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Onitisin
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Product Name Onitisin
Price:
CAS No.: 53823-03-3
Catalog No.: CFN98899
Molecular Formula: C15H20O4
Molecular Weight: 264.3 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Powder
Source: The herbs of Onychium japonicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Onitisin, onitinoside and onitin can inhibit the contraction of isolated guinea-pig ileum.
Targets: 5-HT Receptor
In vitro:
Planta Medica, 1985 ,51 (2) :148-50.
Studies on the Taiwan folk medicine; III. A smooth muscle relaxant from Onychium siliculosum, onitin[Reference: WebLink]

METHODS AND RESULTS:
The pharmacological properties of onitin, onitinoside and Onitisin, three phenolic pterosins, isolated from Onychium siliculosum have been investigated. Their predominant effects are to inhibit the contraction of isolated guinea-pig ileum. In these three compounds, onitin is the most potent one.
CONCLUSIONS:
Onitin (1 × 10-4M) inhibits both the D receptor and M receptor of 5-HT. The antagonism of onitin against histamine is non-competitive.
Onitisin Description
Source: The herbs of Onychium japonicum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7836 mL 18.9179 mL 37.8358 mL 75.6716 mL 94.5895 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL 15.1343 mL 18.9179 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL 7.5672 mL 9.4589 mL
50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.5134 mL 1.8918 mL
100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7567 mL 0.9459 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):946-50.
Sesquiterpenoids of Coniogramme maxima.[Pubmed: 22792795]

METHODS AND RESULTS:
Fifteen compounds were separated by chromatography technique. Their structures were determined by spectral data, including 10 sesquiterpenoids as (3S)-pteroside D (1), epi-pterosin L (2), pterosin D (3), onitin (4), pterosin Z (5), Onitisin (6), Onitisin-glucopyranoside (7), onitin-15-O-beta-D-glucopyranoside (8), (2S,3R)-pterosin-L-2'-O-beta-D-glucopyranoside (9) and (3R)-peterosin D-3-O-beta-D-glucopyranoside (10). The other compounds were uracil (11), 3,4-dihydroxybenzaldehyde (12), 5-hydroxymethyl-2-furancarboxaldehyde (13), beta-sitosterol (14) and daucosterol (15).
CONCLUSIONS:
The above 15 compounds are separated from C. maxima for the first time, including 9 compounds being first separated from genus Coniogramme.
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Kaempferide

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