Menisperine | CAS:25342-82-9 | Manufacturer ChemFaces

Menisperine

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Description:

Anti-inflammatory effects (potential NF-κB inhibitors).

Targets:

NF-κB

In vitro:

Biomed Chromatogr . 2016 Nov;30(11):1843-1853

Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β 2- AR agonizing activities[Pubmed: 27187693]

Caulis Sinomenii (CS) is a valuable traditional medicine in China. Its extract can act as an anti-inflammatory agent and a vascular smooth muscle relaxant. However, the underlying mechanisms remain unknown. In this study, we developed a simple dual-target method based on ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry combined with a dual-target bioactive screening assay for anti-inflammatory and antispasmodic activities to characterize the chemical structure of various bioactive compounds of CS rapidly. Seven potential NF-κB inhibitors were identified, including laudanosoline-1-O-xylopyranose, 6-O-methyl-laudanosoline-1-O-glucopyranoside, Menisperine, sinomenine, laurifoline, magnoflorine and norsinoacutin. Furthermore, IL-6 and IL-8 assays confirmed the anti-inflammatory effects of these potential NF-κB inhibitors, in which laudanosoline-1-O-d-xylopyranose and Menisperine were revealed as novel NF-κB inhibitors. Among the seven identified alkaloids, three potential β2 -adrenergic receptor agonists, including sinomenine, magnoflorine and laurifoline, were characterized using a luciferase reporter system to measure for the activity of β2 -adrenergic receptor agonists. Finally, sinomenine, magnoflorine and laurifoline were identified not only as potential NF-κB inhibitors but also as potential β2 -adrenegic receptor agonists, which is the first time this has been reported. Molecular dynamic simulation and docking results suggest that the three dual-bioactive constituents could not only inhibit Pseudomonas aeruginosa PAK strain-induced inflammatory responses via a negative regulation of the Braf protein that participates in MAPK signaling pathway but also activate the β2 -adrenegic receptor. These results suggest that CS extract has dual signaling activities with potential clinical application as a novel drug for asthma.

Menisperine Description

Source:	The barks of Phellodendron chinense
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Nat Prod Res . 2018 Feb;32(3):354-357

Qualitative and quantitative analysis of chemical constituents of Ptychopetalum olacoides Benth[Pubmed: 28750557]

Ptychopetalum olacoides is a folk medicinal plant for health care in market, especially in Brazil. Fourteen known compounds were isolated from P. olacoides and their chemical structures were elucidated by extensive spectroscopic data, including 1D NMR, 2D NMR, UV, IR and HR-ESI-MS. The 14 known compounds were identified as N-trans-feruloyl-3,5-dihydroxyindolin-2-one (1), magnoflorine (2), Menisperine (3), 4-coumaroylserotonin (4), moschamine (5), luteolin (6), 4'-methoxyluteolin (7), 3-methoxyluteolin (8), 3, 7-dimethoxyluteolin (9), caffeic acid (10), ferulic acid (11), vanillic acid (12), syringic acid (13) and ginsenoside Re (14). To our knowledge, compounds (1-6, 13-14) were isolated from the plant for the first time. Additionally, quantitative analysis results indicated that calibration equations of compounds (1-3, 6, 9, 11-13) exhibited good linear regressions within the test ranges (R2 ≥ 0.9990) and magnoflorine and Menisperine were the major constituents in the barks of P. olacoides. The contents of magnoflorine and Menisperine accounted for 75.96% of all analytes. However, the content of phenolic components was smaller and the highest content was no more than 1.04 mg/g. Collectively, these results suggested that alkaloids are the dominant substances in P. olacoides, which can make a difference for the quality control and further use of P. olacoides.

CAS No.	25342-82-9	Price	$318 / 10mg
Catalog No.	CFN95318	Purity	>=98%
Molecular Weight	356.4	Type of Compound	Alkaloids
Formula	C₂₁H₂₆NO₄	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	Menisperine
CAS No.:	25342-82-9
Catalog No.:	CFN95318
Molecular Formula:	C₂₁H₂₆NO₄
Molecular Weight:	356.4 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Targets:	NF-魏B
Source:	The barks of Phellodendron chinense
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$318 / 10mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8058 mL	14.0292 mL	28.0584 mL	56.1167 mL	70.1459 mL
5 mM	0.5612 mL	2.8058 mL	5.6117 mL	11.2233 mL	14.0292 mL
10 mM	0.2806 mL	1.4029 mL	2.8058 mL	5.6117 mL	7.0146 mL
50 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.1223 mL	1.4029 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.5612 mL	0.7015 mL

CFN95337	Fuzitine	142287-96-5	342.4	C₂₀H₂₄NO₄
CFN90259	Magnoflorine chloride	6681-18-1	377.87	C₂₀H₂₄NO₄Cl
CFN97169	Xanthoplanine	6872-88-4	356.4	C₂₁H₂₆NO₄
CFN97205	Laurifoline	7224-61-5	342.4	C₂₀H₂₄NO₄
CFN95594	4-Keto-laurifoline	N/A	356.4	C₂₀H₂₂NO₅+
CFN98071	Magnoflorine	2141-09-5	342.4	C₂₀H₂₄NO₄
CFN95318	Menisperine	25342-82-9	356.4	C₂₁H₂₆NO₄
CFN92891	N-Methylcorydinium iodide	4668-64-6	356.43	C₂₁H₂₆NO₄
CFN92948	Trilobinine	126595-92-4	342.41	C₂₀H₂₄NO₄+