ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
3. Inhibitors
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: info@chemfaces.com
Contact Us
Order & Inquiry & Tech Support
Tel: (0086)-27-84237683
Fax: (0086)-27-84254680
E-mail: manager@chemfaces.com
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery time
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock |
10 mM * 1 mL in DMSO / $67.5 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
J Microbiol Biotechnol....2020...Molecules.2021, 26(4):1084.Phytother Res.2019, 33(5):1490-1500Journal of Third Military Medical...2019...Antioxidants (Basel).2022, 11(1):171.Curr Res Virol Sci.2022, 3:100019.Food Analytical Methods2020, 1-10Neuropharmacology2019, 151437
Applied Biological Chemistry...2022...Plants (Basel).2021, 10(6):1119.J Ethnopharmacol.2017, 196:75-83Biomed Pharmacother.2021, 139:111585. Medicinal Chemistry Research ...2021...LWT - Food Science and Technology...2022...Separation Science Plus...2022...Industrial Crops and Products...2021...
Plant Sci.2020, 301:110656.J Agric Food Chem....2020...Theoretical and Experimental Plan...2022...Int. J. Mol. Sci. 2022, 23(3),1696.J Enzyme Inhib Med Chem....2019...Biomed Chromatogr.2022, 36(11):e5462.Biomed Chromatogr.2016, 30(10):1573-81
More...
Our products had been exported to the following research institutions and universities, And still growing.
University of Zurich (Switzerland)University of Mysore (India)Chinese University of Hong Kong (China)Universite Libre de Bruxelles (Belgium)
Tokyo Woman's Christian University (Japan)Seoul National University of Sc... (Korea)Seoul National University (Korea)Universita' Degli Studi Di Cagl... (Italy)
Stanford University (USA)Leibniz Institute of Plant Bioc... (Germany)Institute of Tropical Disease U... (Indonesia)
More...
Paulownin
Inquire / Order:
manager@chemfaces.com
Technical Inquiries:
service@chemfaces.com
Tel:
+86-27-84237783
Fax:
+86-27-84254680
Address:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Curr Issues Mol Biol.2022, 44(10):5106-5116.In Vivo.2022, 36(3):1136-1143. Separations2021, 8(6),80.Medicinal Chemistry Research 2021, 30:1117-1124.Phytochem Anal.2022, doi: 10.1002US20170000760 A12016, 42740Foods.2022, 11(12):1708.Biorxiv.2020, doi: 10.1101.J Chromatogr Sci.2020, 58(6):485-493.Planta Med.2019, 85(4):347-355
Related Screening Libraries
Description: |
Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. Paulownin demonstrates inhibitory activities against H. pylori Cystathionine gamma- synthase (HpCGS) with IC50 values of 19 +/- 2 microM, it can highly inhibit the growth of H. pylori and exhibit strong inhibitory specificity against H. pylori related to E. coli. (+)-Paulownin is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM. |
Targets: |
Antifection |
In vitro: |
Nat Prod Commun. 2012 Oct;7(10):1333-6. | Two new naphthoquinone derivatives from the stem bark of Callicarpa maingayi.[Pubmed: 23157003] | METHODS AND RESULTS: Two new naphthoquinones designated as 3alpha-hydroxy-2-(2-hydroxypropan-2-yI)-9alpha-methoxy-2,3,3alpha,9alpha-tetra-hydronaphtho[2,3-b]furan-4,9-dione (callicarpa-quinone A, 1) and 5-hydroxy-2-(2-hydroxypropan-2-yl)naphtho[2,3-b]furan-4,9-dione (callicarpaquinone B, 2) were isolated from the chloroform fraction of Callicarpa maingayi. Three other known compounds, identified as avicequinone-C (3), wodeshiol (4) and Paulownin (5), were reported for the first time from this species. The structure elucidation of compounds was established by comprehensive 1D and 2D NMR spectroscopic analyses as well as EIMS, UV and IR spectral data. Compounds 1 and 2 were tested in vitro for their cytotoxic activity against human breast cancer MCF-7cells.
CONCLUSIONS:
Compound 2 exhibited strong cytotoxic activity with an IC50 value of 1.9 +/- 0.2 microM, while 1 showed moderate activity with an IC50 value of 25.0 +/- 4.3 microM. | J Biochem. 2008 Jan;143(1):59-68. | Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori.[Pubmed: 17981822] |
Cystathionine gamma-synthase (CGS) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human.
METHODS AND RESULTS:
In this report, we identified a new metB gene from Helicobacter pylori strain SS1, and the recombinant H. pylori Cystathionine gamma-synthase (HpCGS) was successfully cloned, expressed and purified in Escherichia coli system. Enzymatic study of HpCGS indicated that the K(m) and k(cat)/K(m) values against the substrate O-succinyl-l-homoserine (l-OSHS) were 3.02 mM and 98.7 M(-)(1)s(-)(1), respectively. Moreover, four natural products (alpha-lapachone, 9-hydroxy-alpha-lapachone, Paulownin and Yangambin, Fig. 1) were discovered to demonstrate inhibitory activities against HpCGS with IC(50) values of 11 +/- 3, 9 +/- 1, 19 +/- 2 and 27 +/- 6 microM, respectively. CONCLUSIONS: All these four inhibitors prevent the binding of l-OSHS to HpCGS in a non-competitive fashion.
In vitro antibacterial assays further indicated that these four discovered compounds could highly inhibit the growth of H. pylori and exhibited strong inhibitory specificity against H. pylori related to E. coli. |
|
In vivo: |
Guangxi Sciences, 2007, 14(4):405-6. | The Experiment Studies on Pharmcological Action of Paulownin[Reference: WebLink] | To observe the anti-inflammation,analgesia,immunite,hypoglycemia action of Paulownin.
METHODS AND RESULTS:
Used the methods of ear swelling cused by xylene,acetic acid twisting,carbon expurgation and the hyperglycemia induced by glucose,to observe the pharmcological action of Paulownin;and acute toxicity was observed.Paulownin in high does could inhibit significantly ear swelling induced by xylene,high and low does could decrease body twisting times induced by acetice,and Paulownin in high and low does could increase the phagocytic funtion of mononu clear phagocyte;Paulownin in high dose could obviously decrease blood glucose,and low dose had the action on hypoglycemia in hyperglycemia mice induced by glucose.
CONCLUSIONS:
The acute toxicity test of Paulownin showed that its maximum tolerance is 4.5g/kg in mice.Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. |
|
Paulownin Description
Source: |
The barks of Paulownia tomentosa |
Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
2.6998 mL |
13.4989 mL |
26.9978 mL |
53.9957 mL |
67.4946 mL |
5 mM |
0.54 mL |
2.6998 mL |
5.3996 mL |
10.7991 mL |
13.4989 mL |
10 mM |
0.27 mL |
1.3499 mL |
2.6998 mL |
5.3996 mL |
6.7495 mL |
50 mM |
0.054 mL |
0.27 mL |
0.54 mL |
1.0799 mL |
1.3499 mL |
100 mM |
0.027 mL |
0.135 mL |
0.27 mL |
0.54 mL |
0.6749 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Structure Identification: |
Planta Med. 2011 Jun;77(9):951-4. | Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum.[Pubmed: 21243588] | METHODS AND RESULTS:
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and Paulownin.
CONCLUSIONS:
The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities. |
|
Tags: buy Paulownin | Paulownin supplier | purchase Paulownin | Paulownin cost | Paulownin manufacturer | order Paulownin | Paulownin distributor