University (Japan)
  • Wroclaw Medical University (Poland)
  • Sanford Burnham Medical Researc... (USA)
  • Kyoto University (Japan)
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Hertfordshire (United Kingdom)
  • Technical University of Denmark (Denmark)
  • More...
  • Package
    Featured Products
    Moracin M

    Catalog No: CFN92327
    CAS No: 56317-21-6
    Price: $318/5mg
    Isochlorogenic acid B

    Catalog No: CFN99119
    CAS No: 14534-61-3
    Price: $70/20mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    Terrestrosin K

    Catalog No: CFN90822
    CAS No: 193605-07-1
    Price: $218/10mg
    Dictamnine

    Catalog No: CFN99783
    CAS No: 484-29-7
    Price: $100/20mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg

    Lanosterol

    Lanosterol
    Product Name Lanosterol
    CAS No.: 79-63-0
    Catalog No.: CFN92368
    Molecular Formula: C30H50O
    Molecular Weight: 426.7 g/mol
    Purity: >=98%
    Type of Compound: Triterpenoids
    Physical Desc.: Powder
    Targets: Dopamine Receptor | Autophagy
    Source: The herbs of Portulaca oleracea L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $288 / 10mg
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • The Korea Journal of Herbology2016, 29-35
  • J Mater Chem B.2019, 7(39):5896-5919
  • iScience.2020, 23(2):100849.
  • The Malaysian journal of pathology2019, 41(3):243-251
  • Analytical sci. & Tech2016, 186-193
  • BioResources J.2020, 15(3).
  • Eur Endod J.2020, 5(1):23-27.
  • J Chromatogr Sci.2020, 58(6):485-493.
  • J Pharmaceut Biomed2020, 178:112894
  • SBRAS2016, 12
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Cancer chemoprevention Compound Library
  • Precursors Compound Library
  • Anti-cataract Compound Library
  • Triterpenoids Compound Library
  • Dopamine Receptor Inhibitor Library
  • Autophagy Inhibitor Library
  • Biological Activity
    Description: Lanosterol is a key triterpenoid intermediate in the biosynthesis of Cholesterol. Lanosterol induces mild depolarization of mitochondria and promotes autophagy, it is indicative of altered Lanosterol metabolism during PD pathogenesis. 10 μM Lanosterol during IVM in medium without serum and bases on recombinant human chorionic gonadotrophin has a positive effect on maturation of prepubertal ewe oocytes.
    Targets: Dopamine Receptor | Autophagy
    In vitro:
    Zygote. 2014 Feb;22(1):50-7.
    Effect of lanosterol on the in vitro maturation in semi-defined culture system of prepubertal ewe oocytes.[Pubmed: 21838962]
    The choice of medium and supplements can affect meiotic regulation and may have an impact on the regulation of mammalian oocyte growth and embryonic cell function. The aim of the present study was to assess the effects of oxygen concentration and endogenous Lanosterol on the in vitro maturation (IVM) media without serum and based on recombinant human chorionic gonadotrophin in prepubertal ewe oocytes.
    METHODS AND RESULTS:
    Firstly, the effect of varying oxygen concentrations (5% and 20%) during IVM in TCM-199 supplemented (4 mg/ml bovine serum albumin (BSA), 100 μM cysteamine, 0.3 mM sodium pyruvate, 0.1 UI/ml recombinant follicle-stimulating hormone (r-FSH; Gonal-F® 75 UI, Serono, Italy), 0.1 UI/ml recombinant leuteinizing hormone (r-LH; Lhadi® 75 UI, Serono, Italy) and 1 μg/ml estradiol-17β) on subsequent nuclear maturation of oocytes examined under ultraviolet light following staining with bisbenzimide (Hoechst 33342) was investigated. Secondly, two concentrations of Lanosterol (0, 10 and 50 μM) were added to the IVM medium. Nuclear maturation of oocytes was examined as previously. Lipid content in oocytes, an important indicator of cytoplasmic maturity, was also measured using Nile red fluorescent stain. The results showed that low oxygen concentration affected the nuclear maturation. Similarly, a significantly higher rate of meiosis resumption was observed with 10 μM (72.3%) of Lanosterol compared with the control (51.8%) or 50 μM of Lanosterol (59.4%). A significantly higher content of lipids was also observed with 10 and 50 μM of Lanosterol (7.3 ± 0.2 × 10(6) and 7.4 ± 0.2 × 10(6) arbitrary units of fluorescence) compared with the control (6.7 ± 0.2 × 10(6) arbitrary units of fluorescence).
    CONCLUSIONS:
    The results indicate that 10 μM Lanosterol during IVM in medium without serum and based on recombinant human chorionic gonadotrophin has a positive effect on maturation of prepubertal ewe oocytes.
    Cell Death Differ. 2012 Mar;19(3):416-27.
    Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.[Pubmed: 21818119]
    To investigate the anti-HBV constituents in the roots of Euphorbia fischeriana.
    METHODS AND RESULTS:
    The compounds were isolated by various chromatographic methods and identified by spectroscopic analysis. Some compounds were tested for the anti-HBV activity. Eleven compounds were isolated and identified as tirucalla-5,24-dien-3-ol (1), 24-methyltirucalla-5, 24-dien-3-ol (2), euphol (3), Butyrospermol (4), 24-methylenecycloartenol (5), cycloartenol (6), jolkinolid E (7) helioscopinolide A (8), isoscopoletion (9), dephnoretin (10), and 3, 3'-di-O-methylellagic acid 4'-O-beta-D-xylopyranoside (11).
    CONCLUSIONS:
    Compounds 1, 2 and 10 were isolated from the genus Euphorbia for the first time. Compounds 3, 4 and 11 were isolated from this species for the first time. Compounds 1, 8, 9 and 11 showed weak anti-HBsAg and anti-HBeAg activity, while compound 10 showed weak anti-HBsAg activity.
    Lanosterol Description
    Source: The herbs of Portulaca oleracea L.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Pieceid-2''-O-gallate

