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1. Reference standards
2. Pharmacological research
3. Inhibitors
Neoorthosiphol A
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $251.2 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Med Sci Monit.2019, 25:9499-9508J Biochem Mol Toxicol....2020...Int J Mol Sci.2021, 22(9):5012.Antioxidants (Basel).2020, 9(6):466.Am J Chin Med.2015, 30:1-22Biochem Systematics and Ecology...2017...Current Pharmaceutical Analysis...2017...Appl. Sci. 2021, 11(8),3437.
Toxins (Basel).2020, 12(4):210. RSC Adv.2018, 32621-32636Int J Mol Sci.2020, 21(9):3392. Preprints2017, 2017120176Biofactors.2018, 44(2):168-179Molecules.2018, 23(9):E2121Cell Death Dis.2019, 10(12):882Enzyme and Microbial Technology...2022...
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Our products had been exported to the following research institutions and universities, And still growing.
The Institute of Cancer Research (United Kingdom)Universidade da Beira Interior (Germany)The Ohio State University (USA)University of Perugia (Italy)
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Universidade Federal de Santa C... (Brazil)Florida International University (USA)Universidad Industrial de Santa... (Colombia)
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Neoorthosiphol A
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manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Environ Toxicol.2022, 37(3):514-526.Exp Ther Med.2019, 18(6):4388-4396Nutrients.2021, 13(1):254. Korean Journal of Pharmacognosy2018, 49(1):76-83Anal Bioanal Chem.2018, 410(5):1561-1569Microb Biotechnol.2021, 14(5):2009-2024.Toxicol In Vitro.2018, 52:94-105Evid Based Complement Alternat Med.2018, 2018:1073509Molecules.2015, 20(10):19172-88Evid Based Complement Alternat Med.2018, 2018:4580627
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Diterpenoids Compound Library |
| Description: |
Neoorthosiphol A inhibits rat thoracic aortic systolic response. Neoorthosiphol A shows antiprolifer-ative activity against highly hepatic metastatic colon 26-L5 carcinoma and the human HT-1080 fibrosarcoma cell line. |
| In vitro: |
| Chem Pharm Bull (Tokyo) . 2003 Mar;51(3):268-275. | | Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity[Pubmed: 12612410] | | From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)]. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC(50), 10.8-25.5 microM) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 26.0 microM). | | J Nat Prod . 2001 May;64(5):592-596. | | Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar[Pubmed: 11374950] | | Five novel highly oxygenated diterpenes, orthosiphols K (1), L (2), M (3), and N (4) and norstaminone A (5), were isolated from the aerial part of Orthosiphon stamineus, together with three known diterpenes, orthosiphols A (6) and B (7) and Neoorthosiphol A (8). Orthosiphol L (2) is an isopimarane-type diterpene with a hydroxyl group at C-12, which supports the biogenesis of staminane-type diterpenes, i.e., migration of a vinylic group from C-13 of isopimarane to C-12. Norstaminone A (5) has a staminane carbon framework and supports the biosynthetic pathway from staminols to norstaminols via staminolactones. All the isolated compounds showed mild to weak antiproliferative activities toward highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines. |
|
| In vivo: |
| Chem Pharm Bull (Tokyo). 2000 Mar;48(3):433-435. | | Indonesian medicinal plants. XXIII. Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae)[Pubmed: 10726872] | | Two novel migrated pimarane-type diterpenes named neoorthosiphols A (1) and B (2) were isolated from the water decoction of the leaves of Orthosiphon aristatus (Lamiaceae), which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension, etc. The absolute chemical structures have been elucidated on the basis of physicochemical properties. It has been found that two migrated pimarane-type diterpenes (1, 2), four isopimarane-type diterpenes (3, 4, 5, 6), three benzochromenes (7, 8, 9) and two flavones (12, 13) exhibit a suppressive effect on contractile responses in rat thoracic aorta, among thirteen chemical constituents (1-13) isolated from the leaves. |
|
Neoorthosiphol A Description
| Source: |
The branches of Platycladus orientalis |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.4434 mL |
7.2171 mL |
14.4342 mL |
28.8684 mL |
36.0855 mL |
| 5 mM |
0.2887 mL |
1.4434 mL |
2.8868 mL |
5.7737 mL |
7.2171 mL |
| 10 mM |
0.1443 mL |
0.7217 mL |
1.4434 mL |
2.8868 mL |
3.6085 mL |
| 50 mM |
0.0289 mL |
0.1443 mL |
0.2887 mL |
0.5774 mL |
0.7217 mL |
| 100 mM |
0.0144 mL |
0.0722 mL |
0.1443 mL |
0.2887 mL |
0.3609 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Chem Pharm Bull (Tokyo). 2000 Mar;48(3):433-435. | | Indonesian medicinal plants. XXIII. Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae)[Pubmed: 10726872] | | Two novel migrated pimarane-type diterpenes named neoorthosiphols A (1) and B (2) were isolated from the water decoction of the leaves of Orthosiphon aristatus (Lamiaceae), which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension, etc. The absolute chemical structures have been elucidated on the basis of physicochemical properties. It has been found that two migrated pimarane-type diterpenes (1, 2), four isopimarane-type diterpenes (3, 4, 5, 6), three benzochromenes (7, 8, 9) and two flavones (12, 13) exhibit a suppressive effect on contractile responses in rat thoracic aorta, among thirteen chemical constituents (1-13) isolated from the leaves. |
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