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| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
RSC Adv.2018, 32621-32636Chin Med.2022, 17(1):66. Medicina (Kaunas).2020, 56(12):685.Food Chem.2019, 278:683-691Asian Journal of Chemistry...2014...Pharmaceuticals.2022, 15(4), 402.Institute of Food Science & Techn...2021...Food Science and Biotechnology...2022...
In Vivo.2022, 36(3):1136-1143. Int. Conference on Med. Sci. and ...2017...Molecules.2019, 24(22):E4022Evid Based Complement Alternat Me...2017...BMC Plant Biol.2018, 18(1):122Viruses.2017, 9(10)Universitat Stuttgart2022, opus-12200.J Food Sci.2022, 87(11):4905-4916.
J Mol Med (Berl).2018, 96(7):661-672Biomedicine & Pharmacotherapy...2020...Korean J. Food Sci. & Technol....2022...J of the Society of Cosmetic Scie...2018...Eur J Pharmacol.2021, 899:174010. Sci Rep. 2018, 462(8)Life (Basel).2022, 12(12):2107.
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Our products had been exported to the following research institutions and universities, And still growing.
Universidade Federal de Pernamb... (Brazil)Julius Kühn-Institut (Germany)The Ohio State University (USA)University of Leipzig (Germany)
CSIRO - Agriculture Flagship (Australia)National Cancer Institute (USA)Kamphaengphet Rajabhat University (Thailand)Seoul National University (Korea)
Instituto de Investigaciones Ag... (Chile)The Vancouver Prostate Centre (... (Canada)Tokyo Woman's Christian University (Japan)
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Medioresinol
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manager@chemfaces.com
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PLoS One.2018, 13(4):e0195642Analytical sci. & Tech2020, 33(5):224-231Molecules.2020, 25(23):5556. Bio-protocol2018, 9(14):e3301Toxicol Rep.2021, 8:1131-1142. Universidade Estadual Paulista2017, 11449J Nat Med.2020, 74(1):65-75Pharmaceuticals (Basel).2022, 15(5):591. J Med Food.2021, 24(3):209-217.Int J Mol Sci.2017, 19(1)
Related Screening Libraries
| Description: |
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of β-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease. (+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities. |
| Targets: |
ROS | Beta Amyloid | Antifection |
| In vitro: |
| Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41. | | Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro.[Pubmed: 23797511 ] |
METHODS AND RESULTS:
In this study, antibacterial effects of (+)-Medioresinol isolated from stem bark of Sambucus williamsii and its synergistic activities in combination with antibiotics such as ampicillin, cefotaxime, and chloramphenicol were tested by antibacterial susceptibility testing and checkerboard assay. (+)-Medioresinol possessed antibacterial effects against antibiotics-susceptible- or antibiotics-resistant strains. Most of combinations between (+)-Medioresinol and each antibiotic showed synergistic interaction (fractional inhibitory concentration index ≤ 0.5) against bacterial strains including antibiotics-resistant Pseudomonas aeruginosa. Furthermore, the antibiofilm effect of (+)-Medioresinol alone or in combination with each antibiotic was investigated.
CONCLUSIONS:
The results indicated that not only (+)-Medioresinol but also its combination with each antibiotic had antibiofilm activities. It concludes that (+)-Medioresinol has potential as a therapeutic agent and adjuvant for treatment of bacterial infection. | | Biochimie. 2012 Aug;94(8):1784-93. | | (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans.[Pubmed: 22534194] | The phytochemical (+)-Medioresinol, a furofuran type lignan identification and isolation on the stem bark of Sambucus williamsii, which is a folk medicinal plant used in traditional medicine. (+)-Medioresinol is known to possess a lesishmanicidal activity and cardiovascular disease risk reduction but its antifungal effects have not yet been identified.
METHODS AND RESULTS:
In this study, to confirm (+)-Medioresinol's antifungal properties and mode of action, we observed morphological and physiological change in Candida albicans. In cells exposed to (+)-Medioresinol, arrested the cell cycle and intracellular reactive oxygen species (ROS) which is a major cause of apoptosis were increased. The increase of ROS induced oxidative stress and the mitochondria dysfunction which causes release of pro-apoptotic factors. We investigated a series of characteristic cellular changes of apoptosis by using various apoptosis detection methods. We report here for the first time that (+)-Medioresinol has effects on mitochondria and induced the accumulation of ROS in C. albicans cells. we investigated the release of cytochrome c, which is one of the factors of metacaspase activity. We also show that the effects of (+)-Medioresinol are mediated at an early stage in apoptosis acting on the plasma membrane phosphatidylserine externalization. In addition, (+)-Medioresinol induced apoptotic morphological changes, showing the reduced cell size (low FSC) and enhanced intracellular density (high SSC). In late stage of confirmation of diagnostic markers in yeast apoptosis include the effects of nucleus morphological change, DNA fragmentation and condensation by influence of oxidative stress.
CONCLUSIONS:
These apoptotic phenomena represent that oxidative stress and mitochondria dysfunctions by inducing the phytochemical (+)-Medioresinol must be an important factors of the apoptotic process in C. albicans. These results support the elucidation of the underlying antifungal mechanisms of (+)-Medioresinol. |
|
Medioresinol Description
| Source: |
The herbs of Allamanda neriifolia |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.5747 mL |
12.8733 mL |
25.7467 mL |
51.4933 mL |
64.3666 mL |
| 5 mM |
0.5149 mL |
2.5747 mL |
5.1493 mL |
10.2987 mL |
12.8733 mL |
| 10 mM |
0.2575 mL |
1.2873 mL |
2.5747 mL |
5.1493 mL |
6.4367 mL |
| 50 mM |
0.0515 mL |
0.2575 mL |
0.5149 mL |
1.0299 mL |
1.2873 mL |
| 100 mM |
0.0257 mL |
0.1287 mL |
0.2575 mL |
0.5149 mL |
0.6437 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Cell Research: |
| Nutr Res. 2016 Nov;36(11):1277-1284. | | Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein.[Pubmed: 27865616 ] | β-Amyloid (Aβ) is a substance of Alzheimer disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD.
METHODS AND RESULTS:
The methanol extract of cinnamon bark efficiently reduced Aβ40 production in Chinese hamster ovarian (CHO) cells stably expressing APP as determined by enzyme-linked immunosorbent assay. Bioassay-guided isolation of cinnamon bark extract was carried out using open column chromatography and high-performance liquid chromatography, and the following 6 phenylpropanoids were isolated: syringaresinol (1); Medioresinol (2); coumarin (3); 2-hydroxycinnamaldehyde (4); cryptamygin A (5); and 3',5,7-trimethoxy epicatechin (6). Among these, 4 μg/mL Medioresinol and cryptamygin A reduced Aβ40 production by 50% and 60%, respectively, compared with dimethyl sulfoxide-treated control cells. The IC50 values of Medioresinol and cryptamygin A for the inhibition of Aβ40 production were 10.8 and 8.2 μg/mL, respectively. Furthermore, treatment of APP-CHO cells with either compound decreased the amount of β-secretase and sAPPβ (the proteolytic fragment of APP catalyzed by β-secretase).
CONCLUSIONS:
These results suggest that the antiamyloidogenic activity of cinnamon bark extract was exerted by Medioresinol and cryptamygin A via a reduction in the amount of β-secretase. The extract of cinnamon bark contains potentially valuable antiamyloidogenic agents for the prevention and treatment of AD. |
|
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