ChemFaces is a professional high-purity natural products manufacturer.
Product Intended Use
1. Reference standards
2. Pharmacological research
Citing Use of our Products
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Address: No. 83, CheCheng Rd., WETDZ, Wuhan, Hubei 430056, PRC
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1. Usually delivery time: Next day delivery by 9:00 a.m. Order now
2. We accept: Wire transfer & Credit card & Paypal & Western Union
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
|Size /Price /Stock
||10 mM * 1 mL in DMSO / $49.6 / In-stock||Other Packaging
||*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
More articles cited ChemFaces products.
J Nat Prod.2015, 78(6):1339-4Evid Based Complement Alternat Me...2016...Biomed Chromatogr.2016, 30(10):1573-81J Ethnopharmacol.2017, 198:91-97J Biochem Mol Toxicol.2017, 31(9)J Hematol Oncol.2018, 11(1):112Mol Pharm.2018, 15(8):3285-3296Integr Cancer Ther.2018, 17(3):832-843
Korean Journal of Medicinal Crop ...2018...Oncology Letters2018, 4690-4696Biochem Biophys Res Commun....2018...Biochem Biophys Res Commun....2018...Primary and Industrial.2018, 52(11)Planta Med.2018, 84(15):1101-1109Front Immunol.2018, 9:2655Pharmacognosy Journal...2019...
Molecules.2019, 24(4):E744J of Dentistry & Oral Health...2019...Int J Mol Med.2019, 43(6):2516-2522Food Chem Toxicol.2020, 135:110863Int J Mol Sci.2020, 21(6):2190. Bioorg Med Chem.2020, 28(12):115553.Natural Product Communications...2020...
Our products had been exported to the following research institutions and universities, And still growing.
University of Indonesia (Indonesia)Universidad Miguel Hernández (Spain)Molecular Biology Institute of ... (Spain)Julius Kühn-Institut (Germany)
Chinese University of Hong Kong (China)University of Oslo (Norway)Mendel University in Brno (Czech Republic)University of Queensland (Australia)
Agricultural Research Organizat... (Israel)University of Maryland (USA)Kitasato University (Japan)
Inquire / Order:
1 Building, No. 83, CheCheng Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC
Int J Mol Sci.2019, 21(1):E265J Cancer.2019, 10(23):5843-5851Arch Pharm Res.2015, 38(6):1080-9J of the Korean Society of Cosmetics and Cosmetology2018, 399-406Food Funct.2020, 11(2):1322-1333.BMC Complement Altern Med.2014, 14:242Nutrients.2019, 12(1)BMC Pharmacol Toxicol.2018, 19(1):5Postharvest Biol Tec2019, 149:18-26Molecules.2020 ,25(16):3697.
Related Screening Libraries
||Hydroxygenkwanin has cytotoxicity, may be an effective natural product to treat glioma, and the combination of Apigenin and Hydroxygenkwanin may be a promising method for glioma chemotherapy.|
||TNF-α | Caspase | BID | BAK | BCL-XL|
|Chem Biol Interact. 2013 Nov 25;206(2):346-55. |
|Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.[Pubmed: 24144774]|
|Apigenin (AP) and Hydroxygenkwanin (HGK) are two natural flavonoid compounds. Previous studies have already demonstrated the anti-tumor capability of AP. However, it is not clear whether Hydroxygenkwanin has such property.|
METHODS AND RESULTS:
In the current study, the anti-glioma activities of Hydroxygenkwanin and its synergistic anti-glioma effects with AP on C6 glioma cells were investigated. In addition, the possible mechanisms were also studied. MTT assay and morphologic analysis including acridine orange/ethidium bromide (AO/EB) and 4',6-diamidino-2-phenylindole (DAPI) staining were used in the research, and the results indicated that the treatment with AP or Hydroxygenkwanin could inhibit C6 glioma cell proliferation respectively. Moreover, when AP was administrated simultaneously, the anti-glioma effect of Hydroxygenkwanin was dramatically enhanced in a dose-dependent manner, which is obviously better than that of carmustine (BCNU) at the concentration 25μM for treating of 24h. Compared with control, mitochondrial membrane potential (MPP) loss and mitochondrion damage were detected by JC-1 fluorescence probes (JC-1) and transmission electron microscopy (TEM) after treatment. Obvious DNA damage and cell cycle S phase arrest were detected by alkaline comet assay and flow cytometric analysis (FCM). Additionally, up regulation of TNF-α level, activations of caspase-3, -8, over expressions of BID and BAK protein and BCL-XL protein down expression were also observed after treatment by the combination of AP and Hydroxygenkwanin .
The results indicate that Hydroxygenkwanin may be an effective natural product to treat glioma, and the combination of AP and Hydroxygenkwanin may be a promising method for glioma chemotherapy.
||The herbs of Lobelia chinensis
||Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
||Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please email to: email@example.com
||The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.IF=12.804(2019)PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.