Paulownin | CAS:13040-46-5 | Manufacturer ChemFaces

Paulownin

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Size /Price /Stock	10 mM * 1 mL in DMSO / $67.5 / In-stock
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Description:

Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity. Paulownin demonstrates inhibitory activities against H. pylori Cystathionine gamma- synthase (HpCGS) with IC50 values of 19 +/- 2 microM, it can highly inhibit the growth of H. pylori and exhibit strong inhibitory specificity against H. pylori related to E. coli. (+)-Paulownin is active against the MCF-7 breast cancer cell line with IC50 values of 14.0 uM.

Targets:

Antifection

In vitro:

Nat Prod Commun. 2012 Oct;7(10):1333-6.

Two new naphthoquinone derivatives from the stem bark of Callicarpa maingayi.[Pubmed: 23157003]

METHODS AND RESULTS:
Two new naphthoquinones designated as 3alpha-hydroxy-2-(2-hydroxypropan-2-yI)-9alpha-methoxy-2,3,3alpha,9alpha-tetra-hydronaphtho[2,3-b]furan-4,9-dione (callicarpa-quinone A, 1) and 5-hydroxy-2-(2-hydroxypropan-2-yl)naphtho[2,3-b]furan-4,9-dione (callicarpaquinone B, 2) were isolated from the chloroform fraction of Callicarpa maingayi. Three other known compounds, identified as avicequinone-C (3), wodeshiol (4) and Paulownin (5), were reported for the first time from this species. The structure elucidation of compounds was established by comprehensive 1D and 2D NMR spectroscopic analyses as well as EIMS, UV and IR spectral data. Compounds 1 and 2 were tested in vitro for their cytotoxic activity against human breast cancer MCF-7cells.
CONCLUSIONS:
Compound 2 exhibited strong cytotoxic activity with an IC50 value of 1.9 +/- 0.2 microM, while 1 showed moderate activity with an IC50 value of 25.0 +/- 4.3 microM.

J Biochem. 2008 Jan;143(1):59-68.

Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori.[Pubmed: 17981822]

Cystathionine gamma-synthase (CGS) catalyses the first step of the transsulfuration pathway that converts l-cysteine to l-homocysteine in bacteria, whereas this pathway is absent in human.
METHODS AND RESULTS:
In this report, we identified a new metB gene from Helicobacter pylori strain SS1, and the recombinant H. pylori Cystathionine gamma-synthase (HpCGS) was successfully cloned, expressed and purified in Escherichia coli system. Enzymatic study of HpCGS indicated that the K(m) and k(cat)/K(m) values against the substrate O-succinyl-l-homoserine (l-OSHS) were 3.02 mM and 98.7 M(-)(1)s(-)(1), respectively. Moreover, four natural products (alpha-lapachone, 9-hydroxy-alpha-lapachone, Paulownin and Yangambin, Fig. 1) were discovered to demonstrate inhibitory activities against HpCGS with IC(50) values of 11 +/- 3, 9 +/- 1, 19 +/- 2 and 27 +/- 6 microM, respectively.
CONCLUSIONS:
All these four inhibitors prevent the binding of l-OSHS to HpCGS in a non-competitive fashion. In vitro antibacterial assays further indicated that these four discovered compounds could highly inhibit the growth of H. pylori and exhibited strong inhibitory specificity against H. pylori related to E. coli.

In vivo:

Guangxi Sciences, 2007, 14(4):405-6.

The Experiment Studies on Pharmcological Action of Paulownin[Reference: WebLink]

To observe the anti-inflammation,analgesia,immunite,hypoglycemia action of Paulownin.
METHODS AND RESULTS:
Used the methods of ear swelling cused by xylene,acetic acid twisting,carbon expurgation and the hyperglycemia induced by glucose,to observe the pharmcological action of Paulownin;and acute toxicity was observed.Paulownin in high does could inhibit significantly ear swelling induced by xylene,high and low does could decrease body twisting times induced by acetice,and Paulownin in high and low does could increase the phagocytic funtion of mononu clear phagocyte;Paulownin in high dose could obviously decrease blood glucose,and low dose had the action on hypoglycemia in hyperglycemia mice induced by glucose.
CONCLUSIONS:
The acute toxicity test of Paulownin showed that its maximum tolerance is 4.5g/kg in mice.Paulownin has the action of anti-inflammation,analgesia,immunity,hypoglycemia and has little toxicity.

