Info: Read More
  • Home
  • Natural Products
  • Bioactive
  • Screening Libraries
  • Hot Products
  • Plant Catalog
  • Customer Support
  • Product Use Citation
  • About Us
  • Contact Us
  • How to Order
  • Delivery time
  • Science | Nature | Cell | View More
    Natural Products
    Menisperine
    Menisperine
    Information
    CAS No. 25342-82-9 Price $318 / 10mg
    Catalog No.CFN95318Purity>=98%
    Molecular Weight356.4Type of CompoundAlkaloids
    FormulaC21H26NO4Physical DescriptionPowder
    Download COA    MSDSSimilar structuralComparison (Web)  (SDF)
    Citing Use of our Products
    How to Order
    Orders via your E-mail:

    1. Product number / Name / CAS No.
    2. Delivery address
    3. Ordering/billing address
    4. Contact information
    Sent to Email: info@chemfaces.com
    Contact Us
    Order & Inquiry & Tech Support

    Tel: (0086)-27-84237683
    Fax: (0086)-27-84254680
    E-mail: manager@chemfaces.com
    Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
    Delivery time
    Delivery & Payment method

    1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

    2. We accept: Wire transfer & Credit card & Paypal & Western Union
    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $175.7 / In-stock
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
    Our products had been exported to the following research institutions and universities, And still growing.
  • University of Vienna (Austria)
  • Kyung Hee University (Korea)
  • Florida A&M University (USA)
  • Complutense University of Madrid (Spain)
  • St. Jude Children Research Hosp... (USA)
  • University of Wuerzburg (Germany)
  • University of Melbourne (Australia)
  • Fraunhofer-Institut für Moleku... (Germany)
  • Universidad de Buenos Aires (Argentina)
  • Calcutta University (India)
  • Istanbul University (Turkey)
  • More...
  • Package
    Featured Products
    Niranthin

    Catalog No: CFN98798
    CAS No: 50656-77-4
    Price: $453/5mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Dictamnine

    Catalog No: CFN99783
    CAS No: 484-29-7
    Price: $100/20mg
    Ginsenoside Rh3

    Catalog No: CFN99972
    CAS No: 105558-26-7
    Price: $218/5mg
    Shikonin

    Catalog No: CFN99907
    CAS No: 517-88-4
    Price: $80/20mg
    Germacrone

    Catalog No: CFN98133
    CAS No: 6902-91-6
    Price: $30/20mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg

    Menisperine

    Menisperine
    Product Name Menisperine
    CAS No.: 25342-82-9
    Catalog No.: CFN95318
    Molecular Formula: C21H26NO4
    Molecular Weight: 356.4 g/mol
    Purity: >=98%
    Type of Compound: Alkaloids
    Physical Desc.: Powder
    Targets: NF-魏B
    Source: The barks of Phellodendron chinense
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $318 / 10mg
    Download: COA    MSDS
    Similar structural: Comparison (Web)  (SDF)
    Inquire / Order: manager@chemfaces.com
    Technical Inquiries: service@chemfaces.com
    Tel: +86-27-84237783
    Fax: +86-27-84254680

    Address:
    1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
  • Chin J Appl. Physiol.2019, 35(3):283-288
  • J Pharm Biomed Anal.2018, 151:32-41
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
  • Food Chem.2018, 252:207-214
  • J Asian Nat Prod Res.2019, 5:1-17
  • J Ethnopharmacol.2020, 260:112988.
  • Am J Chin Med.2016, 44(6):1255-1271
  • Applied Biological Chemistry2022, 65(12)
  • Appl. Sci.2022, 12(4), 2032.
  • Molecules.2022, 27(5):1675
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Anti-inflammatory Compound Library
  • Alkaloids Compound Library
  • Biological Activity
    Description: Anti-inflammatory effects (potential NF-κB inhibitors).
    Targets: NF-κB
    In vitro:
    Biomed Chromatogr . 2016 Nov;30(11):1843-1853
    Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β 2- AR agonizing activities[Pubmed: 27187693]
    Caulis Sinomenii (CS) is a valuable traditional medicine in China. Its extract can act as an anti-inflammatory agent and a vascular smooth muscle relaxant. However, the underlying mechanisms remain unknown. In this study, we developed a simple dual-target method based on ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry combined with a dual-target bioactive screening assay for anti-inflammatory and antispasmodic activities to characterize the chemical structure of various bioactive compounds of CS rapidly. Seven potential NF-κB inhibitors were identified, including laudanosoline-1-O-xylopyranose, 6-O-methyl-laudanosoline-1-O-glucopyranoside, Menisperine, sinomenine, laurifoline, magnoflorine and norsinoacutin. Furthermore, IL-6 and IL-8 assays confirmed the anti-inflammatory effects of these potential NF-κB inhibitors, in which laudanosoline-1-O-d-xylopyranose and Menisperine were revealed as novel NF-κB inhibitors. Among the seven identified alkaloids, three potential β2 -adrenergic receptor agonists, including sinomenine, magnoflorine and laurifoline, were characterized using a luciferase reporter system to measure for the activity of β2 -adrenergic receptor agonists. Finally, sinomenine, magnoflorine and laurifoline were identified not only as potential NF-κB inhibitors but also as potential β2 -adrenegic receptor agonists, which is the first time this has been reported. Molecular dynamic simulation and docking results suggest that the three dual-bioactive constituents could not only inhibit Pseudomonas aeruginosa PAK strain-induced inflammatory responses via a negative regulation of the Braf protein that participates in MAPK signaling pathway but also activate the β2 -adrenegic receptor. These results suggest that CS extract has dual signaling activities with potential clinical application as a novel drug for asthma.
    Menisperine Description
    Source: The barks of Phellodendron chinense
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
    ChemFaces New Products and Compounds
    Rhamnocitrin 3-galactoside

