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|Size /Price /Stock
||10 mM * 1 mL in DMSO / $121.7 / In-stock||Other Packaging
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More articles cited ChemFaces products.
Mol Cells.2015, 38(9):765-72J Pharm Biomed Anal.2016, 129:50-59Food Sci Biotechnol....2016...Am J Chin Med.2016, 44(8):1719-1735Braz J Med Biol Res. 2016, 49(7)Evid Based Complement Alternat Me...2017...Molecules.2017, 22(6)PLoS One.2018, 13(4):e0195642
Mol Pharm.2018, 15(8):3285-3296Int J Mol Sci.2018, 19(9):E2528Bioorg Med Chem.2018, 26(14):4201-4208Industrial Crops and Products...2018...Curr Eye Res.2018, 43(1):27-34APMIS.2019, 127(10):688-695Molecules.2019, 24(9):E1719Phytother Res.2019, 33(7):1784-1793
Kor. J. Herbol.2019, 34(2):59-66Plos One.2019, 15(2):e0220084Ann Transl Med.2019, 7(23):731Nutrients2020, 12(2):488Evid-Based Compl Alt2020, 7202519:13Asian J Beauty Cosmetol...2020...J Biotechnol.2020, 318:10-19.
Our products had been exported to the following research institutions and universities, And still growing.
Centrum Menselijke Erfelijkheid (Belgium)Seoul National University of Sc... (Korea)University of South Australia (Australia)Heinrich-Heine-University Düss... (Germany)
Wageningen University (Netherlands)University of Wollongong (Australia)Istanbul University (Turkey)Research Unit Molecular Epigene... (Germany)
Shanghai Institute of Biochemis... (China)Helmholtz Zentrum München (Germany)Cornell University (USA)
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Phytomedicine.2019, 67:153159Chem Biol Interact.2016, 260:168-175J Food Biochem.2019, 43(9):e12970Food Res Int.2020, 133:109130.The Pharmaceutical Society of Japan2018, 138(4):571-579J Sep Sci.2018, 41(11):2488-2497Phytomedicine.2016, 23(4):331-9Molecules.2018, 23(11):E2837Nutrients.2019, 11(6):E1380Saf Health Work.2019, 10(2):196-204
Related Screening Libraries
||Peimisine may have antihypertensive action, it can inhibit angiotensin I converting enzyme activity in a dose-dependent manner(the IC50 value of 526.5 microM). Peimisine can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. It plays a protective role against LPS-induced acute lung injury, and against the experimental hepatic fibrosis formation. |
||NO | SOD | Calcium Channel|
|Chinese Traditional & Herbal Drugs, 2009, 40(4):597-601. |
|Antiasthmatic mechanism of peimisine in Fritillaria monantha.[Reference: WebLink]|
|To approach the antiasthmatic mechanism of Peimisine in Fritillaria monatha. |
METHODS AND RESULTS:
To observe the effect of Peimisine in the different concentration on the tracheal smooth muscle contraction in vitro organ induced by Ach, His, β-receptor, CaCl 2, Pro, in nitricoxide synthase catastaltica. Peimisine (0.046 and 0.092 mmol/L) made the EC 50 induced by Ach increased; The EC 50 of peimsine (0.092 mmol/L) was not changed by His; The EC 50 of Peimisine (0.092 mmol/L) was not significantly different to tracheal smooth muscle contraction induced by CaCl 2; Three dosages of Peimisine had significant inhibition on the release of intracellular calcium induced by CaCl 2 (P < 0.05, 0.01, and 0.001) in a dose-dependent manner. But extracellular calcium influx was not significantly inhibited. Comparing with the L-NAME+dissolvant group, three dosages of Peimisine couldn't restrain the contraction and had no significant difference.
Peimisine could affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma.
|Lishizhen Medicine & Materia Medica Research, 2014, 8(13-14):1842-7. |
|Peimisine attenuates acute lung injury induced by lipopolysaccharide in mice[Reference: WebLink]|
| To determine the protective effect of Peimisine on acute lung injury( ALI) induced by lipopolysaccharide( LPS) and its protective mechanism mice. |
METHODS AND RESULTS:
The mice were randomly allocated into sham,LPS and Peimisine + LPS groups. The ALI mice was induced by LPS after etherization. The Peimisine was injected by belly cavity 30 minutes prior to the LPS challenge,one time/d,3 times totally. The mice were killed 24h after the third Peimisine injection to observe the amount of LDH,MDA in plasma,the lung tissue pathology,the total protein,white blood cell and differential count in the bronchoalveolar lavage fluid( BALF). LDH,MDA amount in plasma,Lung tissue,and BALF showed serious inflammatory changes in the LPS group. Compared with the LPS group,Peimisine attenuates Lung tissue injury,LDH and MDA amount in ALI mice in a dose dependent manner. Peimisine( 0. 12mg) lowered the total protein,total white blood cells,lymphocyte and neutrophilic leukocyte in BALF compared with the LPS group.
Peimisine can play a protective role against LPS-induced acute lung injury.
||The bulbs of Fritillaria cirrhosa
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: firstname.lastname@example.org
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|Chinese Traditional & Herbal Drugs, 2013, 44(11):1455-9. |
|Protection of peimisine on hepatic fibrosis of rats induced by CCl4.[Reference: WebLink]|
|To investigate the protective effect of Peimisine on carbon tetrachloride(CCl4)-induced hepatic fibrosis in rats.|
METHODS AND RESULTS:
The rats were divided into control,model,low-,mid-,and high-dose(2.5,5,and 10 mg/kg) Peimisine groups.Hepatic fibrosis models were induced by ip injection of CCl4 in rats once every 3 d for 8 weeks.The rats in the treatment groups were administered four weeks after the model establishment,once daily until the end of the week 4 after the model establishment.The levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),glutamyl transpeptidasecc(GGT),hyaluronie acid(HA),laminin(LN),type III procollagenc(PC-III),and collegen type IV(IV-C) were assayed,and hepatic tissue contents of hydroxyprolinc(Hyp),superoxide dismutase(SOD),and malondialdehyde(MDA) were determined.The effect of Peimisine on hepatic fibrosis in rats was observed. Compared with the model control group,the hepatic fibrosis of rats in Peimisine groups was improved obviously,the levels of ALT,AST,ALP,and GGT in serum were lowered obviously(P 0.05,0.01),also the serum levels of HA,LN,PC-III,IV-C,and the contents of Hyp and MDA in liver tissue were decreased(P 0.01),while the level of SOD was increased(P 0.01).
Peimisine has the protective effect on the experimental hepatic fibrosis formation.The possible mechanisms are associated with inhibiting fibrogenesis and fibrosis accumulation,and decreasing lipid peroxidation.
|Planta Med. 2003 Jun;69(6):564-5. |
|Angiotensin converting enzyme (ACE) inhibitory alkaloids from Fritillaria ussuriensis.[Pubmed: 12865981 ]|
|Bioassay-guided fractionation of the BuOH-soluble extract of Fritillaria ussuriensis afforded verticinone ( 1), verticine ( 2), and Peimisine ( 3). Purification of these compounds was achieved with the use of various chromatographic methods.
METHODS AND RESULTS:
The structures of the compounds were identified on the basis of MS and NMR data analysis. Compounds 1 - 3 inhibited angiotensin I converting enzyme activity in a dose-dependent manner, displaying 50 % inhibitory concentration values of 165.0 microM, 312.8 microM, 526.5 microM, respectively.
The presence of these active substances may be responsible, at least in part, for the antihypertensive action of the bulbs of Fritillaria ussuriensis.