    Catalog No: CFN95226
    CAS No: 105304-51-6
    Price: $318/10mg
    Bergaptol-beta-glucopyranoside

    Catalog No: CFN95186
    CAS No: 131623-13-7
    Price: $318/10mg
    Isoliquiritin

    Catalog No: CFN99155
    CAS No: 5041-81-6
    Price: $138/20mg
    Picrasidine Q

    Catalog No: CFN92205
    CAS No: 101219-61-8
    Price: $388/10mg
    Patulitrin

    Catalog No: CFN95153
    CAS No: 19833-25-1
    Price: $398/5mg
    Scutellarein-7-O-glucoside

    Catalog No: CFN95082
    CAS No: 26046-94-6
    Price: $318/5mg
    Astin B

    Catalog No: CFN95188
    CAS No: 151201-76-2
    Price: $318/10mg
    Methylenetanshinquinone

    Catalog No: CFN92179
    CAS No: 67656-29-5
    Price: $338/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.3436 mL 11.7178 mL 23.4357 mL 46.8713 mL 58.5892 mL
    5 mM 0.4687 mL 2.3436 mL 4.6871 mL 9.3743 mL 11.7178 mL
    10 mM 0.2344 mL 1.1718 mL 2.3436 mL 4.6871 mL 5.8589 mL
    50 mM 0.0469 mL 0.2344 mL 0.4687 mL 0.9374 mL 1.1718 mL
    100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.4687 mL 0.5859 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Moracin M

    Catalog No: CFN92327
    CAS No: 56317-21-6
    Price: $318/5mg
    Isochlorogenic acid B

    Catalog No: CFN99119
    CAS No: 14534-61-3
    Price: $70/20mg
    Ginsenoside Compound K

    Catalog No: CFN99756
    CAS No: 39262-14-1
    Price: $100/20mg
    Chrysin 6-C-arabinoside 8-C-glucos...

    Catalog No: CFN92284
    CAS No: 185145-33-9
    Price: $368/5mg
    Terrestrosin K

    Catalog No: CFN90822
    CAS No: 193605-07-1
    Price: $218/10mg
    Dictamnine

    Catalog No: CFN99783
    CAS No: 484-29-7
    Price: $100/20mg
    Glycitin

    Catalog No: CFN99105
    CAS No: 40246-10-4
    Price: $70/20mg