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    Natural Products
    Monomethylsulochrin
    Monomethylsulochrin
    Information
    CAS No. 10056-14-1 Price
    Catalog No.CFN96952Purity>=98%
    Molecular Weight346.33Type of CompoundPhenols
    FormulaC18H18O7Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    * Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
    Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
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    Monomethylsulochrin

    Monomethylsulochrin
    Product Name Monomethylsulochrin
    CAS No.: 10056-14-1
    Catalog No.: CFN96952
    Molecular Formula: C18H18O7
    Molecular Weight: 346.33 g/mol
    Purity: >=98%
    Type of Compound: Phenols
    Physical Desc.: Powder
    Targets: Antifection
    Source: The cultures of a marine-derived fungus Aspergillus sp. B-F-2.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price:
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  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Antibacterial Compound Library
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  • Biological Activity
    Description: Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
    Targets: Antifection
    In vitro:
    Chem Biodivers. 2010 Jan;7(1):216-20.
    Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis.[Pubmed: 20087992 ]

    METHODS AND RESULTS:
    The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, Monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated.
    CONCLUSIONS:
    Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively.
    J Antibiot (Tokyo). 2006 Jun;59(6):362-5.
    A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2.[Pubmed: 16915822 ]

    METHODS AND RESULTS:
    A new diphenyl ether dimethyl 2,3'-dimethylosoate (1) together with three known compounds Monomethylsulochrin (2), emodin (3), and questin (4) were isolated through bioassay-guided fractionations from the culture of a marine-derived fungus Aspergillus sp. B-F-2.
    CONCLUSIONS:
    The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds 1 and 2 against K562 cell line were preliminarily evaluated by the MTT method and flow cytometry.
    Monomethylsulochrin Description
    Source: The cultures of a marine-derived fungus Aspergillus sp. B-F-2.
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8874 mL 14.4371 mL 28.8742 mL 57.7484 mL 72.1855 mL
    5 mM 0.5775 mL 2.8874 mL 5.7748 mL 11.5497 mL 14.4371 mL
    10 mM 0.2887 mL 1.4437 mL 2.8874 mL 5.7748 mL 7.2185 mL
    50 mM 0.0577 mL 0.2887 mL 0.5775 mL 1.155 mL 1.4437 mL
    100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.5775 mL 0.7219 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    An Acad Bras Cienc. 2013;85(4):1247-53.
    Chemical constituents of Aspergillus sp EJC08 isolated as endophyte from Bauhinia guianensis and their antimicrobial activity.[Pubmed: 24141408 ]
    The present work reports the isolation of five compounds from Aspergillus sp EJC08 isolated as endophytic from Bauhinia guianensis, a tipical plant of the Amazon.
    METHODS AND RESULTS:
    The compounds ergosterol (1), ergosterol peroxide (2), mevalolactone (3), Monomethylsulochrin (4) and trypacidin A (5) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS.
    CONCLUSIONS:
    Compounds 3, 4 and 5 were tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus and showed good activity.
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