Lipiferolide | CAS:41059-80-7 | Manufacturer ChemFaces

Lipiferolide

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.

Targets:

Antifection | FPTase

In vitro:

Arch Pharm Res. 2007 Mar;30(3):299-302.

Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera.[Pubmed: 17424934]

METHODS AND RESULTS:
The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of Lipiferolide, an inhibitor of FPTase.
CONCLUSIONS:
This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

Journal of Ethnopharmacology, 2011,133(1):26-30

Antiplasmodial Activity of Aporphine Alkaloids and Sesquiterpene Lactones from Liriodendron tulipifera L[Pubmed: 20826204 ]

METHODS AND RESULTS:
Six known aporphine alkaloids, asimilobine (1), norushinsunine (2), norglaucine (3), liriodenine (4), anonaine (5) and oxoglaucine (6) were found to be responsible for the antiplasmodial activity of the bark.
CONCLUSIONS:
Leaves yielded two known sesquiterpene lactones, peroxyferolide (7) and Lipiferolide (8) with antiplasmodial activity. The antiplasmodial activity of (2) (IC50 = 29.6 μg/ml), (3) (IC50 = 22.0 μg/ml), (6) (IC50= 9.1 μg/mL), (7) (IC50 = 6.2 μg/ml) and (8) (IC50 = 1.8 μg/ml) are reported for the first time.

Lipiferolide Description

Source:	The herbs of Liriodendron tulipifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Lipiferolide
Price:
CAS No.:	41059-80-7
Catalog No.:	CFN98642
Molecular Formula:	C₁₇H₂₂O₅
Molecular Weight:	306.4 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The herbs of Liriodendron tulipifera
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Antimalaric Compound Library Sesquiterpenoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2637 mL	16.3185 mL	32.6371 mL	65.2742 mL	81.5927 mL
5 mM	0.6527 mL	3.2637 mL	6.5274 mL	13.0548 mL	16.3185 mL
10 mM	0.3264 mL	1.6319 mL	3.2637 mL	6.5274 mL	8.1593 mL
50 mM	0.0653 mL	0.3264 mL	0.6527 mL	1.3055 mL	1.6319 mL
100 mM	0.0326 mL	0.1632 mL	0.3264 mL	0.6527 mL	0.8159 mL

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