Licoflavone A | CAS:61153-77-3 | Manufacturer ChemFaces

Licoflavone A

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Description:

Reference standards.

In vitro:

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401.

Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities[Pubmed: 20724155]

METHODS AND RESULTS:
Two new 2-arylbenzofurans, glycybenzofuran (1) and cyclolicocoumarone (2), together with 10 known flavonoids including licocoumarone (3), glycyrrhisoflavone (4), glisoflavone (5), cycloglycyrrhisoflavone (6), isoliquiritigenin (7), Licoflavone A (8), apigenin (9), isokaempferide (10), glycycoumarin (11), and isoglycycoumarin (12), were isolated from the roots of Glycyrrhiza uralensis and their structures were determined by extensive spectroscopic analyses. Compounds 1 and 5 showed significant protein tyrosine phosphatase-1B (PTP1B) inhibitory activity in vitro with the IC50 values of 25.5 and 27.9 μM, respectively.
CONCLUSIONS:
The structure–activity relationship indicated that the presence of prenyl group and ortho-hydroxy group is important for exhibiting the activity. Kinetic analysis indicated that compound 1 inhibits PTP1B by a competitive mode, whereas compound 5 by a mixed mode.

Licoflavone A Description

Source:	The roots of Glycyrrhiza inflata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Licoflavone A
Price:
CAS No.:	61153-77-3
Catalog No.:	CFN93265
Molecular Formula:	C₂₀H₁₈O₄
Molecular Weight:	322.36 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Glycyrrhiza inflata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1021 mL	15.5106 mL	31.0212 mL	62.0424 mL	77.553 mL
5 mM	0.6204 mL	3.1021 mL	6.2042 mL	12.4085 mL	15.5106 mL
10 mM	0.3102 mL	1.5511 mL	3.1021 mL	6.2042 mL	7.7553 mL
50 mM	0.062 mL	0.3102 mL	0.6204 mL	1.2408 mL	1.5511 mL
100 mM	0.031 mL	0.1551 mL	0.3102 mL	0.6204 mL	0.7755 mL

CFN92228	Corylifol C	775351-91-2	338.4	C₂₀H₁₈O₅
CFN96216	8,3'-Diprenylapigenin	955135-37-2	406.5	C₂₅H₂₆O₅
CFN97850	Honyucitrin	114542-44-8	406.48	C₂₅H₂₆O₅
CFN96217	Epimedokoreanin B	161068-53-7	422.5	C₂₅H₂₆O₆
CFN91891	Epimedokoreanin C	161068-54-8	454.47	C₂₅H₂₆O₈
CFN92321	5'-Geranyl-5,7,2',4'-tetrahydroxyflavone	1221762-70-4	422.5	C₂₅H₂₆O₆
CFN93300	Licoflavone B	91433-17-9	390.47	C₂₅H₂₆O₄
CFN92289	Licoflavone C	72357-31-4	338.4	C₂₀H₁₈O₅
CFN97991	Atalantoflavone	119309-02-3	336.3	C₂₀H₁₆O₅
CFN95851	Albanin D	134955-26-3	406.5	C₂₅H₂₆O₅