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1. Reference standards
2. Pharmacological research
3. Inhibitors
4,7-Didehydroneophysalin B
Citing Use of our Products
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* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
| Size /Price /Stock |
10 mM * 1 mL in DMSO / $388.7 / In-stock |
Other Packaging |
*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap |
More articles cited ChemFaces products.
Phytochemistry2018, 15:83-92Sci Adv.2018, 4(10)Molecules.2019, 24(17):E3127Tissue Cell.2022, 75:101728.RSC Advances2017, 86Molecules.2019, 24(2):E343Korean Herb. Med. Inf....2020...Biochem Pharmacol. 2020, 177:114014.
Appl. Sci.2021, 11(1),14.J Mol Recognit.2020, 33(2):e2819Molecules.2020, 25(9):2081.Drug Des Devel Ther.2020, 14:61-71Nutrients.2021, 13(1):254. Phytomedicine.2019, 61:152813Anal Biochem.2019, 569:10-15Rev. Chim.2020, 71(3),558-564
Free Radic Biol Med.2021, 166:104-115.Molecules.2022, 27(2):451.Appl. Sci.2020, 10,1304BioResources J.2020, 15(3).Eur J Pharmacol.2021, 906:174220.Processes2021, 9(11),2065.Korean J of Food Science&Technolo...2017...
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Our products had been exported to the following research institutions and universities, And still growing.
Helmholtz Zentrum München (Germany)Leibniz-Institut für Pflanzenb... (Germany)Leibniz Institute of Plant Bioc... (Germany)Chang Gung University (Taiwan)
Max Rubner-Institut (MRI) (Germany)Sri Ramachandra University (India)Kyushu University (Japan)Institute of Pathophysiology Me... (Austria)
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4,7-Didehydroneophysalin B
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Oxid Med Cell Longev.2021, 2021:4883398.Chinese Medicine2019, 14(1)Sci Rep.2018, 8(1):12970Internoational J of Toxicology2020, 10.1177.Phytomedicine.2019, 59:152785Heliyon2020, 6(6):e04337.Appl. Sci.2020, 10(4),1304Evid Based Complement Alternat Med.2021, 2021:8850744.Front Pharmacol.2021, 12:607403.Sci. Rep.2015, 14-23
Related Screening Libraries
| Size /Price /Stock |
10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
|
Related Libraries |
Steroids Compound Library |
| In vitro: |
| J Sep Sci . 2018 Apr;41(8):1781-1790. | | Simultaneous pharmacokinetics and stability studies of physalins in rat plasma and intestinal bacteria culture media using liquid chromatography with mass spectrometry[Pubmed: 29331063] | | Physalins are the major steroidal constituent of Physalis plants and display a range of biological activities. For this study, a rapid and sensitive high-performance liquid chromatography with triple quadrupole mass spectrometry method was developed for the simultaneous quantification of six physalins. Specifically, it was for the quantification of physalin A, physalin B, physalin D, physalin G, 4,7-Didehydroneophysalin B, and isophysalin B in rat plasma and rat intestinal bacteria. After a solid-phase extraction, analytes and internal standards (prednisolone) were separated on a Shield reverse-phase C18 column (measuring 3 mm × 150 mm with an internal diameter of 3.5 μm) and determined using multiple reactions in a monitoring mode with a positive-ion electrospray ionization source. The mobile phase was a mixture of 0.1% formic acid in water (A) and acetonitrile (B) and was used at a flow rate of 0.6 mL/min. The intra- and interday precisions were within 15% with accuracies ranging from 86.2 to 114%. The method was validated and successfully applied to pharmacokinetics and stability studies of six physalins in rat plasma and rat intestinal bacteria, respectively. The results showed that physalin B and isophysalin B could not be absorbed by rats, and rat intestinal bacteria could quickly transform physalins. | | Phytochemistry Volume 34, Issue 2, September 1993, Pages 529-533 | | Physalin and neophysalins from Physalis alkekengi var. francheti and their differentiation inducing activity[Reference: WebLink] | | A methanol extract of Physalis alkekengi var. francheti showed a potent cell differentiation inducing activity toward mouse myeloid leukemia cell line (M1 cells). From the extract, a new physalin and two new neophysalins, 25,27-dihydro-4,7-didehydro-7-deoxyneophysalin A and 4,7-Didehydroneophysalin B, were isolated along with physalin A, L and isophysalin B. The structures of physalins and neophysalins were determined by means of NMR, UV, IR and mass spectra. Of these compounds, physalin A showed potent cell differentiation inducing activity. |
|
4,7-Didehydroneophysalin B Description
| Source: |
The herbs of Physalis alkekengi |
| Solvent: |
Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc. |
| Storage: |
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
|
| After receiving: |
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling. |
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
1.9666 mL |
9.8328 mL |
19.6657 mL |
39.3314 mL |
49.1642 mL |
| 5 mM |
0.3933 mL |
1.9666 mL |
3.9331 mL |
7.8663 mL |
9.8328 mL |
| 10 mM |
0.1967 mL |
0.9833 mL |
1.9666 mL |
3.9331 mL |
4.9164 mL |
| 50 mM |
0.0393 mL |
0.1967 mL |
0.3933 mL |
0.7866 mL |
0.9833 mL |
| 100 mM |
0.0197 mL |
0.0983 mL |
0.1967 mL |
0.3933 mL |
0.4916 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
| Structure Identification: |
| Phytochem Anal . Jul-Aug 2012;23(4):337-44. | | Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry[Pubmed: 21997776] | | Introduction: Chinese lantern is the calyx or calyx-with-fruit of the plant Physalis alkekengi .var. franchetii (Solanaceae), and is potential material for the food and pharmaceutical industries. Physalins are the most active and representative secondary metabolites of Chinese lantern. A separation and quantification method based on UPLC-ESI-MS/MS was developed for the quantitative analysis of five active physalins. The transformation products were also detected and identified for the first time.
Objective: To establish a LC-MS/MS method to quantify five physalins in Chinese lantern for the purpose of quality control, and to identify the transformation products of 4,7-didehydrophysalin B.
Methodology: The separation was carried out on an Acquity UPLC BEH Shield RP C₁₈-column with water and acetonitrile as the mobile phase under gradient conditions. ESI-MS/MS was used as the detector to quantify the five physalins. The transformation products of 4,7-Didehydroneophysalin B were detected by UPLC-PDA-ESI-MS/MS and identified through comparing their HRMS and MS2 ion fragmentations with corresponding references.
Results: All the compounds showed good linearity (R2 > 0.998). The recoveries, measured at three concentration levels, varied from 98.8 to 101.4% with RSDs < 4.5%. The total contents of the five physalins in Chinese lantern varied significantly. Three transformation products of 4,7-Didehydroneophysalin B were detected and tentatively identified.
Conclusion: The present study developed a highly effective analytical method for the quality control of Chinese lantern, and it could provide comprehensive information for quality evaluation and new drug development of Chinese lantern. |
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