Laurolitsine | CAS:5890-18-6 | Manufacturer ChemFaces

Laurolitsine

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Laurolitsine Description

Source:	The roots of Lindera aggregata (Sims) Kosterm
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 2013 Mar 22;76(3):405-12.

Semisynthesis and myocardial activity of thaliporphine N-homologues.[Pubmed: 23305495]

The N-homologues and optical isomers of thaliporphine (5a), a potent antiarrhythmic agent, were prepared starting from Laurolitsine (1), an abundant aporphine present in Phoebe formosana.
METHODS AND RESULTS:
Treating N-propylnorglaucine with 90% H2SO4 yielded one additional product, an 11-sulfonyl-1,11-anhydroaporphine. Reaction of N-formylnorglaucine (3a) with 90% H2SO4, however, yielded the 9-sulfonyl-seco product as a major product. Treatment of 3a with 98% H2SO4 yielded pancordine (10), which, upon catalytic hydrogenation, yielded (±)-wilsonirine. (1)H NMR spectroscopic analysis was applied successfully to monitor the optical purity of the crystalline salt while undertaking optical resolution.
CONCLUSIONS:
Thaliporphine (5a) was demonstrated to possess better positive inotropic and less negative chronotropic effects than the left-hand optical isomer and showed the best activity on rat cardiac tissue among the N-homologues prepared.

Product Name	Laurolitsine
Price:
CAS No.:	5890-18-6
Catalog No.:	CFN90492
Molecular Formula:	C₁₈H₁₉NO₄
Molecular Weight:	313.34 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Cryst.
Source:	The roots of Lindera aggregata (Sims) Kosterm
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1914 mL	15.9571 mL	31.9142 mL	63.8284 mL	79.7855 mL
5 mM	0.6383 mL	3.1914 mL	6.3828 mL	12.7657 mL	15.9571 mL
10 mM	0.3191 mL	1.5957 mL	3.1914 mL	6.3828 mL	7.9786 mL
50 mM	0.0638 mL	0.3191 mL	0.6383 mL	1.2766 mL	1.5957 mL
100 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.6383 mL	0.7979 mL

CFN91018	(-)-Anonaine	1862-41-5	265.31	C₁₇H₁₅NO₂
CFN91019	Roemerine	548-08-3	279.33	C₁₈H₁₇NO₂
CFN91767	Fissistigine A	70420-58-5	311.33	C₁₈H₁₇NO₄
CFN93031	Laetanine	72361-67-2	313.35	C₁₈H₁₉NO₄
CFN90492	Laurolitsine	5890-18-6	313.34	C₁₈H₁₉NO₄
CFN99528	Norisoboldine	23599-69-1	313.35	C₁₈H₁₉NO₄
CFN96271	Norglaucine hydrochloride	39945-41-0	377.9	C₂₀H₂₄ClNO₄
CFN96155	Dehydroformouregine	107633-69-2	337.4	C₂₀H₁₉NO₄
CFN89485	6-Formyl-1,2,9,10-tetramethoxy-6a,7-dehydroaporphine	2101836-45-5	367.39	C₂₁H₂₁NO₅
CFN97889	Cassyfiline	4030-51-7	341.4	C₁₉H₁₉NO₅