Paulownin Description

Source:	The barks of Paulownia tomentosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Planta Med. 2011 Jun;77(9):951-4.

Lignans and other constituents from the roots of the Vietnamese medicinal plant Pseuderanthemum palatiferum.[Pubmed: 21243588]

METHODS AND RESULTS:
Two new lignans, palatiferin A (1) and palatiferin B (2), were isolated from the roots of Pseuderanthemum palatiferum, together with five known triterpenes, epifriedelanol (3), lupeol (4), lupenone (5), betulin (6), pomolic acid (7), and a dipeptide asperglaucide (8). Their structures were established from 2D NMR and mass spectroscopy. The absolute configuration of 1 and 2 was proposed based on the comparison of their optical rotation activities with those of compounds with similar structures such as wodeshiol and Paulownin.
CONCLUSIONS:
The new lignans, palatiferin A (1) and palatiferin B (2) exhibited a moderate cytotoxicity against KB and HepG2 cell lines. However, betulin and lupeol, two abundant compounds from the roots of P. palatiferum, showed cytotoxic and antimicrobial activities.

CAS No.	13040-46-5	Price	$188 / 20mg
Catalog No.	CFN99394	Purity	>=98%
Molecular Weight	370.4	Type of Compound	Lignans
Formula	C₂₀H₁₈O₇	Physical Description	Powder
Download	COA MSDS SDF Manual	Similar structural	Comparison (Web) (SDF)

Product Name	Paulownin
CAS No.:	13040-46-5
Catalog No.:	CFN99394
Molecular Formula:	C₂₀H₁₈O₇
Molecular Weight:	370.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Targets:	Antifection
Source:	The barks of Paulownia tomentosa
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$188 / 20mg
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Anti-inflammatory Compound Library Antibacterial Compound Library Analgesia Compound Library Antihyperglycemic Compound Library Immunomodulators Compound Library Lignans Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6998 mL	13.4989 mL	26.9978 mL	53.9957 mL	67.4946 mL
5 mM	0.54 mL	2.6998 mL	5.3996 mL	10.7991 mL	13.4989 mL
10 mM	0.27 mL	1.3499 mL	2.6998 mL	5.3996 mL	6.7495 mL
50 mM	0.054 mL	0.27 mL	0.54 mL	1.0799 mL	1.3499 mL
100 mM	0.027 mL	0.135 mL	0.27 mL	0.54 mL	0.6749 mL

CFN97907	Sesartemin	77394-27-5	430.5	C₂₃H₂₆O₈
CFN96936	Episesartemin A	77449-31-1	430.45	C₂₃H₂₆O₈
CFN96713	1-Hydroxypinoresinol 1-O-glucoside	81495-71-8	536.53	C₂₆H₃₂O₁₂
CFN97460	Fraxiresinol 1-O-glucoside	89199-94-0	566.6	C₂₇H₃₄O₁₃
CFN99668	Prenylpiperitol	157659-20-6	424.5	C₂₅H₂₈O₆
CFN95348	Planispine A	1202761-42-9	440.5	C₂₆H₃₂O₆
CFN97034	Sesamin	607-80-7	354.4	C₂₀H₁₈O₆
CFN99394	Paulownin	13040-46-5	370.4	C₂₀H₁₈O₇
CFN99799	Sesamolin	526-07-8	370.36	C₂₀H₁₈O₇
CFN98641	Medioresinol	40957-99-1	388.4	C₂₁H₂₄O₇