N-Feruloyloctopamine | CAS:66648-44-0 | Manufacturer ChemFaces

N-Feruloyloctopamine

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $148.1 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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In vitro:

Bioorg Med Chem Lett . 2017 Feb 15;27(4):989-993.

Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells[Pubmed: 28073674]

Abstract N-trans-feruloyloctopamine (FO) isolated from Garlic skin was identified as the primary antioxidant constituents, however, the effect of which on HCC invasion is still unclear. Herein, the FO was synthesized and its antitumor activities were evaluated in HCC cell lines. Cellular functional analyses have revealed that the reformed FO owns strong abilities of inhibiting cell proliferation and invasion in HCC cells. Molecular data have further showed that FO could significantly decrease the phosphorylation levels of Akt and p38 MAPK. In addition, the expression of Slug was inhibited and the level of E-cadherin increased. Molecular docking analysis indicates that the H-bond and hydrophobic interactions were critical for FO and E-cadherin binding, but FO did not seem to act directly on phosphorylated Akt and p38 MAPK. We have thus concluded that reformed FO inhibits cell invasion might be directly through EMT related signals (E-cadherin) and indirectly through PI3K/Akt, p38 MAPK signaling pathways. FO might be a promising drug in HCC treatment and prognosis. Keywords: AKT; E-cadherin; Epithelial to mesenchymal transition (EMT); Hepatocellular carcinoma; MAPK; N-trans-feruloyloctopamine (FO).

N-Feruloyloctopamine Description

Source:	The herbs of Datura arborea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Plant Cell Physiol. 2005 Mar;46(3):454-66.

Metabolic flux analysis of the phenylpropanoid pathway in elicitor-treated potato tuber tissue.[Pubmed: 15695456]

The effects of beta-1,3-oligosaccharide elicitor on the metabolism of phenylpropanoids in potato tuber were analyzed quantitatively, by monitoring the time-dependent changes in the levels of seven compounds.
METHODS AND RESULTS:
The elicitor treatment caused an increase in the pool size of octopamine and tyramine amides (N-p-coumaroyloctopamine, N-Feruloyloctopamine, N-p-coumaroyltyramine and N-feruloyltyramine), as well as a decrease in that of chlorogenic acid and putrescine amides (caffeoylputrescine and feruloylputrescine). An analysis of metabolic flux using stable isotope labeling and liquid chromatography-spectrometry (LC-MS) detection clearly demonstrated that the changes in the pool size of these compounds were correlated with the changes in their flux for biosynthesis (Jin) upon elicitor treatment. The increase in Jin in the cases of octopamine and tyramine amides was accompanied by an increase in flux for the transformation (Jout), indicating a rapid turnover of these compounds in the elicitor-treated tuber tissue. The result of the flux analysis indicated that the actual activation of the biosynthesis of octopamine and tyramine amides after the elicitor treatment was greater than that estimated from the changes in their levels in the potato tissue.
CONCLUSIONS:
These findings suggest that these amide compounds and their metabolic derivatives play an important role in the defense-related metabolism of phenylpropanoids in potato.

Product Name	N-Feruloyloctopamine
Price:	$338 / 10mg
CAS No.:	66648-44-0
Catalog No.:	CFN97707
Molecular Formula:	C₁₈H₁₉NO₅
Molecular Weight:	329.35 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Datura arborea
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Inhibitors Compound Library Antibacterial Compound Library Antifungal Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0363 mL	15.1814 mL	30.3628 mL	60.7257 mL	75.9071 mL
5 mM	0.6073 mL	3.0363 mL	6.0726 mL	12.1451 mL	15.1814 mL
10 mM	0.3036 mL	1.5181 mL	3.0363 mL	6.0726 mL	7.5907 mL
50 mM	0.0607 mL	0.3036 mL	0.6073 mL	1.2145 mL	1.5181 mL
100 mM	0.0304 mL	0.1518 mL	0.3036 mL	0.6073 mL	0.7591 mL

CFN94001	Cannabisin H	403647-08-5	509.55	C₂₈H₃₁NO₈
CFN93215	Kukoamine A	75288-96-9	530.7	C₂₈H₄₂N₄O₆
CFN93216	Kukoamine B	164991-67-7	530.7	C₂₈H₄₂N₄O₆
CFN98937	Asperglaucide	56121-42-7	444.5	C₂₇H₂₈N₂O₄
CFN98984	Aurantiamide	58115-31-4	402.5	C₂₅H₂₆N₂O₃
CFN91929	Aurantiamide benzoate	150881-02-0	506.59	C₃₂H₃₀N₂O₄
CFN95268	Cannabisin B	144506-17-2	596.6	C₃₄H₃₂N₂O₈
CFN90405	Cannabisin D	144506-19-4	624.69	C₃₆H₃₆N₂O₈
CFN95456	Cannabisin P	2756983-19-2	614.7	C₃₄H₃₄N₂O₉
CFN95436	Cannabisin M	1831134-13-4	596.6	C₃₄H₃₂N₂O₈