Leucodin | CAS:17946-87-1 | Manufacturer ChemFaces

Leucodin

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Description:

Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM.

Targets:

TNF-α | MMP(e.g.TIMP)

In vitro:

Molecules. 2016 Mar 25;21(4):404.

The Chemical Composition of Achillea wilhelmsii C. Koch and Its Desirable Effects on Hyperglycemia, Inflammatory Mediators and Hypercholesterolemia as Risk Factors for Cardiometabolic Disease.[Pubmed: 27023504 ]

METHODS AND RESULTS:
The chloroform fraction (CF) and ethyl acetate fraction (EAF) both showed a significant ability to reduce the secretion of tumor necrosis factor alpha (TNF-α). The EAF, however, also attenuated the levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9). The CF showed the most significant 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) inhibition activity. The five main compounds in the CF were isolated and identified.
CONCLUSIONS:
Out of the five compounds in the CF, 1β,10β-epoxydesacetoxymatricarin (CP1) and Leucodin (CP2) showed the highest anti-hypercholesterolemic potential. A molecular docking study provided corresponding results.

Planta Med. 1998 Aug;64(6):577-8.

Desacetylmatricarin, an anti-allergic component from Taraxacum platycarpum.[Pubmed: 9741305]

METHODS AND RESULTS:
The bioassay-guided fractionation of Taraxacum platycarpum (Compositae) extract led to the isolation of a desacetylmatricarin (1) as an active principle responsible for the anti-allergic property.
CONCLUSIONS:
It showed a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 was 7.5 microM. Two structurally related guaianolide sesquiterpenes, achillin and Leucodin, were also examined and their IC50 values were determined as 100 microM and 80 microM, respectively.

Leucodin Description

Source:	The roots of Scorzonera latifolia (Fisch. and Mey.) DC.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Leucodin
Price:
CAS No.:	17946-87-1
Catalog No.:	CFN96803
Molecular Formula:	C₁₅H₁₈O₃
Molecular Weight:	246.30 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Scorzonera latifolia (Fisch. and Mey.) DC.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-hyperlipidemic Compound Library Anti-allergy Compound Library Sesquiterpenoids Compound Library TNF-α Inhibitor Library MMP(e.g.TIMP) Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0601 mL	20.3004 mL	40.6009 mL	81.2018 mL	101.5022 mL
5 mM	0.812 mL	4.0601 mL	8.1202 mL	16.2404 mL	20.3004 mL
10 mM	0.406 mL	2.03 mL	4.0601 mL	8.1202 mL	10.1502 mL
50 mM	0.0812 mL	0.406 mL	0.812 mL	1.624 mL	2.03 mL
100 mM	0.0406 mL	0.203 mL	0.406 mL	0.812 mL	1.015 mL

CFN96803	Leucodin	17946-87-1	246.30	C₁₅H₁₈O₃
CFN96955	Desacetylmatricarin	10180-88-8	262.30	C₁₅H₁₈O₄
CFN89005	1beta,10beta-Epoxydesacetoxymatricarin	124020-39-9	262.30	C₁₅H₁₈O₄
CFN95434	Jacquilenin	7726-34-3	262.3	C₁₅H₁₈O₄
CFN95432	Crepidiaside B	101921-35-1	424.5	C₂₁H₂₈O₉
CFN95433	11beta,13-Dihydrolactucin	83117-63-9	278.3	C₁₅H₁₈O₅
CFN89190	Artemyriantholide D	421558-76-1	492.61	C₃₀H₃₆O₆
CFN98720	Dehydrocostus lactone	477-43-0	230.3	C₁₅H₁₈O₂
CFN99030	Sulfocostunolide A	1016983-51-9	312.4	C₁₅H₂₀O₅S
CFN99075	Sulfocostunolide B	1059671-65-6	312.4	C₁₅H₂₀O₅S