4,7-Didehydroneophysalin B | CAS:134461-76-0

4,7-Didehydroneophysalin B

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In vitro:

J Sep Sci . 2018 Apr;41(8):1781-1790.

Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry[Pubmed: 29331063]

Physalins are the major steroidal constituent of Physalis plants and display a range of biological activities. For this study, a rapid and sensitive high-performance liquid chromatography with triple quadrupole mass spectrometry method was developed for the simultaneous quantification of six physalins. Specifically, it was for the quantification of physalin A, physalin B, physalin D, physalin G, 4,7-Didehydroneophysalin B, and isophysalin B in rat plasma and rat intestinal bacteria. After a solid-phase extraction, analytes and internal standards (prednisolone) were separated on a Shield reverse-phase C18 column (measuring 3 mm × 150 mm with an internal diameter of 3.5 μm) and determined using multiple reactions in a monitoring mode with a positive-ion electrospray ionization source. The mobile phase was a mixture of 0.1% formic acid in water (A) and acetonitrile (B) and was used at a flow rate of 0.6 mL/min. The intra- and interday precisions were within 15% with accuracies ranging from 86.2 to 114%. The method was validated and successfully applied to pharmacokinetics and stability studies of six physalins in rat plasma and rat intestinal bacteria, respectively. The results showed that physalin B and isophysalin B could not be absorbed by rats, and rat intestinal bacteria could quickly transform physalins.

Phytochemistry Volume 34, Issue 2, September 1993, Pages 529-533

Physalin and neophysalins from Physalis alkekengi var. francheti and their differentiation inducing activity[Reference: WebLink]

A methanol extract of Physalis alkekengi var. francheti showed a potent cell differentiation inducing activity toward mouse myeloid leukemia cell line (M1 cells). From the extract, a new physalin and two new neophysalins, 25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A and 4,7-Didehydroneophysalin B, were isolated along with physalin A, L and isophysalin B. The structures of physalins and neophysalins were determined by means of NMR, UV, IR and mass spectra. Of these compounds, physalin A showed potent cell differentiation inducing activity.

4,7-Didehydroneophysalin B Description

Source:	The herbs of Physalis alkekengi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
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PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Structure Identification:

Phytochem Anal . Jul-Aug 2012;23(4):337-44.

Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry[Pubmed: 21997776]

Introduction: Chinese lantern is the calyx or calyx-with-fruit of the plant Physalis alkekengi .var. franchetii (Solanaceae), and is potential material for the food and pharmaceutical industries. Physalins are the most active and representative secondary metabolites of Chinese lantern. A separation and quantification method based on UPLC-ESI-MS/MS was developed for the quantitative analysis of five active physalins. The transformation products were also detected and identified for the first time. Objective: To establish a LC-MS/MS method to quantify five physalins in Chinese lantern for the purpose of quality control, and to identify the transformation products of 4,7-didehydrophysalin B. Methodology: The separation was carried out on an Acquity UPLC BEH Shield RP C₁₈-column with water and acetonitrile as the mobile phase under gradient conditions. ESI-MS/MS was used as the detector to quantify the five physalins. The transformation products of 4,7-Didehydroneophysalin B were detected by UPLC-PDA-ESI-MS/MS and identified through comparing their HRMS and MS2 ion fragmentations with corresponding references. Results: All the compounds showed good linearity (R2 > 0.998). The recoveries, measured at three concentration levels, varied from 98.8 to 101.4% with RSDs < 4.5%. The total contents of the five physalins in Chinese lantern varied significantly. Three transformation products of 4,7-Didehydroneophysalin B were detected and tentatively identified. Conclusion: The present study developed a highly effective analytical method for the quality control of Chinese lantern, and it could provide comprehensive information for quality evaluation and new drug development of Chinese lantern.

CAS No.	134461-76-0	Price	$338 / 5mg
Catalog No.	CFN95317	Purity	>=98%
Molecular Weight	508.5	Type of Compound	Steroids
Formula	C₂₈H₂₈O₉	Physical Description	Powder
Download	COA MSDS	Similar structural	Comparison (Web) (SDF)

Product Name	4,7-Didehydroneophysalin B
CAS No.:	134461-76-0
Catalog No.:	CFN95317
Molecular Formula:	C₂₈H₂₈O₉
Molecular Weight:	508.5 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Physalis alkekengi
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price:	$338 / 5mg
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9666 mL	9.8328 mL	19.6657 mL	39.3314 mL	49.1642 mL
5 mM	0.3933 mL	1.9666 mL	3.9331 mL	7.8663 mL	9.8328 mL
10 mM	0.1967 mL	0.9833 mL	1.9666 mL	3.9331 mL	4.9164 mL
50 mM	0.0393 mL	0.1967 mL	0.3933 mL	0.7866 mL	0.9833 mL
100 mM	0.0197 mL	0.0983 mL	0.1967 mL	0.3933 mL	0.4916 mL

CFN95328	Isophysalin G	152221-21-1	526.5	C₂₈H₃₀O₁₀
CFN92937	Physalin H	70241-09-7	562.99	C₂₈H₃₁ClO₁₀
CFN95317	4,7-Didehydroneophysalin B	134461-76-0	508.5	C₂₈H₂₈O₉
CFN95329	Physalin X	72497-31-5	526.5	C₂₈H₃₀O₁₀
CFN90596	Taccalonolide A	108885-68-3	702.74	C₃₆H₄₆O₁₄
CFN90935	Taccalonolide AJ	1349904-82-0	676.7	C₃₄H₄₄O₁₄
CFN90166	Physalin L	113146-74-0	528.55	C₂₈H₃₂O₁₀
CFN92940	Physalin A	23027-91-0	526.5	C₂₈H₃₀O₁₀
CFN95097	Physalin O	120849-18-5	528.55	C₂₈H₃₂O₁₀
CFN92936	Isophysalin A	1363398-67-7	526.5	C₂₈H₃₀O₁₀