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3. Inhibitors
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $308.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Br J Pharmacol.2016, 173(2):396-410Food Addit Contam Part A....2021...South African J of Plant&Soil...2018...Phytomedicine.2018, 38:45-56The Korea Journal of Herbology...2016...Evid Based Complement Alternat Me...2017...Cell Death Dis.2019, 10(12):882Asian Pac J Cancer Prev....2019...
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Our products had been exported to the following research institutions and universities, And still growing.
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Lucidenic acid D2
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manager@chemfaces.com
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service@chemfaces.com
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Int J Mol Sci.2021, 22(21):11447.Int J Mol Sci.2017, 18(5)Pharmacognosy Journal.2020, 12(2), p232-235.Int J Mol Sci.2021, 22(19):10220.Int J Mol Sci.2021, 22(11):5503.Food Res Int.2019, 123:125-134Processes2020, 8(12),1540.Pharm Biol.2017, 55(1):360-366Biochemistry.2018, 57(40):5886-5896Front Pharmacol.2021, 12:635510.
Related Screening Libraries
| Description: |
Lucidenic acid D2 is a nartural product from G. lucidum AF. |
| Targets: |
TNF-α | p38MAPK |
| In vitro: |
| Biochem Biophys Res Commun. 2011 Apr 29;408(1):18-24. | | Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.[Pubmed: 21453678 ] | The Ganoderma lucidum (G. lucidum) is one of the oriental fungi that has been reported to have immunomodulatory properties. Although effect of β-glucans from G. lucidum has been well documented, little is known about how other major bioactive components, the triterpenes, contribute to the immunomodulatory function of G. lucidum.
METHODS AND RESULTS:
Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα production, while JNK inhibitor enhanced TNFα production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Moreover, we found that the triterpenes-rich extract of G. lucidum AF contains high amounts of lucidenic acids. Lucidenic acid A, Lucidenic acid F and Lucidenic acid D2, which seem to dominantly exist in the extract, were purified from the triterpenes-rich extract. We also identified Lucidenic acid-A and -F as modulators of JNK and p38, respectively.
CONCLUSIONS:
Thus, our data demonstrate that lucidenic acids-rich extract from G. lucidum AF enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation. |
|
| In vivo: |
| Planta Medica, 2015, 81(11). | | Biological activities of triterpenes isolated from the medicinal mushroom Ganoderma lucidum.[Reference: WebLink] |
METHODS AND RESULTS:
Methanol extract of Ganoderma lucidum subjected to fractionation on silica gel medium pressure column afforded over 40 fractions. Further fractionation was carried out using Centrifugal Partition Chromatography (FCPC Rousselet Robatel, France), in the hexane-EtOAc-MeOH-Water systems adjusted for the polarity of each fraction. Some isolates were further purified by preparative HPLC. Methyl esters of ganoderic and lucidenic acids were obtained by methylation of the acids. Twelve compounds, including ganoderic acid A (1), methyl ganoderate A (2), methyl lucidenate A (3), methyl lucidenate F (4), Lucidenic acid D2 (5), lucidenic acid A (6), lucidenic acid N (7), ganoderic acid DM (8), ganoderic acid F (9), ganoderic acid C (10), ganoderiol F (11) and ganodermonondiol (12) were evaluated for their biological activities. Antibacterial activity was determined against Gram -positive and -negative bacteria, anti-inflammatory effect against endotoxin (lipolysaccharide, LPS) induced inflammatory response in human macrophages, and anti-proliferative effects in human breast and colon cancer cells.
CONCLUSIONS:
We identified ganoderic acid DM as the most potent triterpene with anti-bacterial, anti-inflammatory and anti-proliferative effects when compared to other Ganoderma isolates. |
|
Lucidenic acid D2 Description
| Source: |
The fruit body of Ganoderma lucidum |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9433 mL |
9.7163 mL |
19.4326 mL |
38.8651 mL |
48.5814 mL |
| 5 mM |
0.3887 mL |
1.9433 mL |
3.8865 mL |
7.773 mL |
9.7163 mL |
| 10 mM |
0.1943 mL |
0.9716 mL |
1.9433 mL |
3.8865 mL |
4.8581 mL |
| 50 mM |
0.0389 mL |
0.1943 mL |
0.3887 mL |
0.7773 mL |
0.9716 mL |
| 100 mM |
0.0194 mL |
0.0972 mL |
0.1943 mL |
0.3887 mL |
0.4858 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