    Catalog No: CFN95474
    CAS No: 99878-05-4
    Price: $318/10mg
    Theaflavanoside II

    Catalog No: CFN95380
    CAS No: 943785-09-9
    Price: $318/5mg
    Caohuoside E

    Catalog No: CFN95016
    CAS No: 174286-23-8
    Price: $388/5mg
    Ampelopsin G

    Catalog No: CFN95148
    CAS No: 151487-09-1
    Price: $318/5mg
    Isospinosin

    Catalog No: CFN95350
    CAS No: 89701-83-7
    Price: $318/5mg
    Asiaticoside B

    Catalog No: CFN95124
    CAS No: 125265-68-1
    Price: $188/20mg
    Daucoidin A

    Catalog No: CFN95275
    CAS No: 103629-87-4
    Price: $318/5mg
    3-Acetyl-ginsenoside F1

    Catalog No: CFN95238
    CAS No: 1881225-08-6
    Price: $318/5mg
    Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8058 mL 14.0292 mL 28.0584 mL 56.1167 mL 70.1459 mL
    5 mM 0.5612 mL 2.8058 mL 5.6117 mL 11.2233 mL 14.0292 mL
    10 mM 0.2806 mL 1.4029 mL 2.8058 mL 5.6117 mL 7.0146 mL
    50 mM 0.0561 mL 0.2806 mL 0.5612 mL 1.1223 mL 1.4029 mL
    100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.5612 mL 0.7015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Nat Prod Res . 2018 Feb;32(3):354-357
    Qualitative and quantitative analysis of chemical constituents of Ptychopetalum olacoides Benth[Pubmed: 28750557]
    Ptychopetalum olacoides is a folk medicinal plant for health care in market, especially in Brazil. Fourteen known compounds were isolated from P. olacoides and their chemical structures were elucidated by extensive spectroscopic data, including 1D NMR, 2D NMR, UV, IR and HR-ESI-MS. The 14 known compounds were identified as N-trans-feruloyl-3,5-dihydroxyindolin-2-one (1), magnoflorine (2), Menisperine (3), 4-coumaroylserotonin (4), moschamine (5), luteolin (6), 4'-methoxyluteolin (7), 3-methoxyluteolin (8), 3, 7-dimethoxyluteolin (9), caffeic acid (10), ferulic acid (11), vanillic acid (12), syringic acid (13) and ginsenoside Re (14). To our knowledge, compounds (1-6, 13-14) were isolated from the plant for the first time. Additionally, quantitative analysis results indicated that calibration equations of compounds (1-3, 6, 9, 11-13) exhibited good linear regressions within the test ranges (R2 ≥ 0.9990) and magnoflorine and Menisperine were the major constituents in the barks of P. olacoides. The contents of magnoflorine and Menisperine accounted for 75.96% of all analytes. However, the content of phenolic components was smaller and the highest content was no more than 1.04 mg/g. Collectively, these results suggested that alkaloids are the dominant substances in P. olacoides, which can make a difference for the quality control and further use of P. olacoides.
    Niranthin

    Catalog No: CFN98798
    CAS No: 50656-77-4
    Price: $453/5mg
    Przewaquinone A

    Catalog No: CFN92022
    CAS No: 76843-23-7
    Price: $338/5mg
    Dictamnine

    Catalog No: CFN99783
    CAS No: 484-29-7
    Price: $100/20mg
    Ginsenoside Rh3

    Catalog No: CFN99972
    CAS No: 105558-26-7
    Price: $218/5mg
    Shikonin

    Catalog No: CFN99907
    CAS No: 517-88-4
    Price: $80/20mg
    Germacrone

    Catalog No: CFN98133
    CAS No: 6902-91-6
    Price: $30/20mg
    Decursitin D

    Catalog No: CFN95002
    CAS No: 245446-61-1
    Price: $388/5mg
    Tags: buy Menisperine | Menisperine supplier | purchase Menisperine | Menisperine cost | Menisperine manufacturer | order Menisperine | Menisperine distributor