Phellamurin | CAS:52589-11-4 | Manufacturer ChemFaces

Phellamurin

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

Targets:

P-gp

In vivo:

Planta Med. 2002 Feb;68(2):138-41.

Marked decrease of cyclosporin absorption caused by phellamurin in rats.[Pubmed: 11859464]

Phellamurin is a flavonoid glycoside that is abundant in the leaves of Phellodendron wilsonii Hayata et Kanehira (Rutaceae). In vitro everted rat intestine study indicated that Phellamurin inhibited intestinal P-glycoprotein in a dose-dependent manner.
METHODS AND RESULTS:
In order to investigate the effect of Phellamurin on cyclosporin absorption and disposition, rats were given cyclosporin (5 mg/kg) with or without Phellamurin in a parallel design. Fluorescence polarization immunoassay was used to determine the blood concentration of cyclosporin. Unanticipatedly, our results indicated that the coadministration of Phellamurin significantly decreased the Cmax of cyclosporin by 77 % and reduced the AUC(0-infinity) of cyclosporin by 56 %.
CONCLUSIONS:
This indicated that a serious interaction occurred between Phellamurin with cyclosporin. To ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.

Phellamurin Description

Source:	The barks of Phellodendron chinense Schneid.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Phellamurin
Price:
CAS No.:	52589-11-4
Catalog No.:	CFN98863
Molecular Formula:	C₂₆H₃₀O₁₁
Molecular Weight:	518.5 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The barks of Phellodendron chinense Schneid.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Flavonoids Compound Library P-gp Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9286 mL	9.6432 mL	19.2864 mL	38.5728 mL	48.216 mL
5 mM	0.3857 mL	1.9286 mL	3.8573 mL	7.7146 mL	9.6432 mL
10 mM	0.1929 mL	0.9643 mL	1.9286 mL	3.8573 mL	4.8216 mL
50 mM	0.0386 mL	0.1929 mL	0.3857 mL	0.7715 mL	0.9643 mL
100 mM	0.0193 mL	0.0964 mL	0.1929 mL	0.3857 mL	0.4822 mL

CFN99389	(2S,3S)-(-)-Glucodistylin	129212-92-6	466.4	C₂₁H₂₂O₁₂
CFN96494	Taxifolin 3'-O-glucoside	31106-05-5	342.29	C₂₁H₂₂O₁₂
CFN96539	Taxifolin 7-O-rhamnoside	137592-12-2	450.40	C₂₁H₂₂O₁₁
CFN91506	Taxifolin 7-O-glucoside	14292-40-1	466.4	C₂₁H₂₂O₁₂
CFN95018	7-Neohesperidosides	28383-41-7	626.6	C₂₈H₃₄O₁₆
CFN95284	Isoengeletin	30987-58-7	434.4	C₂₁H₂₂O₁₀
CFN89542	Aromadendrin 7-O-rhamnoside	69135-41-7	434.39	C₂₁H₂₂O₁₀
CFN97925	Sinensin	28189-90-4	450.4	C₂₁H₂₂O₁₁
CFN98863	Phellamurin	52589-11-4	518.5	C₂₆H₃₀O₁₁
CFN98637	Taxifolin 3-O-beta-D-xylopyranoside	40672-47-7	436.4	C₂₀H₂₀O₁₁