Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    CAS No. 40957-99-1 Price
    Catalog No.CFN98641Purity>=98%
    Molecular Weight388.4 Type of CompoundLignans
    FormulaC21H24O7Physical DescriptionPowder
    Download COA    MSDS    SDF    ManualSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email:
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • Universidade Federal de Pernamb... (Brazil)
  • Julius Kühn-Institut (Germany)
  • The Ohio State University (USA)
  • University of Leipzig (Germany)
  • CSIRO - Agriculture Flagship (Australia)
  • National Cancer Institute (USA)
  • Kamphaengphet Rajabhat University (Thailand)
  • Seoul National University (Korea)
  • Instituto de Investigaciones Ag... (Chile)
  • The Vancouver Prostate Centre (... (Canada)
  • Tokyo Woman's Christian University (Japan)
  • More...
  • Package
    Featured Products

    Catalog No: CFN92218
    CAS No: 4443-09-8
    Price: $318/20mg
    Terrestrosin D

    Catalog No: CFN90821
    CAS No: 179464-23-4
    Price: $168/10mg

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Ginsenoside Re

    Catalog No: CFN99974
    CAS No: 52286-59-6
    Price: $40/20mg

    Catalog No: CFN92376
    CAS No: 472-28-6
    Price: $388/5mg

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg


    Product Name Medioresinol
    CAS No.: 40957-99-1
    Catalog No.: CFN98641
    Molecular Formula: C21H24O7
    Molecular Weight: 388.4 g/mol
    Purity: >=98%
    Type of Compound: Lignans
    Physical Desc.: Powder
    Targets: ROS | Beta Amyloid | Antifection
    Source: The herbs of Allamanda neriifolia
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Download: COA    MSDS    SDF    Manual
    Similar structural: Comparison (Web)  (SDF)
    Inquire / Order:
    Technical Inquiries:
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • PLoS One.2018, 13(4):e0195642
  • Analytical sci. & Tech2020, 33(5):224-231
  • Molecules.2020, 25(23):5556.
  • Bio-protocol2018, 9(14):e3301
  • Toxicol Rep.2021, 8:1131-1142.
  • Universidade Estadual Paulista2017, 11449
  • J Nat Med.2020, 74(1):65-75
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • J Med Food.2021, 24(3):209-217.
  • Int J Mol Sci.2017, 19(1)
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antioxidants Compound Library
  • Antibacterial Compound Library
  • Antifungal Compound Library
  • Anti-leishmanial Compound Library
  • Cardiovascular protection Compound Library
  • Lignans Compound Library
  • ROS Inhibitor Library
  • Beta Amyloid Inhibitor Library
  • Antifection Inhibitor Library
  • Biological Activity
    Description: Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of β-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease. (+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities.
    Targets: ROS | Beta Amyloid | Antifection
    In vitro:
    Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41.
    Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro.[Pubmed: 23797511 ]

    In this study, antibacterial effects of (+)-Medioresinol isolated from stem bark of Sambucus williamsii and its synergistic activities in combination with antibiotics such as ampicillin, cefotaxime, and chloramphenicol were tested by antibacterial susceptibility testing and checkerboard assay. (+)-Medioresinol possessed antibacterial effects against antibiotics-susceptible- or antibiotics-resistant strains. Most of combinations between (+)-Medioresinol and each antibiotic showed synergistic interaction (fractional inhibitory concentration index ≤ 0.5) against bacterial strains including antibiotics-resistant Pseudomonas aeruginosa. Furthermore, the antibiofilm effect of (+)-Medioresinol alone or in combination with each antibiotic was investigated.
    The results indicated that not only (+)-Medioresinol but also its combination with each antibiotic had antibiofilm activities. It concludes that (+)-Medioresinol has potential as a therapeutic agent and adjuvant for treatment of bacterial infection.
    Biochimie. 2012 Aug;94(8):1784-93.
    (+)-Medioresinol leads to intracellular ROS accumulation and mitochondria-mediated apoptotic cell death in Candida albicans.[Pubmed: 22534194]
    The phytochemical (+)-Medioresinol, a furofuran type lignan identification and isolation on the stem bark of Sambucus williamsii, which is a folk medicinal plant used in traditional medicine. (+)-Medioresinol is known to possess a lesishmanicidal activity and cardiovascular disease risk reduction but its antifungal effects have not yet been identified.
    In this study, to confirm (+)-Medioresinol's antifungal properties and mode of action, we observed morphological and physiological change in Candida albicans. In cells exposed to (+)-Medioresinol, arrested the cell cycle and intracellular reactive oxygen species (ROS) which is a major cause of apoptosis were increased. The increase of ROS induced oxidative stress and the mitochondria dysfunction which causes release of pro-apoptotic factors. We investigated a series of characteristic cellular changes of apoptosis by using various apoptosis detection methods. We report here for the first time that (+)-Medioresinol has effects on mitochondria and induced the accumulation of ROS in C. albicans cells. we investigated the release of cytochrome c, which is one of the factors of metacaspase activity. We also show that the effects of (+)-Medioresinol are mediated at an early stage in apoptosis acting on the plasma membrane phosphatidylserine externalization. In addition, (+)-Medioresinol induced apoptotic morphological changes, showing the reduced cell size (low FSC) and enhanced intracellular density (high SSC). In late stage of confirmation of diagnostic markers in yeast apoptosis include the effects of nucleus morphological change, DNA fragmentation and condensation by influence of oxidative stress.
    These apoptotic phenomena represent that oxidative stress and mitochondria dysfunctions by inducing the phytochemical (+)-Medioresinol must be an important factors of the apoptotic process in C. albicans. These results support the elucidation of the underlying antifungal mechanisms of (+)-Medioresinol.
    Medioresinol Description
    Source: The herbs of Allamanda neriifolia
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to:

