Methylpheophorbide A | CAS:5594-30-9 | Manufacturer ChemFaces

Methylpheophorbide A

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Methylphophorbide A shows antioxidative and anticarcinogenic activities.

In vitro:

Photodiagnosis Photodyn Ther. 2017 Mar;17:39-47.

Semi-synthesis and PDT activities of a new amphiphilic chlorin derivative.[Pubmed: 27769913]

An amphiphilic chlorin derivative (CHL-T) was prepared from Methylpheophorbide A (CHL) and 2-Amino-2-(hydroxymethyl)-1,3-propanediol (TRISMA®).
METHODS AND RESULTS:
The new chlorin was compared to other dyes (CHL and Hypericin) in relation to photophysical and photobiological activities in tumor and non-tumor cell lines. Cytotoxicity and cell death target were determined to evaluate the CHL-T efficiency, comparing to the precursor CHL and to the well-known dye hypericin (HY). All of the studied compounds exhibited absorption bands in the therapeutic window and presented a small fluorescence quantum yield compared to the reference dye (rhodamine B). CHL-T was about three times more efficient on singlet oxygen generation than the others photosensitizers. The lipophilicity order of the photosensitizers was CHL>HY>CHL-T. The tumoral HeLa cells presented improved accumulation for CHL and CHL-T compared to HY. The phototoxicity presented by the CHL-T was about ten times higher than by CHL, as demonstrated by the MTT assay. CHL-T showed more cytotoxicity to tumoral cell, comparing to non-tumoral cell in short incubation time. The cell death rises proportionally with increasing PSs concentrations, mainly by necrosis.
CONCLUSIONS:
These findings suggest that CHL-T is a potential new photosensitizer for PDT.

Nat Prod Res. 2016;30(4):474-7.

Antioxidative and anticarcinogenic activities of methylpheophorbide a, isolated from wheat grass (Triticum aestivum Linn.).[Pubmed: 25782530 ]

Methylphophorbide A (MPa) has been isolated from the ethanol extract of the wheat grass plant.
METHODS AND RESULTS:
Its antioxidative efficacy is evaluated by hydroxyl radical scavenging activities and reducing capacity which are significantly up regulated in comparison with aqueous extract of the plant. The compound shows iron-binding capacity where the Fe(2+) binds with MPa by two types of binding patterns with dissociation constants 157.17 and 27.89. It has antioxidative and cytotoxic effects on HeLa and Hep G2 cells. The cancerous cell survivability decreases with increasing concentration of MPa.
CONCLUSIONS:
These findings have provided evidence for the traditional use of the wheat grass plant in the treatment of cancers, oxidative stress and iron overloaded disorders.

Methylpheophorbide A Description

Source:	The herbs of Rubia cordifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Methylpheophorbide A
Price:
CAS No.:	5594-30-9
Catalog No.:	CFN91976
Molecular Formula:	C₃₆H₃₈N₄O₅
Molecular Weight:	606.71 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Rubia cordifolia
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6482 mL	8.2412 mL	16.4823 mL	32.9647 mL	41.2058 mL
5 mM	0.3296 mL	1.6482 mL	3.2965 mL	6.5929 mL	8.2412 mL
10 mM	0.1648 mL	0.8241 mL	1.6482 mL	3.2965 mL	4.1206 mL
50 mM	0.033 mL	0.1648 mL	0.3296 mL	0.6593 mL	0.8241 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.3296 mL	0.4121 mL

CFN92604	RA VII	86229-97-2	770.9	C₄₁H₅₀N₆O₉
CFN92605	RA-V	64725-24-2	756.9	C₄₀H₄₈N₆O₉
CFN92606	RA-XI	143277-27-4	814.9	C₄₂H₅₀N₆O₁₁
CFN97902	Enniatin B	917-13-5	639.8	C₃₃H₅₇N₃O₉
CFN97986	Enniatin B1	19914-20-6	653.9	C₃₄H₅₉N₃O₉
CFN91976	Methylpheophorbide A	5594-30-9	606.71	C₃₆H₃₈N₄O₅
CFN98204	Cytochalasin D	22144-77-0	507.6	C₃₀H₃₇NO₆
CFN70315	Cytochalasin C	22144-76-9	507.6	C₃₀H₃₇NO₆
CFN96781	Cytochalasin B	14930-96-2	479.61	C₂₉H₃₇NO₅