Catechin 7-O-beta-D-glucopyranoside | CAS:65597-47-9

Catechin 7-O-beta-D-glucopyranoside

Citing Use of our Products

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal & Western Union

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $206.7 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Featured Products

Oroxylin A 7-O-beta-D-glucuronide

Catalog No: CFN90191
CAS No: 36948-76-2
Price: $318/20mg

3-Oxosapriparaquinone

Catalog No: CFN92176
CAS No: 119139-56-9
Price: $/mg

Tangeretin

Catalog No: CFN90240
CAS No: 481-53-8
Price: $30/20mg

8,8''-Bibaicalein

Catalog No: CFN95007
CAS No: 135309-02-3
Price: $318/5mg

Syringaresinol-di-O-glucoside

Catalog No: CFN90458
CAS No: 66791-77-3
Price: $188/20mg

Mulberroside A

Catalog No: CFN99586
CAS No: 102841-42-9
Price: $60/20mg

Enmein

Catalog No: CFN92435
CAS No: 3776-39-4
Price: $433/5mg

Description:

Catechin 7-O-beta-D-glucopyranoside has intestinal anti-inflammatory activity. Catechin 7-O-beta-D-glucopyranoside has a protective effect against STZ-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction.Catechin 7-O-β-D-glucopyranoside has strong inhibitory activity against α-amylase and α-glucosidase.Catechin 7-O-β-D-glucopyranoside has the activity of inhibiting protein glycation.

In vitro:

Cell Biochem Funct . 2010 Dec 2;28(8):651-660.

Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells[Pubmed: 21104932]

The protective effects of catechin 7-O-β-D glucopyranoside (C7G) against streptozotocin (STZ)-induced mitochondrial damage in rat pancreatic β-cells (RINm5F) were investigated. A marked increase in mitochondrial reactive oxygen species (ROS) was observed in STZ-treated cells; this increase was restricted by C7G treatment. C7G also scavenged superoxide anions and hydroxyl radicals generated by xanthine/xanthine oxidase (xanthine/XO) and the Fenton reaction (FeSO(4) + H(2) O(2)), respectively. C7G restored activity and expression of both mitochondrial manganese superoxide dismutase (MnSOD) and catalase (CAT), which were suppressed by STZ treatment. In addition, C7G prevented STZ-induced mitochondrial lipid peroxidation, protein carbonyl, and DNA base modification. C7G restored the loss of mitochondrial membrane potential (Δψ) that was disrupted by STZ treatment, and prevented cell death via inhibition of apoptosis. These results suggest that C7G has a protective effect against STZ-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction.

J Food Sci . 2019 Nov;84(11):3172-3178.

Isolation and Characterization of Antihyperglycemic Compounds from Vigna angularis Extracts[Pubmed: 31613007]

Functional foods that inhibit α-amylase and α-glucosidase activity are effective for regulating the blood glucose level and preventing hyperglycemia. Extracts of adzuki beans (ABs, Vigna angularis), widely eaten in East Asia, can inhibit α-amylase and α-glucosidase activity. In this study, we identified and evaluated the components in an AB water extract (ABWE) after boiling, which is an essential process for cooking ABs. The ABWE before boiling inhibited α-amylase and α-glucosidase activity and the boiled ABWE showed slightly stronger inhibitory effects. High-performance liquid chromatography, liquid chromatography-mass spectrometry, and nuclear magnetic resonance analyses identified (+)-catechin 7-O-β-d-glucopyranoside (C7G), (+)-epicatechin 7-O-β-d-glucopyranoside (E7G), and (+)-catechin as the bioactive components in boiled ABWE. Interestingly, the quantity of E7G significantly increased after boiling (from 0% to 17.1 ± 1.3%). E7G showed stronger inhibition of α-amylase and α-glucosidase than C7G; the IC50 values for α-amylase were 0.74 ± 0.04 mg/mL (C7G) and 0.40 ± 0.09 mg/mL (E7G), and for α-glucosidase the IC50 values were 0.085 ± 0.032 mg/mL (C7G) and 0.051 ± 0.007 mg/mL (E7G). Our findings suggest that C7G and E7G are the main active components in ABWE as they inhibit α-amylase and α-glucosidase and their inhibitory effect is not lost after boiling. These results support the effectiveness of boiled ABs in the promotion of health. PRACTICAL APPLICATION: We identified (+)-catechin 7-O-β-d-glucopyranoside (C7G), (+)-epicatechin 7-O-β-d-glucopyranoside (E7G), and (+)-catechin in adzuki bean extracts and commercially available boiled adzuki bean products. Interestingly, the E7G content was increased by boiling, and this compound showed strong inhibitory activity toward α-amylase and α-glucosidase. These results support the consumption of boiled adzuki beans to prevent acute rises in blood glucose level.

Planta Med . 2008 Dec;74(15):1800-1802.

