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2. Pharmacological research
3. Inhibitors
Micromelin
Citing Use of our Products
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / Inquiry |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
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Micromelin
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Archives of Biological sciences2022, 00:21-21Appl. Sci.2020, 10(16),5482.Applied Biological Chemistry2021, 64(4)Inflammation.2015, 38(4):1502-16Phytomedicine.2018, 41:62-66Eur J Pharmacol.2022, 917:174744.Cytotechnology2022, s10616Key Engineering Materials2022, 931(47-53).J Pharmaceutical and Biomedical Analysis2022, 114631.Biomolecules2021, 11(10),1513.
Related Screening Libraries
| Description: |
Micromelin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100.
|
| In vitro: |
| J Nat Prod. 1979 May-Jun;42(3):274-8. | | An investigation of the antitumor activity of Micromelum integerrimum (Rutaceae).[Pubmed: 490172] | Extracts of Micromelum integerrimum (Buch.-Ham. ex Coleb.) M. Roem. were fractionated based on in vivo activity in mice in the P-388 lymphocytic leukemia system.
METHODS AND RESULTS:
Activity in ethanol extracts was concentrated in the chloroform partition fraction, which was further resolved by chromatography on silica gel. The known coumarins, Micromelin and scopoletin, were crystallized from the active fractions and demonstrated to have antitumor activities. Micromelin was converted to the corresponding butenolide (deoxyMicromelin) which was inactive in the 9KB assay. |
|
Micromelin Description
| Source: |
The herbs of Micromelum integerrimum |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
3.4686 mL |
17.343 mL |
34.6861 mL |
69.3722 mL |
86.7152 mL |
| 5 mM |
0.6937 mL |
3.4686 mL |
6.9372 mL |
13.8744 mL |
17.343 mL |
| 10 mM |
0.3469 mL |
1.7343 mL |
3.4686 mL |
6.9372 mL |
8.6715 mL |
| 50 mM |
0.0694 mL |
0.3469 mL |
0.6937 mL |
1.3874 mL |
1.7343 mL |
| 100 mM |
0.0347 mL |
0.1734 mL |
0.3469 mL |
0.6937 mL |
0.8672 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Acta Crystallogr Sect E Struct Rep Online. 2011 Jul 1;67(Pt 7):o1706-7. | | Absolute configuration of micromelin.[Pubmed: 21837101] |
METHODS AND RESULTS:
The title compound Micromelin{systematic name: 7-meth-oxy-6-[(1R,2R,5R)-5-methyl-4-oxo-3,6-dioxabicyclo-[3.1.0]hexan-2-yl]-2H-chromen-2-one}, C(15)H(12)O(6), is a coumarin, which was isolated from the roots of Micromelum glanduliferum. There are two mol-ecules in the asymmetric unit with slight differences in bond angles. In both mol-ecules, the furan ring adopts a flattened envelope conformation. In the crystal, mol-ecules are linked by weak C-H⋯O inter-actions into chains along the a axis. Aromatic π-π stacking inter-actions with centroid-centroid distances in the range 3.6995 (11)-3.8069 (11) Å and C⋯O short contacts [3.030 (2)-3.171 (3) Å] also occur. | | Arch Pharm Res. 2011 Apr;34(4):527-31. | | C-7 oxygenated coumarins from the fruits of Micromelum minutum.[Pubmed: 21544717] |
METHODS AND RESULTS:
A new 7-oxygenated coumarin, 7-demethylmurralonginol isovalerate (1), and a new natural product, murralonginol (2), together with seven known 7-oxygenated coumarins, murralonginol isovalerate (3), murralongin (4), Micromelin (5), scopoletin (6), microminutin (7), murrangatin (8), and minumicrolin (9), were isolated from the fruits of Micromelum minutum. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data.
CONCLUSIONS:
Among these isolates, compounds 2 and 4 - 9 exhibited cytotoxicity against cholangiocarcinoma cell line, KKU-100. |
|
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