Neoorthosiphol A | CAS:243448-72-8 | Manufacturer ChemFaces

Neoorthosiphol A

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Description:

Neoorthosiphol A inhibits rat thoracic aortic systolic response. Neoorthosiphol A shows antiprolifer-ative activity against highly hepatic metastatic colon 26-L5 carcinoma and the human HT-1080 fibrosarcoma cell line.

In vitro:

Chem Pharm Bull (Tokyo) . 2003 Mar;51(3):268-275.

Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity[Pubmed: 12612410]

From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)]. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC(50), 10.8-25.5 microM) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 26.0 microM).

J Nat Prod . 2001 May;64(5):592-596.

Five novel highly oxygenated diterpenes of Orthosiphon stamineus from Myanmar[Pubmed: 11374950]

Five novel highly oxygenated diterpenes, orthosiphols K (1), L (2), M (3), and N (4) and norstaminone A (5), were isolated from the aerial part of Orthosiphon stamineus, together with three known diterpenes, orthosiphols A (6) and B (7) and Neoorthosiphol A (8). Orthosiphol L (2) is an isopimarane-type diterpene with a hydroxyl group at C-12, which supports the biogenesis of staminane-type diterpenes, i.e., migration of a vinylic group from C-13 of isopimarane to C-12. Norstaminone A (5) has a staminane carbon framework and supports the biosynthetic pathway from staminols to norstaminols via staminolactones. All the isolated compounds showed mild to weak antiproliferative activities toward highly liver metastatic colon 26-L5 carcinoma and human HT-1080 fibrosarcoma cell lines.

In vivo:

Chem Pharm Bull (Tokyo). 2000 Mar;48(3):433-435.

Indonesian medicinal plants. XXIII. Chemical structures of two new migrated pimarane-type diterpenes, neoorthosiphols A and B, and suppressive effects on rat thoracic aorta of chemical constituents isolated from the leaves of Orthosiphon aristatus (Lamiaceae)[Pubmed: 10726872]

Two novel migrated pimarane-type diterpenes named neoorthosiphols A (1) and B (2) were isolated from the water decoction of the leaves of Orthosiphon aristatus (Lamiaceae), which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension, etc. The absolute chemical structures have been elucidated on the basis of physicochemical properties. It has been found that two migrated pimarane-type diterpenes (1, 2), four isopimarane-type diterpenes (3, 4, 5, 6), three benzochromenes (7, 8, 9) and two flavones (12, 13) exhibit a suppressive effect on contractile responses in rat thoracic aorta, among thirteen chemical constituents (1-13) isolated from the leaves.

Neoorthosiphol A Description

Source:	The branches of Platycladus orientalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Chem Pharm Bull (Tokyo). 2000 Mar;48(3):433-435.

CAS No.	243448-72-8	Price	$318 / 10mg
Catalog No.	CFN95447	Purity	>=98%
Molecular Weight	692.8	Type of Compound	Diterpenoids
Formula	C₃₈H₄₄O₁₂	Physical Description	Powder
Download		Similar structural	Comparison (Web) (SDF)

Product Name	Neoorthosiphol A
CAS No.:	243448-72-8
Catalog No.:	CFN95447
Molecular Formula:	C₃₈H₄₄O₁₂
Molecular Weight:	692.8 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The branches of Platycladus orientalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$318 / 10mg

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4434 mL	7.2171 mL	14.4342 mL	28.8684 mL	36.0855 mL
5 mM	0.2887 mL	1.4434 mL	2.8868 mL	5.7737 mL	7.2171 mL
10 mM	0.1443 mL	0.7217 mL	1.4434 mL	2.8868 mL	3.6085 mL
50 mM	0.0289 mL	0.1443 mL	0.2887 mL	0.5774 mL	0.7217 mL
100 mM	0.0144 mL	0.0722 mL	0.1443 mL	0.2887 mL	0.3609 mL

CFN92876	Hugorosenone	217096-49-6	302.4	C₂₀H₃₀O₂
CFN96300	Yucalexin P-17	119642-82-9	318.5	C₂₀H₃₀O₃
CFN90861	Continentalic acid	19889-23-7	302.5	C₂₀H₃₀O₂
CFN99382	Pimaric acid	127-27-5	302.5	C₂₀H₃₀O₂
CFN97723	Isopimaric acid	5835-26-7	302.46	C₂₀H₃₀O₂
CFN98805	Rosenonolactone	508-71-4	316.4	C₂₀H₂₈O₃
CFN95442	Orthosiphol A	142741-25-1	676.8	C₃₈H₄₄O₁₁
CFN95447	Neoorthosiphol A	243448-72-8	692.8	C₃₈H₄₄O₁₂
CFN97214	15-Isopimarene-8,18-diol	73002-86-5	306.5	C₂₀H₃₄O₂
CFN92899	Toonaciliatin M	93930-04-2	320.47	C₂₀H₃₂O₃