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    New compound 2

    Catalog No: CFN95181
    CAS No: N/A
    Price: $318/5mg
    Malabaricone C

    Catalog No: CFN95475
    CAS No: 63335-25-1
    Price: $318/10mg

    Catalog No: CFN95030
    CAS No: 941269-84-7
    Price: $368/5mg
    Ganoweberianic acid E

    Catalog No: CFN95504
    CAS No: 1309931-90-5
    Price: $413/5mg
    Picraquassioside B

    Catalog No: CFN95378
    CAS No: 169312-05-4
    Price: $318/10mg
    (E)-6-O-(p-coumaroyl)scandoside me...

    Catalog No: CFN95192
    CAS No: 83946-90-1
    Price: $218/10mg

    Catalog No: CFN95084
    CAS No: 141846-47-1
    Price: $413/5mg
    Eschweilenol C

    Catalog No: CFN95363
    CAS No: 211371-02-7
    Price: $318/10mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.5747 mL 12.8733 mL 25.7467 mL 51.4933 mL 64.3666 mL
    5 mM 0.5149 mL 2.5747 mL 5.1493 mL 10.2987 mL 12.8733 mL
    10 mM 0.2575 mL 1.2873 mL 2.5747 mL 5.1493 mL 6.4367 mL
    50 mM 0.0515 mL 0.2575 mL 0.5149 mL 1.0299 mL 1.2873 mL
    100 mM 0.0257 mL 0.1287 mL 0.2575 mL 0.5149 mL 0.6437 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Cell Research:
    Nutr Res. 2016 Nov;36(11):1277-1284.
    Phenylpropanoids from cinnamon bark reduced β-amyloid production by the inhibition of β-secretase in Chinese hamster ovarian cells stably expressing amyloid precursor protein.[Pubmed: 27865616 ]
    β-Amyloid (Aβ) is a substance of Alzheimer disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD.
    The methanol extract of cinnamon bark efficiently reduced Aβ40 production in Chinese hamster ovarian (CHO) cells stably expressing APP as determined by enzyme-linked immunosorbent assay. Bioassay-guided isolation of cinnamon bark extract was carried out using open column chromatography and high-performance liquid chromatography, and the following 6 phenylpropanoids were isolated: syringaresinol (1); Medioresinol (2); coumarin (3); 2-hydroxycinnamaldehyde (4); cryptamygin A (5); and 3',5,7-trimethoxy epicatechin (6). Among these, 4 μg/mL Medioresinol and cryptamygin A reduced Aβ40 production by 50% and 60%, respectively, compared with dimethyl sulfoxide-treated control cells. The IC50 values of Medioresinol and cryptamygin A for the inhibition of Aβ40 production were 10.8 and 8.2 μg/mL, respectively. Furthermore, treatment of APP-CHO cells with either compound decreased the amount of β-secretase and sAPPβ (the proteolytic fragment of APP catalyzed by β-secretase).
    These results suggest that the antiamyloidogenic activity of cinnamon bark extract was exerted by Medioresinol and cryptamygin A via a reduction in the amount of β-secretase. The extract of cinnamon bark contains potentially valuable antiamyloidogenic agents for the prevention and treatment of AD.

    Catalog No: CFN92218
    CAS No: 4443-09-8
    Price: $318/20mg
    Terrestrosin D

    Catalog No: CFN90821
    CAS No: 179464-23-4
    Price: $168/10mg

    Catalog No: CFN92233
    CAS No: 550-43-6
    Price: $490/5mg
    Ginsenoside Re

    Catalog No: CFN99974
    CAS No: 52286-59-6
    Price: $40/20mg

    Catalog No: CFN92376
    CAS No: 472-28-6
    Price: $388/5mg

    Catalog No: CFN92150
    CAS No: 93859-63-3
    Price: $418/5mg
    Deapi-platycoside E

    Catalog No: CFN92355
    CAS No: 849758-42-5
    Price: $268/5mg
    Tags: buy Medioresinol | Medioresinol supplier | purchase Medioresinol | Medioresinol cost | Medioresinol manufacturer | order Medioresinol | Medioresinol distributor