Science | Nature | Cell | View More
Natural Products
Lipiferolide
Lipiferolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lipiferolide
Price:
CAS No.: 41059-80-7
Catalog No.: CFN98642
Molecular Formula: C17H22O5
Molecular Weight: 306.4 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Liriodendron tulipifera
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Leibniz-Institut für Pflanzenb... (Germany)
  • Universidade da Beira Interior (Germany)
  • University of Lodz (Poland)
  • China Medical University (Taiwan)
  • The Ohio State University (USA)
  • Max Rubner-Institut (MRI) (Germany)
  • University of Sao Paulo (Brazil)
  • Instituto de Investigaciones Ag... (Chile)
  • Tohoku University (Japan)
  • Universidad Veracuzana (Mexico)
  • The University of Newcastle (Australia)
  • More...
Package
Featured Products
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Acetylshikonin

Catalog No: CFN90523
CAS No: 24502-78-1
Price: $138/20mg
Laricitrin

Catalog No: CFN70400
CAS No: 53472-37-0
Price: $ / mg
Harzianic acid

Catalog No: CFN00118
CAS No: 157148-06-6
Price: $ /
Brazilin

Catalog No: CFN98711
CAS No: 474-07-7
Price: $118/20mg
Panaxydol

Catalog No: CFN92797
CAS No: 72800-72-7
Price: $448/20mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
14-Deoxyandrographolide

Catalog No: CFN92802
CAS No: 4176-97-0
Price: $238/10mg
Dihydrophaseic acid

Catalog No: CFN98657
CAS No: 41756-77-8
Price: $ /
Kaempferol 3-O-arabinoside

Catalog No: CFN97572
CAS No: 99882-10-7
Price: $338/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.
Targets: Antifection | FPTase
In vitro:
Arch Pharm Res. 2007 Mar;30(3):299-302.
Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.[Pubmed: 17424934]

METHODS AND RESULTS:
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of Lipiferolide, an inhibitor of FPTase.
CONCLUSIONS:
This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.
Journal of Ethnopharmacology, 2011,133(1):26-30
Antiplasmodial Activity of Aporphine Alkaloids and Sesquiterpene Lactones from Liriodendron tulipifera L[Pubmed: 20826204 ]

METHODS AND RESULTS:
Six known aporphine alkaloids, asimilobine (1), norushinsunine (2), norglaucine (3), liriodenine (4), anonaine (5) and oxoglaucine (6) were found to be responsible for the antiplasmodial activity of the bark.
CONCLUSIONS:
Leaves yielded two known sesquiterpene lactones, peroxyferolide (7) and Lipiferolide (8) with antiplasmodial activity. The antiplasmodial activity of (2) (IC50 = 29.6 μg/ml), (3) (IC50 = 22.0 μg/ml), (6) (IC50= 9.1 μg/mL), (7) (IC50 = 6.2 μg/ml) and (8) (IC50 = 1.8 μg/ml) are reported for the first time.
Lipiferolide Description
Source: The herbs of Liriodendron tulipifera
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Pinocembroside

Catalog No: CFN95444
CAS No: 75829-43-5
Price: $118/20mg
(+)-Lariciresinol 4'-O-beta-D-Gluc...

Catalog No: CFN95283
CAS No: 639857-95-7
Price: $463/5mg
N-trans-p-Coumaroyltyrosine

Catalog No: CFN95279
CAS No: 77201-66-2
Price: $318/10mg
Isosaponarin 2''-O-glucoside (Isov...

Catalog No: CFN95296
CAS No: 63316-27-8
Price: $318/10mg
Parishin G

Catalog No: CFN95324
CAS No: 952283-93-1
Price: $318/10mg
Neoarctin B

Catalog No: CFN95243
CAS No: 155969-67-8
Price: $318/10mg
Tectoruside

Catalog No: CFN95051
CAS No: 38784-73-5
Price: $288/20mg
Crepidiaside B

Catalog No: CFN95432
CAS No: 101921-35-1
Price: $318/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2637 mL 16.3185 mL 32.6371 mL 65.2742 mL 81.5927 mL
5 mM 0.6527 mL 3.2637 mL 6.5274 mL 13.0548 mL 16.3185 mL
10 mM 0.3264 mL 1.6319 mL 3.2637 mL 6.5274 mL 8.1593 mL
50 mM 0.0653 mL 0.3264 mL 0.6527 mL 1.3055 mL 1.6319 mL
100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.6527 mL 0.8159 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Phytochemistry,1975,14(3):769-73.
New sesquiterpene lactones from Liriodendron tulipifera.[Reference: WebLink]

METHODS AND RESULTS:
Four new sesquiterpene lactones were obtained from L. tulipifera; two germacranolides, Lipiferolide (4) and Epitulipinolide diepoxide (5) from the leaves, an elemanolide, epitulipdienolide (7), and an eudesmanolide, γ-liriodenolide (6) from the root bark. Structural determination was by physical and chemical methods and by direct correlation to the known epitulipinolide (3).
CONCLUSIONS:
Lipiferolide and Epitulipinolide diepoxide possess cytotoxic activity against KB cells.
4-Hydroxybenzyl alcohol

Catalog No: CFN97071
CAS No: 623-05-2
Price: $30/20mg
Acetylshikonin

Catalog No: CFN90523
CAS No: 24502-78-1
Price: $138/20mg
Laricitrin

Catalog No: CFN70400
CAS No: 53472-37-0
Price: $ / mg
Harzianic acid

Catalog No: CFN00118
CAS No: 157148-06-6
Price: $ /
Brazilin

Catalog No: CFN98711
CAS No: 474-07-7
Price: $118/20mg
Panaxydol

Catalog No: CFN92797
CAS No: 72800-72-7
Price: $448/20mg
Polyphyllin II

Catalog No: CFN99953
CAS No: 76296-72-5
Price: $/mg
14-Deoxyandrographolide

Catalog No: CFN92802
CAS No: 4176-97-0
Price: $238/10mg
Dihydrophaseic acid

Catalog No: CFN98657
CAS No: 41756-77-8
Price: $ /
Kaempferol 3-O-arabinoside

Catalog No: CFN97572
CAS No: 99882-10-7
Price: $338/5mg
Tags: buy Lipiferolide | Lipiferolide supplier | purchase Lipiferolide | Lipiferolide cost | Lipiferolide manufacturer | order Lipiferolide | Lipiferolide distributor