Flavan-3-ols from Ulmus davidiana var. japonica with inhibitory activity on protein glycation[Pubmed: 18991204]

Four flavan-3-ols, (+)-catechin ( 1), (+)-catechin 7- O- beta- D-apiofuranoside ( 2), (+)-catechin 7- O- beta- D-xylopyranoside ( 3), (+)-catechin 7- O- beta- D-glucopyranoside ( 4), and proanthocyanidin A-1 ( 5) as well as three other constituents, isolated from an EtOAc-soluble extract of the stem barks of Ulmus davidiana var. japonica, were evaluated for inhibitory activity against the formation of AGEs. Compounds 1 - 5 exhibited a significant inhibitory activity on the formation of AGEs in an AGEs-BSA assay by specific fluorescence and this was confirmed by an indirect AGEs-ELISA. Moreover, compounds 1 and 5 markedly reduced AGEs-BSA cross-linking to collagen in a dose-dependent manner. AGEs:advanced glycation end products BSA:bovine serum albumin CC:column chromatography CD:circular dichroism.

In vivo:

Int Immunopharmacol . 2015 Dec;29(2):521-527.

Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats[Pubmed: 26453508]

The seeds of Phaseolus calcaratus Roxburgh (PHCR) are common legumes that comprise part of the daily diet in Chinese and Korean culture. Recent findings highlight anti-inflammatory and anti-septic potentials of catechin-7-O-β-D-glucopyranoside (CGP) isolated from PHCR seeds. We investigated the intestinal anti-inflammatory activity and associated mechanisms of CGP using a rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis. Oral treatment with CGP (10mg/kg body weight) suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. This treatment reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats. CGP treatment also inhibited the TNBS-mediated increases in nitric oxide synthase, cyclooxygenase-2, interleukin-1β, tumor necrosis factor-α, intercellular adhesion molecule-1, and monocyte chemotactic protein-1 proteins or mRNA levels. This inhibition was accompanied by the increased mRNA levels of mucins MUC2 and MUC3. The CGP treatment prevented phosphorylation of p38 mitogen-activated protein kinase, IκB-α, and DNA-nuclear factor-κB binding, all of which were increased in the inflamed colons of TNBS-treated rats. Furthermore, oral administration with a crude PHCR butanol extract (100mg/kg body weight) which contains 1.5% of CGP showed intestinal anti-inflammatory potentials similar to that of CGP. Collectively, our current findings suggest that CGP or CGP-containing PHCR seeds may have favorable effects on intestinal inflammatory diseases.

Animal Research:

Arch Pharm Res . 2011 Sep;34(9):1443-1450.

Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica[Pubmed: 21975805]

In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B(3) (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.

Structure Identification:

J Food Sci . 2019 Nov;84(11):3172-3178.

Isolation and Characterization of Antihyperglycemic Compounds from Vigna angularis Extracts[Pubmed: 31613007]

CAS No.	65597-47-9	Price	$318 / 10mg
Catalog No.	CFN95524	Purity	>95%
Molecular Weight	452.4	Type of Compound	Flavonoids
Formula	C₂₁H₂₄O₁₁	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Catechin 7-O-beta-D-glucopyranoside
CAS No.:	65597-47-9
Catalog No.:	CFN95524
Molecular Formula:	C₂₁H₂₄O₁₁
Molecular Weight:	452.4 g/mol
Purity:	>95%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Spiraea hypericifolia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:	$318 / 10mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

Source:	The herbs of Spiraea hypericifolia L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2104 mL	11.0522 mL	22.1043 mL	44.2087 mL	55.2608 mL
5 mM	0.4421 mL	2.2104 mL	4.4209 mL	8.8417 mL	11.0522 mL
10 mM	0.221 mL	1.1052 mL	2.2104 mL	4.4209 mL	5.5261 mL
50 mM	0.0442 mL	0.221 mL	0.4421 mL	0.8842 mL	1.1052 mL
100 mM	0.0221 mL	0.1105 mL	0.221 mL	0.4421 mL	0.5526 mL

CFN95552	Symplocoside	76502-76-6	466.4	C₂₂H₂₆O₁₁
CFN99052	Catechin 3-rhamnoside	103630-03-1	436.4	C₂₁H₂₄O₁₀
CFN92987	3,4-O,O-Methylene-(+)-catechin	89329-14-6	302.28	C₁₆H₁₄O₆
CFN92954	5,7,4'-Trimethoxyafzelechin	918428-88-3	316.35	C₁₈H₂₀O₅
CFN96042	5,7,4'-Tri-O-methylcatechin	105330-59-4	332.4	C₁₈H₂₀O₆
CFN99138	(+)-Gallocatechin	970-73-0	306.27	C₁₅H₁₄O₇
CFN89499	Afzelechin 3-O-xyloside	512781-45-2	406.38	C₂₀H₂₂O₉
CFN98617	3,4,4',7-Tetrahydroxyflavan	38412-82-7	274.3	C₁₅H₁₄O₅
CFN99646	Catechin	154-23-4	290.3	C₁₅H₁₄O₆
CFN99568	(+)-Catechin hydrate	7295-85-4	308.28	C₁₅H₁₄O₆.H₂O