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    Natural Products
    4,7-Didehydroneophysalin B
    4,7-Didehydroneophysalin B
    Information
    CAS No. 134461-76-0 Price $338 / 5mg
    Catalog No.CFN95317Purity>=98%
    Molecular Weight508.5Type of CompoundSteroids
    FormulaC28H28O9Physical DescriptionPowder
    Download     COA    MSDSSimilar structuralComparison (Web)  (SDF)
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    According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
    Size /Price /Stock 10 mM * 1 mL in DMSO / $388.7 / In-stock
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    4,7-Didehydroneophysalin B

    4,7-Didehydroneophysalin B
    Product Name 4,7-Didehydroneophysalin B
    CAS No.: 134461-76-0
    Catalog No.: CFN95317
    Molecular Formula: C28H28O9
    Molecular Weight: 508.5 g/mol
    Purity: >=98%
    Type of Compound: Steroids
    Physical Desc.: Powder
    Source: The herbs of Physalis alkekengi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Price: $338 / 5mg
    Inquire / Order: manager@chemfaces.com
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  • Oxid Med Cell Longev.2021, 2021:4883398.
  • Chinese Medicine2019, 14(1)
  • Sci Rep.2018, 8(1):12970
  • Internoational J of Toxicology2020, 10.1177.
  • Phytomedicine.2019, 59:152785
  • Heliyon2020, 6(6):e04337.
  • Appl. Sci.2020, 10(4),1304
  • Evid Based Complement Alternat Med.2021, 2021:8850744.
  • Front Pharmacol.2021, 12:607403.
  • Sci. Rep.2015, 14-23
  • Related Screening Libraries
    Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
    10 mM * 1 mL in DMSO / Inquiry / In-stock
    Related Libraries
  • Steroids Compound Library
  • Biological Activity
    In vitro:
    J Sep Sci . 2018 Apr;41(8):1781-1790.
    Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry[Pubmed: 29331063]
    Physalins are the major steroidal constituent of Physalis plants and display a range of biological activities. For this study, a rapid and sensitive high-performance liquid chromatography with triple quadrupole mass spectrometry method was developed for the simultaneous quantification of six physalins. Specifically, it was for the quantification of physalin A, physalin B, physalin D, physalin G, 4,7-Didehydroneophysalin B, and isophysalin B in rat plasma and rat intestinal bacteria. After a solid-phase extraction, analytes and internal standards (prednisolone) were separated on a Shield reverse-phase C18 column (measuring 3 mm × 150 mm with an internal diameter of 3.5 μm) and determined using multiple reactions in a monitoring mode with a positive-ion electrospray ionization source. The mobile phase was a mixture of 0.1% formic acid in water (A) and acetonitrile (B) and was used at a flow rate of 0.6 mL/min. The intra- and interday precisions were within 15% with accuracies ranging from 86.2 to 114%. The method was validated and successfully applied to pharmacokinetics and stability studies of six physalins in rat plasma and rat intestinal bacteria, respectively. The results showed that physalin B and isophysalin B could not be absorbed by rats, and rat intestinal bacteria could quickly transform physalins.
    Phytochemistry Volume 34, Issue 2, September 1993, Pages 529-533
    Physalin and neophysalins from Physalis alkekengi var. francheti and their differentiation inducing activity[Reference: WebLink]
    A methanol extract of Physalis alkekengi var. francheti showed a potent cell differentiation inducing activity toward mouse myeloid leukemia cell line (M1 cells). From the extract, a new physalin and two new neophysalins, 25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A and 4,7-Didehydroneophysalin B, were isolated along with physalin A, L and isophysalin B. The structures of physalins and neophysalins were determined by means of NMR, UV, IR and mass spectra. Of these compounds, physalin A showed potent cell differentiation inducing activity.
    4,7-Didehydroneophysalin B Description
    Source: The herbs of Physalis alkekengi
    Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
    Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

    After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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    Calculate Dilution Ratios(Only for Reference)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.9666 mL 9.8328 mL 19.6657 mL 39.3314 mL 49.1642 mL
    5 mM 0.3933 mL 1.9666 mL 3.9331 mL 7.8663 mL 9.8328 mL
    10 mM 0.1967 mL 0.9833 mL 1.9666 mL 3.9331 mL 4.9164 mL
    50 mM 0.0393 mL 0.1967 mL 0.3933 mL 0.7866 mL 0.9833 mL
    100 mM 0.0197 mL 0.0983 mL 0.1967 mL 0.3933 mL 0.4916 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    Protocol
    Structure Identification:
    Phytochem Anal . Jul-Aug 2012;23(4):337-44.
    Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry[Pubmed: 21997776]
    Introduction: Chinese lantern is the calyx or calyx-with-fruit of the plant Physalis alkekengi .var. franchetii (Solanaceae), and is potential material for the food and pharmaceutical industries. Physalins are the most active and representative secondary metabolites of Chinese lantern. A separation and quantification method based on UPLC-ESI-MS/MS was developed for the quantitative analysis of five active physalins. The transformation products were also detected and identified for the first time. Objective: To establish a LC-MS/MS method to quantify five physalins in Chinese lantern for the purpose of quality control, and to identify the transformation products of 4,7-didehydrophysalin B. Methodology: The separation was carried out on an Acquity UPLC BEH Shield RP C₁₈-column with water and acetonitrile as the mobile phase under gradient conditions. ESI-MS/MS was used as the detector to quantify the five physalins. The transformation products of 4,7-Didehydroneophysalin B were detected by UPLC-PDA-ESI-MS/MS and identified through comparing their HRMS and MS2 ion fragmentations with corresponding references. Results: All the compounds showed good linearity (R2 > 0.998). The recoveries, measured at three concentration levels, varied from 98.8 to 101.4% with RSDs < 4.5%. The total contents of the five physalins in Chinese lantern varied significantly. Three transformation products of 4,7-Didehydroneophysalin B were detected and tentatively identified. Conclusion: The present study developed a highly effective analytical method for the quality control of Chinese lantern, and it could provide comprehensive information for quality evaluation and new drug development of Chinese lantern.
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