ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
How to Order
Orders via your E-mail:
1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Sent to Email: firstname.lastname@example.org
Order & Inquiry & Tech Support
Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
Delivery & Payment method
1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / Inquiry||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
Int J Mol Sci.2015, 16(8):18396-411Chem Biol Interact.2016, 258:59-68J Chromatogr B Analyt Technol Bio...2017...Journal of Functional Foods...2017...Korean J of Food Science&Technolo...2017...BMC Complement Altern Med....2018...Molecules.2018, 23(12):E3103Pak J Pharm Sci.2018, 31:311-315
Korean Journal of Pharmacognosy...2018...J Nat Med.2018, 72(3):734-744Drug Invention Today...2019...Evid Based Complement Alternat Me...2019...Molecules.2019, 24(19):E3417The Korea Journal of Herbology...2019...Cell Physiol Biochem....2019...Sci Rep.2019, 9(1):4646
Food Analytical Methods2020, 1-10J Pharmaceut Biomed2020, 182:113110Biochem Biophys Res Commun....2020...Biomolecules.2020, 10(6):925.Front Pharmacol.2020, 11:251.Institut Pasteur Korea...2020...Front Plant Sci.2020，11:630.
Our products had been exported to the following research institutions and universities, And still growing.
FORTH-IMBB (Greece)Cancer Research Initatives Foun... (Malaysia)Kyoto University (Japan)Uniwersytet Jagielloński w Kra... (Poland)
Institute of Chinese Materia Me... (China)Colorado State University (USA)Medizinische Universit?t Wien (Austria)Wroclaw Medical University (Poland)
University of Perugia (Italy)S.N.D.T. Women's University (India)University of Toulouse (France)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Oncotarget.2017, 8(53):90925-90947J Separation Science & Technology2016, 51:1579-1588J Agric Food Chem.2017, 65(13):2670-2676Appl. Sci.2020, 10(8),2804Naunyn Schmiedebergs Arch Pharmacol.2017, 390(10):1073-1083Drug Des Devel Ther.2020, 14:5189-5204.New Journal of Chemistry2019, 43:12538-12547 Int J Mol Sci.2020, 21(24):9369.Oncology Letters2018, 4690-4696Int J Med Sci.2020, 17(5):626-631
Related Screening Libraries
|| Picrinine has notable antitussive, antiasthmatic, expectorant, antiinflammatory and analgesic effects; medicinal composition containing picrinine as active ingredient can be prepared into multiple dosage forms and can be used for treating cold, fever, and respiratory disease caused by fever with good therapeutic effect, convenient application and high safety; picrinine can be used as quality index for pharmic control in preparing medicine for treating cold, fever and respiratory disease caused by fever.|
||The roots of Rauvolfia verticillata.
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
|J Org Chem. 2015 Jul 13. |
|Fischer Indolizations as a Strategic Platform for the Total Synthesis of Picrinine.[Pubmed: 26134260]|
|Picrinine, which is a member of the akuammiline family of alkaloids, was first isolated in 1965 from the leaves of Alstonia scholaris. The natural product possesses a daunting polycyclic skeleton that contains a furanoindoline, a bridged [3.3.1]azabicycle, two N,O-acetal linkages, and six stereogenic centers. These structural features render Picrinine a challenging and attractive target for total synthesis.
METHODS AND RESULTS:
This paper provides a full account of our synthetic forays toward Picrinine, which culminates in the first total synthesis of this long-standing target. Central to the success of our approach is the use of the Fischer indolization reaction to introduce the C7 quaternary stereocenter and the indoline nucleus of the natural product's scaffold. We probe some of the subtleties of this classic transformation by examining some of the most complex Fischer indolization substrates to date. Additionally, we describe various roadblocks encountered in our experimental efforts, which were successfully overcome to complete the total synthesis of Picrinine.
Picrinine References Information
J Am Chem Soc. 2014 Mar 26;136(12):4504-7.
|Total synthesis of the akuammiline alkaloid picrinine.[Pubmed: 24597784 ]|
|We report the first total synthesis of the complex akuammiline alkaloid Picrinine, which was first isolated nearly five decades ago. Our synthetic approach features a concise assembly of the [3.3.1]-azabicyclic core, a key Fischer indolization reaction to forge the natural product's carbon framework, and a series of delicate late-stage transformations to complete the synthesis. Our synthesis of Picrinine also constitutes a formal synthesis of the related polycyclic alkaloid strictamine.
CN 101084894 B[P]. 2011.
|Medicine for treating diseases concerned with respiratory and use thereof[Reference: WebLink]|
|The invention discloses Picrinine (indoles) isolated from Alstonia scholaris. Picrinine has notable antitussive, antiasthmatic, expectorant, antiinflammatory and analgesic effects. Medicinal composition containing Picrinine as active ingredient can be prepared into multiple dosage forms and can be used for treating cold, fever, and respiratory disease caused by fever with good therapeutic effect, convenient application and high safety. Picrinine can be used as quality index for pharmic control in preparing medicine for treating cold, fever and respiratory disease caused by fever.